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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KIF3B

Summary for KIF3B

Gene information	Gene symbol	KIF3B
	Ensembl ID	ENSG00000101350
	Entrez ID	9371
	Gene name	kinesin family member 3B
	Synonyms	FLA8\|KIAA0359\|KLP-11
	Gene type	protein_coding
	UniProtAcc	O15066

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Dataset with differentially expressed gene: KIF3B

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.755059	1.18e-03
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.405424	5.49e-27

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Expression of KIF3B in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KIF3B

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KIF3B

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KIF3B	hsa-miR-605-3p	98.8948	NM_004798
KIF3B	hsa-miR-6770-5p	97.5427	NM_004798
KIF3B	hsa-miR-4262	96.9928	NM_004798
KIF3B	hsa-miR-1225-3p	94.7438	NM_004798
KIF3B	hsa-miR-3119	94.5596	NM_004798
KIF3B	hsa-miR-135a-5p	94.5299	NM_004798
KIF3B	hsa-miR-135b-5p	94.5299	NM_004798
KIF3B	hsa-miR-18a-3p	93.7249	NM_004798
KIF3B	hsa-miR-20a-5p	93.5523	NM_004798
KIF3B	hsa-miR-106b-5p	93.5523	NM_004798
KIF3B	hsa-miR-106a-5p	93.4516	NM_004798
KIF3B	hsa-miR-6811-5p	93.4198	NM_004798
KIF3B	hsa-miR-6511b-5p	93.4198	NM_004798
KIF3B	hsa-miR-17-5p	93.287	NM_004798
KIF3B	hsa-miR-20b-5p	93.287	NM_004798
KIF3B	hsa-miR-93-5p	93.287	NM_004798
KIF3B	hsa-miR-519d-3p	93.287	NM_004798
KIF3B	hsa-miR-942-5p	93.1046	NM_004798
KIF3B	hsa-miR-181b-5p	92.8955	NM_004798
KIF3B	hsa-miR-181d-5p	92.8955	NM_004798
KIF3B	hsa-miR-181a-5p	92.8955	NM_004798
KIF3B	hsa-miR-181c-5p	92.8955	NM_004798
KIF3B	hsa-miR-302e	91.5469	NM_004798
KIF3B	hsa-miR-526b-3p	91.482	NM_004798
KIF3B	hsa-miR-4323	90.7794	NM_004798
KIF3B	hsa-miR-5582-3p	90.6793	NM_004798
KIF3B	hsa-miR-466	89.8068	NM_004798
KIF3B	hsa-miR-6088	89.6874	NM_004798
KIF3B	hsa-miR-127-3p	89.4582	NM_004798
KIF3B	hsa-miR-1913	88.6839	NM_004798
KIF3B	hsa-miR-4708-5p	88.5824	NM_004798
KIF3B	hsa-miR-143-3p	88.5223	NM_004798
KIF3B	hsa-miR-4770	88.5223	NM_004798
KIF3B	hsa-miR-1909-5p	88.2555	NM_004798
KIF3B	hsa-miR-646	87.6038	NM_004798
KIF3B	hsa-miR-520d-3p	86.8121	NM_004798
KIF3B	hsa-miR-372-3p	86.8121	NM_004798
KIF3B	hsa-miR-302d-3p	86.8121	NM_004798
KIF3B	hsa-miR-520e-3p	86.8121	NM_004798
KIF3B	hsa-miR-302b-3p	86.8121	NM_004798
KIF3B	hsa-miR-373-3p	86.8121	NM_004798
KIF3B	hsa-miR-302c-3p	86.8121	NM_004798
KIF3B	hsa-miR-302a-3p	86.8121	NM_004798
KIF3B	hsa-miR-520c-3p	86.8121	NM_004798
KIF3B	hsa-miR-520a-3p	86.8121	NM_004798
KIF3B	hsa-miR-520b-3p	86.8121	NM_004798
KIF3B	hsa-miR-3974	86.8038	NM_004798
KIF3B	hsa-miR-8077	86.7609	NM_004798
KIF3B	hsa-miR-6760-3p	86.5717	NM_004798
KIF3B	hsa-miR-6838-5p	85.8731	NM_004798

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Motifs and transcription factors (TFs) regulating KIF3B

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."