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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KDELR2

Summary for KDELR2

Gene information	Gene symbol	KDELR2
	Ensembl ID	ENSG00000136240
	Entrez ID	11014
	Gene name	KDEL endoplasmic reticulum protein retention receptor 2
	Synonyms	ELP-1\|ERD2.2
	Gene type	protein_coding
	UniProtAcc	P33947

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Dataset with differentially expressed gene: KDELR2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.46872	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	0.291777	1.20e-02
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.645294	5.47e-05
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	post	Malignant cells	-0.298493	4.36e-05
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.359189	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	0.582368	1.09e-02
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.311059	7.71e-18
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.319271	2.59e-19
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.639764	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.304568	6.35e-13
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.315184	0.00e+00

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Expression of KDELR2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KDELR2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KDELR2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KDELR2	hsa-miR-6844	98.1761	NM_001100603
KDELR2	hsa-miR-3613-3p	98.1622	NM_006854
KDELR2	hsa-miR-192-3p	93.3789	NM_006854
KDELR2	hsa-miR-5683	93.3073	NM_006854
KDELR2	hsa-miR-142-3p	93.0615	NM_006854
KDELR2	hsa-miR-6501-5p	93.0123	NM_001100603
KDELR2	hsa-miR-4330	90.7873	NM_001100603
KDELR2	hsa-miR-607	90.3468	NM_006854
KDELR2	hsa-miR-10524-5p	90.2289	NM_001100603
KDELR2	hsa-miR-4325	89.5936	NM_006854
KDELR2	hsa-miR-557	89.3455	NM_006854
KDELR2	hsa-miR-507	89.0164	NM_006854
KDELR2	hsa-miR-138-5p	88.5095	NM_006854
KDELR2	hsa-miR-1273h-3p	87.3558	NM_006854
KDELR2	hsa-miR-4772-3p	86.1216	NM_006854
KDELR2	hsa-miR-4310	85.0867	NM_001100603
KDELR2	hsa-miR-4779	84.9189	NM_001100603
KDELR2	hsa-miR-374c-5p	83.9221	NM_006854
KDELR2	hsa-miR-655-3p	83.9221	NM_006854
KDELR2	hsa-miR-1265	83.057	NM_001100603
KDELR2	hsa-miR-6133	82.2944	NM_001100603
KDELR2	hsa-miR-4510	82.2944	NM_001100603
KDELR2	hsa-miR-6129	82.2944	NM_001100603
KDELR2	hsa-miR-6130	82.2944	NM_001100603
KDELR2	hsa-miR-6127	82.2944	NM_001100603
KDELR2	hsa-miR-7852-3p	82.0322	NM_006854
KDELR2	hsa-miR-7157-5p	81.9655	NM_001100603

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Motifs and transcription factors (TFs) regulating KDELR2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KDELR2	metacluster_7.13	ZFX (directAnnotation).
KDELR2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
KDELR2	metacluster_151.2	ZNF23 (directAnnotation).
KDELR2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KDELR2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KDELR2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
KDELR2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KDELR2	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
KDELR2	metacluster_52.11	ZNF184 (directAnnotation).
KDELR2	metacluster_7.8	ZBTB7A; ZNF28 (directAnnotation).
KDELR2	taipale_cyt_meth__ELF3_NTGTGCGGATGCN_FL_repr	ELF3 (directAnnotation).
KDELR2	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
KDELR2	flyfactorsurvey__pho_SOLEXA_F1-3	YY1 (inferredBy_Orthology).
KDELR2	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
KDELR2	transfac_pro__M04748	GABPA (directAnnotation).
KDELR2	kznf__ZNF653_Najafabadi2015_ChIP-seq	ZNF653 (directAnnotation).
KDELR2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
KDELR2	transfac_pro__M05441	ZNF396 (directAnnotation).
KDELR2	transfac_pro__M05605	GATA6 (inferredBy_Orthology).
KDELR2	transfac_pro__M04861	SIX5 (directAnnotation).
KDELR2	transfac_pro__M06172	ZNF90 (directAnnotation).
KDELR2	metacluster_139.7	XBP1 (directAnnotation). XBP1 (inferredBy_Orthology).
KDELR2	transfac_pro__M06106	ZNF14 (directAnnotation).
KDELR2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
KDELR2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
KDELR2	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
KDELR2	transfac_pro__M05868	ZNF491 (directAnnotation).
KDELR2	kznf__ZNF791_Imbeault2017_OM_MEME	ZNF791 (directAnnotation).
KDELR2	transfac_pro__M05566	ZSCAN25 (directAnnotation).
KDELR2	metacluster_23.10	FOXO4 (inferredBy_Orthology).
KDELR2	taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_repr	ETV2; HES7 (directAnnotation).
KDELR2	transfac_pro__M05931	ZNF556 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."