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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KIAA1522

Summary for KIAA1522

Gene information	Gene symbol	KIAA1522
	Ensembl ID	ENSG00000162522
	Entrez ID	57648
	Gene name	KIAA1522
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9P206

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Dataset with differentially expressed gene: KIAA1522

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.540853	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.566403	0.00e+00

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Expression of KIAA1522 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KIAA1522

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KIAA1522

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KIAA1522	hsa-miR-5011-5p	99.9642	NM_020888
KIAA1522	hsa-miR-190a-3p	99.4087	NM_020888
KIAA1522	hsa-miR-378b	97.5487	NM_001198973
KIAA1522	hsa-miR-378f	97.0965	NM_001198973
KIAA1522	hsa-miR-378d	97.0965	NM_001198973
KIAA1522	hsa-miR-378a-3p	97.0965	NM_001198973
KIAA1522	hsa-miR-378i	97.0965	NM_001198973
KIAA1522	hsa-miR-422a	97.0965	NM_001198973
KIAA1522	hsa-miR-378h	97.0965	NM_001198973
KIAA1522	hsa-miR-378e	97.0965	NM_001198973
KIAA1522	hsa-miR-378c	97.0965	NM_001198973
KIAA1522	hsa-miR-4319	94.1127	NM_020888
KIAA1522	hsa-miR-302e	94.0231	NM_020888
KIAA1522	hsa-miR-302c-3p	93.7796	NM_020888
KIAA1522	hsa-miR-520b-3p	93.7796	NM_020888
KIAA1522	hsa-miR-302b-3p	93.7796	NM_020888
KIAA1522	hsa-miR-520d-3p	93.7796	NM_020888
KIAA1522	hsa-miR-520a-3p	93.7796	NM_020888
KIAA1522	hsa-miR-520e-3p	93.7796	NM_020888
KIAA1522	hsa-miR-520c-3p	93.7796	NM_020888
KIAA1522	hsa-miR-372-3p	93.7796	NM_020888
KIAA1522	hsa-miR-302a-3p	93.7796	NM_020888
KIAA1522	hsa-miR-302d-3p	93.7796	NM_020888
KIAA1522	hsa-miR-373-3p	93.7756	NM_020888
KIAA1522	hsa-miR-125a-5p	93.3673	NM_020888
KIAA1522	hsa-miR-125b-5p	93.3673	NM_020888
KIAA1522	hsa-miR-6845-3p	91.1132	NM_020888
KIAA1522	hsa-miR-4432	91.0794	NM_001198973
KIAA1522	hsa-miR-520f-3p	89.4511	NM_020888
KIAA1522	hsa-miR-4711-3p	89.2076	NM_020888
KIAA1522	hsa-miR-4327	88.868	NM_020888
KIAA1522	hsa-miR-4753-5p	88.8565	NM_020888
KIAA1522	hsa-miR-3188	87.6815	NM_020888
KIAA1522	hsa-miR-5696	87.6803	NM_001198973
KIAA1522	hsa-miR-3127-5p	87.4181	NM_001198973
KIAA1522	hsa-miR-2113	87.2589	NM_020888
KIAA1522	hsa-miR-3688-3p	87.0885	NM_001198973
KIAA1522	hsa-miR-218-5p	85.5466	NM_020888
KIAA1522	hsa-miR-6847-5p	84.5935	NM_001198973
KIAA1522	hsa-miR-30e-5p	83.029	NM_020888
KIAA1522	hsa-miR-4324	82.6677	NM_020888
KIAA1522	hsa-miR-888-5p	81.3989	NM_001198973
KIAA1522	hsa-miR-3143	81.1648	NM_020888
KIAA1522	hsa-miR-4434	80.5751	NM_001198973
KIAA1522	hsa-miR-4516	80.5751	NM_001198973
KIAA1522	hsa-miR-494-3p	80.3607	NM_020888
KIAA1522	hsa-miR-1251-3p	80.2455	NM_020888

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Motifs and transcription factors (TFs) regulating KIAA1522

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KIAA1522	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
KIAA1522	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
KIAA1522	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
KIAA1522	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
KIAA1522	transfac_pro__M00652	NRF1 (directAnnotation).
KIAA1522	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
KIAA1522	jaspar__MA1122.1	TFDP1 (directAnnotation).
KIAA1522	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KIAA1522	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
KIAA1522	metacluster_151.2	ZNF23 (directAnnotation).
KIAA1522	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."