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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KCTD1

Summary for KCTD1

Gene information	Gene symbol	KCTD1
	Ensembl ID	ENSG00000134504
	Entrez ID	284252
	Gene name	potassium channel tetramerization domain containing 1
	Synonyms	C18orf5
	Gene type	protein_coding
	UniProtAcc	Q719H9

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Dataset with differentially expressed gene: KCTD1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.348548	0.00e+00

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Expression of KCTD1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCTD1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCTD1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCTD1	hsa-miR-190a-3p	99.9884	NM_001136205
KCTD1	hsa-miR-5011-5p	99.9679	NM_001136205
KCTD1	hsa-miR-651-3p	99.1066	NM_001258221
KCTD1	hsa-miR-3680-3p	98.6632	NM_001136205
KCTD1	hsa-miR-655-3p	95.6103	NM_001258221
KCTD1	hsa-miR-374c-5p	95.6103	NM_001258221
KCTD1	hsa-miR-4797-5p	95.3279	NM_001136205
KCTD1	hsa-miR-450b-5p	95.2455	NM_001136205
KCTD1	hsa-miR-9983-3p	94.779	NM_001258221
KCTD1	hsa-miR-507	94.2918	NM_001136205
KCTD1	hsa-miR-3148	93.3361	NM_001258221
KCTD1	hsa-miR-129-5p	93.1616	NM_001258221
KCTD1	hsa-miR-8071	92.8887	NM_001136205
KCTD1	hsa-miR-557	92.3597	NM_001136205
KCTD1	hsa-miR-4711-3p	92.309	NM_001136205
KCTD1	hsa-miR-3163	91.9184	NM_001258221
KCTD1	hsa-miR-3685	91.8867	NM_001136205
KCTD1	hsa-miR-4282	91.6159	NM_001258221
KCTD1	hsa-miR-6834-3p	89.705	NM_001136205
KCTD1	hsa-miR-6832-3p	89.2416	NM_001258221
KCTD1	hsa-miR-4528	89.1872	NM_001258221
KCTD1	hsa-miR-4761-5p	85.4528	NM_001136205
KCTD1	hsa-miR-3606-3p	85.2842	NM_001258221
KCTD1	hsa-miR-513c-3p	85.2842	NM_001258221
KCTD1	hsa-miR-513a-3p	85.2842	NM_001258221
KCTD1	hsa-miR-448	84.6522	NM_001136205
KCTD1	hsa-miR-4328	83.6921	NM_001258221
KCTD1	hsa-miR-514b-3p	81.8946	NM_001258221
KCTD1	hsa-miR-514a-3p	81.8946	NM_001258221
KCTD1	hsa-miR-6847-3p	81.5736	NM_001258221
KCTD1	hsa-miR-6134	81.5523	NM_001258221
KCTD1	hsa-miR-153-3p	81.4819	NM_001136205
KCTD1	hsa-miR-6747-3p	81.4545	NM_001136205

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Motifs and transcription factors (TFs) regulating KCTD1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCTD1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
KCTD1	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
KCTD1	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
KCTD1	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
KCTD1	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
KCTD1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
KCTD1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
KCTD1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
KCTD1	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
KCTD1	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
KCTD1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
KCTD1	hdpi__ETV4	ETV4 (directAnnotation).
KCTD1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
KCTD1	transfac_pro__M04866	HDAC2 (directAnnotation).
KCTD1	jaspar__MA1122.1	TFDP1 (directAnnotation).
KCTD1	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
KCTD1	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
KCTD1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."