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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: KIAA1671

Summary for KIAA1671

Gene informationGene symbol

KIAA1671

Ensembl ID

ENSG00000197077

Entrez ID

85379

Gene nameKIAA1671
SynonymsNA
Gene typeprotein_coding
UniProtAcc

Q9BY89


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Dataset with differentially expressed gene: KIAA1671

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postFibroblasts-0.4854274.16e-02

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.260969.61e-16

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells-0.3706460.00e+00

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Expression of KIAA1671 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to KIAA1671

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KIAA1671

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
KIAA1671hsa-miR-6867-5p98.6403NM_001145206
KIAA1671hsa-miR-391095.8621NM_001145206
KIAA1671hsa-miR-514a-5p93.6252NM_001145206
KIAA1671hsa-miR-444193.3348NM_001145206
KIAA1671hsa-miR-548e-5p92.6659NM_001145206
KIAA1671hsa-miR-5011-5p92.5601NM_001145206
KIAA1671hsa-miR-137-3p91.6786NM_001145206
KIAA1671hsa-miR-493-5p90.5225NM_001145206
KIAA1671hsa-miR-651-5p88.9273NM_001145206
KIAA1671hsa-miR-427088.8822NM_001145206
KIAA1671hsa-miR-6511b-3p87.5461NM_001145206
KIAA1671hsa-miR-6511a-3p87.5461NM_001145206
KIAA1671hsa-miR-141-5p87.2095NM_001145206
KIAA1671hsa-miR-4712-3p86.9884NM_001145206
KIAA1671hsa-miR-449186.3008NM_001145206
KIAA1671hsa-miR-465786.3008NM_001145206
KIAA1671hsa-miR-124-3p85.8976NM_001145206
KIAA1671hsa-miR-506-3p85.8976NM_001145206
KIAA1671hsa-miR-76585.3132NM_001145206
KIAA1671hsa-miR-128385.1617NM_001145206
KIAA1671hsa-miR-7854-3p84.8639NM_001145206
KIAA1671hsa-miR-3691-3p84.7312NM_001145206
KIAA1671hsa-miR-1252-5p84.1754NM_001145206
KIAA1671hsa-miR-1212884.1406NM_001145206
KIAA1671hsa-miR-6754-5p83.5002NM_001145206
KIAA1671hsa-miR-6815-3p82.3691NM_001145206
KIAA1671hsa-miR-582-5p82.1742NM_001145206
KIAA1671hsa-miR-428682.1741NM_001145206
KIAA1671hsa-miR-318281.8486NM_001145206
KIAA1671hsa-miR-11181-3p81.5142NM_001145206
KIAA1671hsa-miR-544b80.3084NM_001145206
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Motifs and transcription factors (TFs) regulating KIAA1671

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
KIAA1671metacluster_74.6HNF1A (directAnnotation).
KIAA1671homer__GTCACGCTCNCTGA_PAX5PAX5 (directAnnotation).
KIAA1671taipale_tf_pairs__ETV7_TBX21_NSCGGAARNNNNNNTCACACNN_CAP_reprETV7; TBX21 (directAnnotation).
KIAA1671transfac_pro__M06600ZNF566 (directAnnotation).
KIAA1671transfac_pro__M01843BHLHE41 (directAnnotation).
KIAA1671metacluster_75.12SCRT1; SCRT2 (directAnnotation).
KIAA1671metacluster_76.1ZNF345; ZNF345 (directAnnotation). MYB; MYBL1 (inferredBy_Orthology).
KIAA1671tfdimers__MD00112DBP; TFAP2C (directAnnotation).
KIAA1671transfac_pro__M03541JUN (directAnnotation).
KIAA1671transfac_pro__M08873DLX2 (directAnnotation).
KIAA1671cisbp__M01272ZZZ3 (directAnnotation).
KIAA1671hocomoco__HMBX1_HUMAN.H11MO.0.DHMBOX1 (directAnnotation).
KIAA1671transfac_pro__M08803CREM (directAnnotation).
KIAA1671transfac_pro__M06149ZNF132 (directAnnotation).
KIAA1671tfdimers__MD00516SOX10 (directAnnotation).
Page: 1

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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."