DRMref Logo

Home

Download

Statistics

Landscape

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Datasets with differential expression of this gene

leaf

Expression of this gene in the resistant group across all datasets and cell types

leaf

Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

leaf

Known drug resistance mechanisms of this gene (This gene does not contain this module)

leaf

MicroRNAs (miRNAs) regulating this gene

leaf

Motifs and transcription factors (TFs) regulating this gene

leaf

Acts as a transcription factor (This gene does not contain this module)

leaf

Acts as a drug target< (This gene does not contain this module)

Gene: KCTD20

Summary for KCTD20

Gene informationGene symbol

KCTD20

Ensembl ID

ENSG00000112078

Entrez ID

222658

Gene namepotassium channel tetramerization domain containing 20
SynonymsC6orf69|dJ108K11.3|MGC14254
Gene typeprotein_coding
UniProtAcc

Q7Z5Y7


Top

Dataset with differentially expressed gene: KCTD20

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells0.3054162.65e-20

GSE139386

H3122 cell lineCell lineLung cancerEML4-ALK fusion-positive non-small cell lung cancer (NSCLC)Targeted therapyceritinibNAMalignant cells-0.3061370.00e+00

Top

Expression of KCTD20 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

Top

Significant ligand-receptor pairs related to KCTD20

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating KCTD20

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
KCTD20hsa-miR-6757-3p95.9056NM_001286579
KCTD20hsa-miR-141-3p92.9257NM_001286579
KCTD20hsa-miR-200a-3p92.9257NM_001286579
KCTD20hsa-miR-477392.7648NM_001286580
KCTD20hsa-miR-808091.3906NM_001286579
KCTD20hsa-miR-127591.3115NM_001286580
KCTD20hsa-miR-6768-5p91.2455NM_001286580
KCTD20hsa-miR-4797-5p90.8149NM_001286580
KCTD20hsa-miR-374a-5p89.7927NM_001286580
KCTD20hsa-miR-378g88.8565NM_001286580
KCTD20hsa-miR-4423-3p87.9104NM_001286579
KCTD20hsa-miR-6807-3p87.7444NM_001286580
KCTD20hsa-miR-217-5p87.2642NM_001286580
KCTD20hsa-miR-29a-3p86.4265NM_001286579
KCTD20hsa-miR-29b-3p86.4265NM_001286579
KCTD20hsa-miR-29c-3p86.4265NM_001286579
KCTD20hsa-miR-52786.4167NM_001286580
KCTD20hsa-miR-518a-5p86.4167NM_001286580
KCTD20hsa-miR-31-5p86.3658NM_001286579
KCTD20hsa-miR-374b-5p86.1555NM_001286580
KCTD20hsa-miR-477585.9619NM_001286580
KCTD20hsa-miR-607284.6104NM_001286580
KCTD20hsa-miR-324-5p84.5449NM_001286580
KCTD20hsa-miR-4665-5p84.5132NM_001286580
KCTD20hsa-miR-133a-3p83.8301NM_001286579
KCTD20hsa-miR-133b83.8301NM_001286579
KCTD20hsa-miR-5692c83.7492NM_001286580
KCTD20hsa-miR-5692b83.7492NM_001286580
KCTD20hsa-miR-430381.389NM_001286580
KCTD20hsa-miR-6891-3p80.6085NM_001286580
KCTD20hsa-miR-498-3p80.5714NM_001286579
Page: 1

Top

Motifs and transcription factors (TFs) regulating KCTD20

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
KCTD20metacluster_191.2ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
KCTD20metacluster_55.3E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
KCTD20taipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
KCTD20dbtfbs__E2F8_representative_N1E2F8 (directAnnotation).
KCTD20jaspar__MA1483.2ELF2 (directAnnotation).
KCTD20metacluster_15.3E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
KCTD20transfac_pro__M04826EP300 (directAnnotation).
KCTD20metacluster_191.3EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
KCTD20taipale_tf_pairs__ETV2_HES7_NNCACGTGNNNNNCGGAWRY_CAP_reprETV2; HES7 (directAnnotation).
KCTD20taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_reprE2F2 (directAnnotation).
KCTD20taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methZNF385D (directAnnotation).
KCTD20taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_reprERF; HES7 (directAnnotation).
KCTD20metacluster_197.2E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
KCTD20taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
KCTD20cisbp__M08198ELF1 (directAnnotation).
KCTD20transfac_pro__M00652NRF1 (directAnnotation).
KCTD20hdpi__ETV4ETV4 (directAnnotation).
KCTD20taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_reprE2F1; HES7 (directAnnotation).
KCTD20transfac_pro__M04866HDAC2 (directAnnotation).
KCTD20jaspar__MA1122.1TFDP1 (directAnnotation).
KCTD20metacluster_166.4BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
KCTD20taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HTELK1; HOXA1 (directAnnotation).
KCTD20metacluster_34.1ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
KCTD20swissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
KCTD20metacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
KCTD20metacluster_144.8ZNF30; ZNF30 (directAnnotation).
KCTD20transfac_pro__M04918EGR1 (directAnnotation).
KCTD20metacluster_7.13ZFX (directAnnotation).
KCTD20metacluster_144.3ZNF704; ZNF704 (directAnnotation).
KCTD20tfdimers__MD00154MZF1; SREBF1 (directAnnotation).
KCTD20kznf__ZNF730_Imbeault2017_RP_RCADEZNF730 (directAnnotation).
KCTD20transfac_pro__M01219SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KCTD20metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KCTD20cisbp__M01863ZNF711 (inferredBy_Orthology).
KCTD20taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_reprELF1; GCM1 (directAnnotation).
KCTD20homer__GGCGGGAARN_E2F6E2F6 (directAnnotation).
KCTD20taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_methZNF460 (directAnnotation).
KCTD20kznf__ZNF571_Imbeault2017_OM_RCADEZNF571 (directAnnotation).
KCTD20taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_reprKLF12 (directAnnotation).
KCTD20transfac_pro__M05432ZSCAN18 (directAnnotation).
Page: 1

Top

Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."