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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KCNS3

Summary for KCNS3

Gene information	Gene symbol	KCNS3
	Ensembl ID	ENSG00000170745
	Entrez ID	3790
	Gene name	potassium voltage-gated channel modifier subfamily S member 3
	Synonyms	Kv9.3
	Gene type	protein_coding
	UniProtAcc	Q9BQ31

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Dataset with differentially expressed gene: KCNS3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.725434	0.00e+00

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Expression of KCNS3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCNS3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCNS3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCNS3	hsa-miR-125b-5p	97.2245	NM_001282428
KCNS3	hsa-miR-125a-5p	97.2245	NM_001282428
KCNS3	hsa-miR-4319	97.1125	NM_001282428
KCNS3	hsa-miR-3620-3p	95.6677	NM_001282428
KCNS3	hsa-miR-4666a-5p	93.6435	NM_001282428
KCNS3	hsa-miR-4324	93.1662	NM_001282428
KCNS3	hsa-miR-889-5p	93.0803	NM_001282428
KCNS3	hsa-miR-340-5p	91.0255	NM_002252
KCNS3	hsa-miR-135a-5p	90.5648	NM_001282428
KCNS3	hsa-miR-135b-5p	90.5648	NM_001282428
KCNS3	hsa-miR-3919	90.1875	NM_002252
KCNS3	hsa-miR-4716-5p	89.3642	NM_001282428
KCNS3	hsa-miR-580-3p	89.3273	NM_001282428
KCNS3	hsa-miR-513c-3p	88.2337	NM_002252
KCNS3	hsa-miR-513a-3p	88.2337	NM_002252
KCNS3	hsa-miR-3910	87.0277	NM_001282428
KCNS3	hsa-miR-320b	86.8427	NM_002252
KCNS3	hsa-miR-320c	86.8427	NM_002252
KCNS3	hsa-miR-4429	86.8427	NM_002252
KCNS3	hsa-miR-320a-3p	86.8427	NM_002252
KCNS3	hsa-miR-320d	86.8427	NM_002252
KCNS3	hsa-miR-589-3p	86.5068	NM_002252
KCNS3	hsa-miR-205-3p	86.305	NM_002252
KCNS3	hsa-miR-3942-3p	85.7218	NM_002252
KCNS3	hsa-miR-3606-3p	84.294	NM_002252
KCNS3	hsa-miR-9-3p	83.1281	NM_001282428
KCNS3	hsa-miR-4251	81.4861	NM_001282428

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Motifs and transcription factors (TFs) regulating KCNS3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCNS3	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
KCNS3	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
KCNS3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
KCNS3	jaspar__MA1122.1	TFDP1 (directAnnotation).
KCNS3	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."