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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KIAA1217

Summary for KIAA1217

Gene information	Gene symbol	KIAA1217
	Ensembl ID	ENSG00000120549
	Entrez ID	56243
	Gene name	KIAA1217
	Synonyms	DKFZP761L0424\|ETL4\|SKT
	Gene type	protein_coding
	UniProtAcc	Q5T5P2

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Dataset with differentially expressed gene: KIAA1217

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.378255	9.53e-39

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Expression of KIAA1217 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KIAA1217

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KIAA1217

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KIAA1217	hsa-miR-570-3p	99.5624	NM_001321681
KIAA1217	hsa-miR-98-3p	98.1571	NM_019590
KIAA1217	hsa-miR-3686	97.986	NM_019590
KIAA1217	hsa-let-7a-3p	97.501	NM_019590
KIAA1217	hsa-let-7f-1-3p	97.501	NM_019590
KIAA1217	hsa-let-7b-3p	97.501	NM_019590
KIAA1217	hsa-miR-148a-3p	96.2589	NM_019590
KIAA1217	hsa-miR-148b-3p	96.2589	NM_019590
KIAA1217	hsa-miR-152-3p	96.2589	NM_019590
KIAA1217	hsa-miR-182-5p	95.5635	NM_019590
KIAA1217	hsa-miR-651-3p	95.5368	NM_019590
KIAA1217	hsa-miR-4666a-5p	95.4896	NM_019590
KIAA1217	hsa-miR-5002-5p	95.3635	NM_001282769
KIAA1217	hsa-miR-4699-3p	94.4277	NM_019590
KIAA1217	hsa-miR-550b-2-5p	94.0404	NM_001321681
KIAA1217	hsa-miR-449a	94.0274	NM_019590
KIAA1217	hsa-miR-34a-5p	94.0274	NM_019590
KIAA1217	hsa-miR-6728-3p	93.9044	NM_019590
KIAA1217	hsa-miR-9-3p	93.4807	NM_019590
KIAA1217	hsa-miR-449b-5p	93.39	NM_019590
KIAA1217	hsa-miR-34c-5p	93.39	NM_019590
KIAA1217	hsa-miR-6876-5p	93.0074	NM_001321681
KIAA1217	hsa-miR-4476	93.0074	NM_001321681
KIAA1217	hsa-miR-7109-3p	92.9262	NM_019590
KIAA1217	hsa-miR-200b-5p	91.0321	NM_001282769
KIAA1217	hsa-miR-200a-5p	91.0321	NM_001282769
KIAA1217	hsa-miR-3973	90.263	NM_001282769
KIAA1217	hsa-miR-4698	90.0985	NM_001321681
KIAA1217	hsa-miR-3120-3p	89.4736	NM_001321681
KIAA1217	hsa-miR-4422	88.0765	NM_019590
KIAA1217	hsa-miR-12120	87.925	NM_019590
KIAA1217	hsa-miR-4464	87.7278	NM_001321681
KIAA1217	hsa-miR-4748	87.7278	NM_001321681
KIAA1217	hsa-miR-148b-5p	87.6686	NM_001321681
KIAA1217	hsa-miR-6874-3p	87.6686	NM_001321681
KIAA1217	hsa-miR-96-5p	87.5162	NM_019590
KIAA1217	hsa-miR-487a-3p	87.14	NM_001321681
KIAA1217	hsa-miR-154-3p	87.14	NM_001321681
KIAA1217	hsa-miR-4789-5p	86.7237	NM_019590
KIAA1217	hsa-miR-190a-3p	86.5893	NM_019590
KIAA1217	hsa-miR-129-1-3p	86.3013	NM_019590
KIAA1217	hsa-miR-129-2-3p	86.3013	NM_019590
KIAA1217	hsa-miR-585-5p	85.7822	NM_001321681
KIAA1217	hsa-miR-144-3p	85.7159	NM_001321681
KIAA1217	hsa-miR-12133	85.4464	NM_019590
KIAA1217	hsa-miR-1271-5p	85.4464	NM_019590
KIAA1217	hsa-miR-1299	85.113	NM_001321681
KIAA1217	hsa-miR-3914	83.9055	NM_001321681
KIAA1217	hsa-miR-5692a	83.8189	NM_001321681
KIAA1217	hsa-miR-593-3p	83.1446	NM_019590

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Motifs and transcription factors (TFs) regulating KIAA1217

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KIAA1217	metacluster_135.11	NR2C2 (directAnnotation).
KIAA1217	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KIAA1217	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KIAA1217	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KIAA1217	cisbp__M00968	MTF2 (directAnnotation).
KIAA1217	metacluster_160.20	JUND; PRDM15 (directAnnotation).
KIAA1217	cisbp__M00341	PAX6 (directAnnotation).
KIAA1217	metacluster_198.3	ZFP64 (directAnnotation).
KIAA1217	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
KIAA1217	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
KIAA1217	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
KIAA1217	metacluster_175.1	ZNF283 (directAnnotation).
KIAA1217	hdpi__ZNF304	ZNF304 (directAnnotation).
KIAA1217	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
KIAA1217	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
KIAA1217	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
KIAA1217	transfac_pro__M01199	TRIM28 (directAnnotation).
KIAA1217	metacluster_151.2	ZNF23 (directAnnotation).
KIAA1217	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KIAA1217	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KIAA1217	transfac_pro__M03806	ZBTB7C (directAnnotation).
KIAA1217	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."