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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KCTD3

Summary for KCTD3

Gene information	Gene symbol	KCTD3
	Ensembl ID	ENSG00000136636
	Entrez ID	51133
	Gene name	potassium channel tetramerization domain containing 3
	Synonyms	NY-REN-45
	Gene type	protein_coding
	UniProtAcc	Q9Y597

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Dataset with differentially expressed gene: KCTD3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.309088	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.253131	1.86e-08

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Expression of KCTD3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCTD3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCTD3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCTD3	hsa-miR-3646	97.7067	NM_001319294
KCTD3	hsa-miR-4255	94.583	NM_001319294
KCTD3	hsa-miR-153-5p	94.2614	NM_001319294
KCTD3	hsa-miR-561-3p	93.3963	NM_001319294
KCTD3	hsa-miR-4639-5p	89.507	NM_001319294
KCTD3	hsa-miR-6891-3p	86.1069	NM_001319294
KCTD3	hsa-miR-6072	86.1069	NM_001319294
KCTD3	hsa-miR-122b-5p	85.8863	NM_001319294
KCTD3	hsa-miR-5682	85.8652	NM_001319294
KCTD3	hsa-miR-141-3p	85.4482	NM_001319294
KCTD3	hsa-miR-200a-3p	85.4482	NM_001319294
KCTD3	hsa-miR-190b-3p	84.8553	NM_001319294
KCTD3	hsa-miR-513b-3p	81.1569	NM_001319294
KCTD3	hsa-miR-548m	81.1489	NM_001319294
KCTD3	hsa-miR-4652-3p	80.2825	NM_001319294

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Motifs and transcription factors (TFs) regulating KCTD3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCTD3	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
KCTD3	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
KCTD3	metacluster_172.23	ZBTB32; ZBTB32 (directAnnotation).
KCTD3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
KCTD3	transfac_pro__M00652	NRF1 (directAnnotation).
KCTD3	transfac_pro__M04866	HDAC2 (directAnnotation).
KCTD3	jaspar__MA1122.1	TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."