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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KHDC4

Summary for KHDC4

Gene information	Gene symbol	KHDC4
	Ensembl ID	ENSG00000132680
	Entrez ID	22889
	Gene name	KH domain containing 4, pre-mRNA splicing factor
	Synonyms	BLOM7\|KIAA0907\|SNORA80EHG
	Gene type	protein_coding
	UniProtAcc	Q7Z7F0

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Dataset with differentially expressed gene: KHDC4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.497575	5.14e-03

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Expression of KHDC4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KHDC4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KHDC4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KHDC4	hsa-miR-3158-5p	97.7722	NM_014949
KHDC4	hsa-miR-137-3p	96.9682	NM_014949
KHDC4	hsa-miR-4639-5p	96.9327	NM_014949
KHDC4	hsa-miR-19b-3p	96.3704	NM_014949
KHDC4	hsa-miR-19a-3p	96.3704	NM_014949
KHDC4	hsa-miR-3529-3p	96.0507	NM_014949
KHDC4	hsa-miR-7853-5p	92.5698	NM_014949
KHDC4	hsa-miR-105-5p	92.5698	NM_014949
KHDC4	hsa-miR-509-3-5p	92.4625	NM_014949
KHDC4	hsa-miR-509-5p	92.4625	NM_014949
KHDC4	hsa-miR-4699-3p	92.2954	NM_014949
KHDC4	hsa-miR-4480	90.7425	NM_014949
KHDC4	hsa-miR-8070	90.2798	NM_014949
KHDC4	hsa-miR-6817-3p	89.3767	NM_014949
KHDC4	hsa-miR-4418	88.962	NM_014949
KHDC4	hsa-miR-324-3p	88.8165	NM_014949
KHDC4	hsa-miR-4286	88.2568	NM_014949
KHDC4	hsa-miR-12136	87.6155	NM_014949
KHDC4	hsa-miR-195-3p	86.98	NM_014949
KHDC4	hsa-miR-16-2-3p	86.98	NM_014949
KHDC4	hsa-miR-182-5p	86.9291	NM_014949
KHDC4	hsa-miR-548at-5p	86.374	NM_014949
KHDC4	hsa-miR-3192-5p	85.556	NM_014949
KHDC4	hsa-miR-586	84.9141	NM_014949
KHDC4	hsa-miR-4252	84.6759	NM_014949
KHDC4	hsa-miR-601	84.5106	NM_014949
KHDC4	hsa-miR-298	83.5382	NM_014949
KHDC4	hsa-miR-5582-3p	83.1673	NM_014949
KHDC4	hsa-miR-4328	81.8079	NM_014949
KHDC4	hsa-miR-3194-5p	81.3667	NM_014949
KHDC4	hsa-miR-548aw	81.0855	NM_014949

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Motifs and transcription factors (TFs) regulating KHDC4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."