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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: KCNN2

Summary for KCNN2

Gene information	Gene symbol	KCNN2
	Ensembl ID	ENSG00000080709
	Entrez ID	3781
	Gene name	potassium calcium-activated channel subfamily N member 2
	Synonyms	hSK2\|KCa2.2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KCNN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.795163	0.00e+00

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Expression of KCNN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCNN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCNN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCNN2	hsa-miR-4703-5p	96.4195	NM_021614
KCNN2	hsa-miR-3942-5p	95.0368	NM_021614
KCNN2	hsa-miR-1264	93.8765	NM_001278204
KCNN2	hsa-miR-4766-5p	92.8925	NM_021614
KCNN2	hsa-miR-6085	89.5694	NM_021614
KCNN2	hsa-miR-6813-5p	89.5694	NM_021614
KCNN2	hsa-miR-3606-5p	85.3277	NM_021614
KCNN2	hsa-miR-1244	84.8786	NM_001278204

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Motifs and transcription factors (TFs) regulating KCNN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCNN2	transfac_pro__M02089	E2F3 (directAnnotation).
KCNN2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
KCNN2	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
KCNN2	transfac_pro__M04817	ZBTB33 (directAnnotation).
KCNN2	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
KCNN2	tfdimers__MD00483	ZBTB14 (directAnnotation).
KCNN2	cisbp__M07938	E2F1 (directAnnotation).
KCNN2	cisbp__M00968	MTF2 (directAnnotation).
KCNN2	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
KCNN2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
KCNN2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
KCNN2	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
KCNN2	"Rimtuzalcap"	DB16733	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."