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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: KCNN4

Summary for KCNN4

Gene information	Gene symbol	KCNN4
	Ensembl ID	ENSG00000104783
	Entrez ID	3783
	Gene name	potassium calcium-activated channel subfamily N member 4
	Synonyms	hIKCa1\|hKCa4\|hSK4\|IK\|KCa3.1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KCNN4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.255377	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.459678	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.394785	0.00e+00

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Expression of KCNN4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCNN4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCNN4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCNN4	hsa-miR-520d-5p	96.7179	NM_002250
KCNN4	hsa-miR-524-5p	96.7179	NM_002250
KCNN4	hsa-miR-4524a-5p	94.4724	NM_002250
KCNN4	hsa-miR-4524b-5p	94.4724	NM_002250
KCNN4	hsa-miR-6504-3p	93.9714	NM_002250
KCNN4	hsa-miR-10399-5p	93.9714	NM_002250
KCNN4	hsa-miR-556-3p	92.3704	NM_002250
KCNN4	hsa-miR-4729	91.4653	NM_002250
KCNN4	hsa-miR-103a-3p	88.0642	NM_002250
KCNN4	hsa-miR-107	88.0642	NM_002250
KCNN4	hsa-miR-15b-5p	86.3783	NM_002250
KCNN4	hsa-miR-195-5p	86.3783	NM_002250
KCNN4	hsa-miR-16-5p	86.3783	NM_002250
KCNN4	hsa-miR-15a-5p	86.3783	NM_002250
KCNN4	hsa-miR-875-3p	83.6768	NM_002250
KCNN4	hsa-miR-497-5p	83.4104	NM_002250
KCNN4	hsa-miR-424-5p	83.4104	NM_002250
KCNN4	hsa-miR-6838-5p	83.4104	NM_002250
KCNN4	hsa-miR-302c-5p	82.8405	NM_002250
KCNN4	hsa-miR-3143	81.298	NM_002250

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Motifs and transcription factors (TFs) regulating KCNN4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCNN4	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
KCNN4	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
KCNN4	metacluster_22.34	BACH2 (directAnnotation).
KCNN4	metacluster_22.37	BACH1 (directAnnotation).
KCNN4	metacluster_22.18	BACH2 (inferredBy_Orthology).
KCNN4	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
KCNN4	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
KCNN4	tfdimers__MD00561	CRX (directAnnotation).
KCNN4	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
KCNN4	jaspar__MA1483.2	ELF2 (directAnnotation).
KCNN4	jaspar__MA1933.1	SREBF2 (directAnnotation).
KCNN4	swissregulon__hs__ETV6	ETV6 (directAnnotation).
KCNN4	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
KCNN4	cisbp__M08198	ELF1 (directAnnotation).
KCNN4	hdpi__ETV4	ETV4 (directAnnotation).
KCNN4	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
KCNN4	jaspar__MA1708.1	ETV7 (directAnnotation).
KCNN4	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
KCNN4	transfac_pro__M04748	GABPA (directAnnotation).
KCNN4	cisbp__M02645	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
KCNN4	"Clotrimazole"	DB00257	small molecule
KCNN4	"Halothane"	DB01159	small molecule
KCNN4	"Quinine"	DB00468	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."