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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KIAA1586

Summary for KIAA1586

Gene information	Gene symbol	KIAA1586
	Ensembl ID	ENSG00000168116
	Entrez ID	57691
	Gene name	KIAA1586
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KIAA1586

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.289903	5.46e-15
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.340009	0.00e+00

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Expression of KIAA1586 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KIAA1586

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KIAA1586

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KIAA1586	hsa-miR-130a-5p	97.1446	NM_001286276
KIAA1586	hsa-miR-3924	96.5127	NM_001286276
KIAA1586	hsa-miR-5683	90.7377	NM_001286276
KIAA1586	hsa-miR-6809-3p	89.3016	NM_001286276
KIAA1586	hsa-miR-6759-3p	88.6824	NM_001286276
KIAA1586	hsa-miR-559	87.2879	NM_001286276
KIAA1586	hsa-miR-101-3p	85.9606	NM_001286276
KIAA1586	hsa-miR-548aq-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548ar-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548i	84.4369	NM_001286276
KIAA1586	hsa-miR-548ae-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548as-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548bb-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548b-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548c-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548a-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548ab	84.4369	NM_001286276
KIAA1586	hsa-miR-548y	84.4369	NM_001286276
KIAA1586	hsa-miR-548d-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548o-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548ap-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548ak	84.4369	NM_001286276
KIAA1586	hsa-miR-548w	84.4369	NM_001286276
KIAA1586	hsa-miR-548h-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548am-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548au-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548j-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548ay-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-548ad-5p	84.4369	NM_001286276
KIAA1586	hsa-miR-4753-3p	83.4612	NM_001286276
KIAA1586	hsa-miR-424-3p	82.7001	NM_001286276

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Motifs and transcription factors (TFs) regulating KIAA1586

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KIAA1586	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."