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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KDM4A

Summary for KDM4A

Gene information	Gene symbol	KDM4A
	Ensembl ID	ENSG00000066135
	Entrez ID	9682
	Gene name	lysine demethylase 4A
	Synonyms	JHDM3A\|JMJD2\|JMJD2A\|KIAA0677\|TDRD14A
	Gene type	protein_coding
	UniProtAcc	O75164

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Dataset with differentially expressed gene: KDM4A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.314382	6.37e-26

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Expression of KDM4A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KDM4A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KDM4A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KDM4A	hsa-miR-3665	97.7293	NM_014663
KDM4A	hsa-miR-6736-3p	96.7325	NM_014663
KDM4A	hsa-miR-3173-5p	94.4102	NM_014663
KDM4A	hsa-miR-6799-3p	94.4102	NM_014663
KDM4A	hsa-miR-7-2-3p	93.7077	NM_014663
KDM4A	hsa-miR-7-1-3p	93.7077	NM_014663
KDM4A	hsa-miR-10526-3p	93.6991	NM_014663
KDM4A	hsa-miR-4725-3p	93.4008	NM_014663
KDM4A	hsa-miR-6780b-5p	93.4008	NM_014663
KDM4A	hsa-miR-4271	93.4008	NM_014663
KDM4A	hsa-miR-137-3p	93.2803	NM_014663
KDM4A	hsa-miR-4639-5p	92.1385	NM_014663
KDM4A	hsa-miR-8485	91.9472	NM_014663
KDM4A	hsa-miR-5002-5p	91.8081	NM_014663
KDM4A	hsa-miR-874-3p	91.7252	NM_014663
KDM4A	hsa-miR-659-3p	91.5721	NM_014663
KDM4A	hsa-miR-29b-2-5p	91.3263	NM_014663
KDM4A	hsa-miR-4255	90.7919	NM_014663
KDM4A	hsa-miR-125a-3p	87.622	NM_014663
KDM4A	hsa-miR-5688	87.1065	NM_014663
KDM4A	hsa-miR-4290	86.9341	NM_014663
KDM4A	hsa-miR-657	86.2609	NM_014663
KDM4A	hsa-miR-495-3p	86.0328	NM_014663
KDM4A	hsa-miR-1224-3p	85.9582	NM_014663
KDM4A	hsa-miR-8080	85.9457	NM_014663
KDM4A	hsa-miR-6787-3p	85.2853	NM_014663
KDM4A	hsa-miR-23a-3p	84.9015	NM_014663
KDM4A	hsa-miR-23b-3p	84.9015	NM_014663
KDM4A	hsa-miR-23c	84.9015	NM_014663
KDM4A	hsa-miR-509-5p	83.4146	NM_014663
KDM4A	hsa-miR-509-3-5p	83.4146	NM_014663
KDM4A	hsa-miR-3130-3p	83.3371	NM_014663
KDM4A	hsa-miR-299-5p	82.1743	NM_014663
KDM4A	hsa-miR-6756-3p	81.4826	NM_014663
KDM4A	hsa-miR-4418	80.2225	NM_014663

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Motifs and transcription factors (TFs) regulating KDM4A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KDM4A	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
KDM4A	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
KDM4A	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
KDM4A	jaspar__MA0502.2	NFYB (directAnnotation).
KDM4A	cisbp__M01863	ZNF711 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."