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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: KHSRP

Summary for KHSRP

Gene information	Gene symbol	KHSRP
	Ensembl ID	ENSG00000088247
	Entrez ID	8570
	Gene name	KH-type splicing regulatory protein
	Synonyms	FBP2\|FUBP2\|KSRP
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KHSRP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.618123	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.296824	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.666875	0.00e+00

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Expression of KHSRP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KHSRP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KHSRP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KHSRP	hsa-miR-5011-5p	99.9079	NM_003685
KHSRP	hsa-miR-190a-3p	97.4065	NM_003685
KHSRP	hsa-miR-6835-3p	96.9165	NM_003685
KHSRP	hsa-miR-4694-3p	95.5919	NM_003685
KHSRP	hsa-miR-4775	94.7729	NM_003685
KHSRP	hsa-miR-3611	93.9319	NM_003685
KHSRP	hsa-miR-7156-5p	92.7221	NM_003685
KHSRP	hsa-miR-3148	92.5505	NM_003685
KHSRP	hsa-miR-3688-3p	92.0335	NM_003685
KHSRP	hsa-miR-4273	92.0319	NM_003685
KHSRP	hsa-miR-12136	91.8457	NM_003685
KHSRP	hsa-miR-9903	91.5985	NM_003685
KHSRP	hsa-miR-6878-5p	91.0408	NM_003685
KHSRP	hsa-miR-1277-5p	88.2425	NM_003685
KHSRP	hsa-miR-5683	87.5639	NM_003685
KHSRP	hsa-miR-4670-3p	86.4416	NM_003685
KHSRP	hsa-miR-561-3p	86.0987	NM_003685
KHSRP	hsa-miR-1245b-3p	85.4209	NM_003685
KHSRP	hsa-miR-3613-3p	85.2402	NM_003685
KHSRP	hsa-miR-27a-3p	85.1762	NM_003685
KHSRP	hsa-miR-27b-3p	85.1762	NM_003685
KHSRP	hsa-miR-4728-5p	84.7597	NM_003685
KHSRP	hsa-miR-6785-5p	82.0187	NM_003685
KHSRP	hsa-miR-589-3p	81.8947	NM_003685
KHSRP	hsa-miR-9985	80.9799	NM_003685
KHSRP	hsa-miR-513a-5p	80.9799	NM_003685
KHSRP	hsa-miR-149-3p	80.6165	NM_003685
KHSRP	hsa-miR-6883-5p	80.6165	NM_003685
KHSRP	hsa-miR-6778-5p	80.3598	NM_003685
KHSRP	hsa-miR-1233-5p	80.3598	NM_003685
KHSRP	hsa-miR-590-3p	80.3322	NM_003685

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Motifs and transcription factors (TFs) regulating KHSRP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KHSRP	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
KHSRP	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
KHSRP	hdpi__ETV4	ETV4 (directAnnotation).
KHSRP	swissregulon__hs__ELF2	ELF2 (directAnnotation).
KHSRP	jaspar__MA0502.2	NFYB (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
KHSRP	"Artenimol"	DB11638	small molecule
KHSRP	"Resveratrol"	DB02709	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."