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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KIAA0040

Summary for KIAA0040

Gene information	Gene symbol	KIAA0040
	Ensembl ID	ENSG00000235750
	Entrez ID	9674
	Gene name	KIAA0040
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q15053

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Dataset with differentially expressed gene: KIAA0040

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	4.32582	1.15e-05
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	B cells	-0.41403	6.29e-03

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Expression of KIAA0040 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KIAA0040

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KIAA0040

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KIAA0040	hsa-miR-6867-5p	99.6147	NM_001162893
KIAA0040	hsa-miR-134-5p	96.9529	NM_001162893
KIAA0040	hsa-miR-3118	96.9529	NM_001162893
KIAA0040	hsa-miR-1263	93.8755	NM_001162893
KIAA0040	hsa-miR-1250-3p	91.5733	NM_001162893
KIAA0040	hsa-miR-8485	90.1804	NM_001162893
KIAA0040	hsa-miR-22-3p	90.1752	NM_001162893
KIAA0040	hsa-miR-6861-3p	87.7466	NM_001162893
KIAA0040	hsa-miR-4481	85.9153	NM_001162893
KIAA0040	hsa-miR-106a-3p	84.7805	NM_001162893
KIAA0040	hsa-miR-5693	84.0946	NM_001162893
KIAA0040	hsa-miR-4668-5p	83.8124	NM_001162893
KIAA0040	hsa-miR-4758-5p	83.5378	NM_001162893
KIAA0040	hsa-miR-1238-5p	83.5378	NM_001162893
KIAA0040	hsa-miR-12122	83.5361	NM_001162893
KIAA0040	hsa-miR-7162-3p	82.9196	NM_001162893
KIAA0040	hsa-miR-599	82.6571	NM_001162893
KIAA0040	hsa-miR-597-5p	82.1535	NM_001162893
KIAA0040	hsa-miR-4652-5p	81.5356	NM_001162893
KIAA0040	hsa-miR-4531	81.4894	NM_001162893
KIAA0040	hsa-miR-12119	81.4456	NM_001162893
KIAA0040	hsa-miR-4745-5p	80.6371	NM_001162893
KIAA0040	hsa-miR-4775	80.5511	NM_001162893

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Motifs and transcription factors (TFs) regulating KIAA0040

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KIAA0040	jaspar__MA1125.1	ZNF384 (directAnnotation).
KIAA0040	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
KIAA0040	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
KIAA0040	transfac_pro__M06272	ZNF569 (directAnnotation).
KIAA0040	tfdimers__MD00032	GFI1; GFI1B; NKX3-2 (directAnnotation).
KIAA0040	cisbp__M01815	CEBPE (inferredBy_Orthology).
KIAA0040	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
KIAA0040	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
KIAA0040	tfdimers__MD00423	ARID3A; PAX4 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."