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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: KCNN3

Summary for KCNN3

Gene information	Gene symbol	KCNN3
	Ensembl ID	ENSG00000143603
	Entrez ID	3782
	Gene name	potassium calcium-activated channel subfamily N member 3
	Synonyms	hSK3\|KCa2.3\|SKCA3
	Gene type	protein_coding
	UniProtAcc	Q9UGI6

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Dataset with differentially expressed gene: KCNN3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.88218	2.94e-03
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	-0.261703	0.00e+00

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Expression of KCNN3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCNN3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCNN3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCNN3	hsa-miR-5011-5p	99.9999	NM_170782
KCNN3	hsa-miR-190a-3p	99.9992	NM_170782
KCNN3	hsa-miR-3119	99.6211	NM_001204087
KCNN3	hsa-miR-4795-3p	99.1259	NM_170782
KCNN3	hsa-miR-570-3p	99.03	NM_170782
KCNN3	hsa-miR-135b-5p	98.4775	NM_001204087
KCNN3	hsa-miR-135a-5p	98.4775	NM_001204087
KCNN3	hsa-miR-507	96.6796	NM_170782
KCNN3	hsa-miR-4324	96.192	NM_001204087
KCNN3	hsa-miR-557	95.4319	NM_170782
KCNN3	hsa-miR-4306	95.0505	NM_170782
KCNN3	hsa-miR-892a	94.9252	NM_170782
KCNN3	hsa-miR-126-5p	94.6246	NM_170782
KCNN3	hsa-miR-504-3p	94.4733	NM_170782
KCNN3	hsa-miR-665	94.0104	NM_001204087
KCNN3	hsa-miR-4693-5p	93.6533	NM_170782
KCNN3	hsa-miR-6513-3p	93.5534	NM_001204087
KCNN3	hsa-miR-3680-3p	91.8851	NM_170782
KCNN3	hsa-miR-548c-3p	91.2411	NM_170782
KCNN3	hsa-miR-6867-5p	90.8909	NM_001204087
KCNN3	hsa-miR-432-5p	90.6165	NM_170782
KCNN3	hsa-miR-12136	90.0946	NM_001204087
KCNN3	hsa-miR-122-5p	89.3902	NM_170782
KCNN3	hsa-miR-483-3p	89.2687	NM_170782
KCNN3	hsa-miR-4747-5p	88.9299	NM_170782
KCNN3	hsa-miR-5196-5p	88.9299	NM_170782
KCNN3	hsa-miR-6505-5p	88.447	NM_170782
KCNN3	hsa-miR-561-5p	88.2806	NM_001204087
KCNN3	hsa-miR-5582-3p	88.0255	NM_170782
KCNN3	hsa-miR-5186	87.7094	NM_001204087
KCNN3	hsa-miR-128-3p	87.6401	NM_001204087
KCNN3	hsa-miR-216a-3p	87.6401	NM_001204087
KCNN3	hsa-miR-499a-5p	87.4082	NM_170782
KCNN3	hsa-miR-766-3p	87.3999	NM_170782
KCNN3	hsa-miR-651-3p	86.9213	NM_001204087
KCNN3	hsa-miR-3663-5p	86.8405	NM_170782
KCNN3	hsa-miR-4644	86.8104	NM_170782
KCNN3	hsa-miR-185-5p	86.8104	NM_170782
KCNN3	hsa-miR-2117	86.6819	NM_170782
KCNN3	hsa-miR-5683	86.3391	NM_001204087
KCNN3	hsa-miR-338-5p	85.8611	NM_170782
KCNN3	hsa-miR-498-3p	85.8486	NM_001204087
KCNN3	hsa-miR-664b-3p	85.7726	NM_170782
KCNN3	hsa-miR-579-3p	85.7726	NM_170782
KCNN3	hsa-miR-656-3p	85.2181	NM_170782
KCNN3	hsa-miR-6504-5p	84.9323	NM_001204087
KCNN3	hsa-miR-3085-3p	84.9323	NM_001204087
KCNN3	hsa-miR-3064-5p	84.9323	NM_001204087
KCNN3	hsa-miR-4279	84.6327	NM_170782
KCNN3	hsa-miR-149-5p	84.5813	NM_001204087

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Motifs and transcription factors (TFs) regulating KCNN3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCNN3	metacluster_2.8	IRF4; IRF5; IRF6; IRF9 (directAnnotation). IRF3; IRF5; IRF5; IRF6 (inferredBy_Orthology).
KCNN3	metacluster_21.5	HOXB2; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4 (directAnnotation). HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF1; HSF2; HSF2; HSF2; HSF2; HSF4; HSF4; HSF4; HSF4; HSF5; HSF5; HSF5; HSF5; HSFX1; HSFX1; HSFX1; HSFX1; HSFX2; HSFX2; HSFX2; HSFX2; HSFX3; HSFX3; HSFX3; HSFX3; HSFX4; HSFX4; HSFX4; HSFX4; HSFY1; HSFY1; HSFY1; HSFY1; HSFY2; HSFY2; HSFY2; HSFY2 (inferredBy_Orthology).
KCNN3	transfac_pro__M05440	NKX2-3 (directAnnotation).
KCNN3	transfac_pro__M06292	ZNF766 (directAnnotation).
KCNN3	metacluster_161.27	LHX4 (directAnnotation).
KCNN3	tfdimers__MD00602	MYB; STAT6 (directAnnotation).
KCNN3	metacluster_56.4	HSF1; HSF2; HSF2; HSF4 (directAnnotation).
KCNN3	metacluster_161.26	ALX4 (directAnnotation).
KCNN3	metacluster_56.5	HSF1; HSF1; HSF2 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
KCNN3	metacluster_161.31	PRRX2 (directAnnotation).
KCNN3	metacluster_141.2	E2F2; E2F3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
KCNN3	"Dequalinium"	DB04209	small molecule
KCNN3	"Rimtuzalcap"	DB16733	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."