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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: KCNA3

Summary for KCNA3

Gene information	Gene symbol	KCNA3
	Ensembl ID	ENSG00000177272
	Entrez ID	3738
	Gene name	potassium voltage-gated channel subfamily A member 3
	Synonyms	HLK3\|HPCN3\|Kv1.3\|MK3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KCNA3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Plasma cells	0.309052	1.21e-02
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.261489	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.28097	0.00e+00

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Expression of KCNA3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCNA3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCNA3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCNA3	hsa-miR-6882-5p	91.6324	NM_002232
KCNA3	hsa-miR-4790-3p	88.978	NM_002232
KCNA3	hsa-miR-12119	85.4156	NM_002232
KCNA3	hsa-miR-6769b-5p	85.0294	NM_002232
KCNA3	hsa-miR-95-5p	85.0153	NM_002232
KCNA3	hsa-miR-211-5p	84.7071	NM_002232
KCNA3	hsa-miR-204-5p	84.7071	NM_002232
KCNA3	hsa-miR-4497	83.1041	NM_002232
KCNA3	hsa-miR-5093	82.6244	NM_002232
KCNA3	hsa-miR-6769a-5p	80.4174	NM_002232

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Motifs and transcription factors (TFs) regulating KCNA3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCNA3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
KCNA3	hdpi__NRL	NRL (directAnnotation).
KCNA3	transfac_pro__M07310	SP5 (directAnnotation).
KCNA3	cisbp__M07938	E2F1 (directAnnotation).
KCNA3	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
KCNA3	cisbp__M00968	MTF2 (directAnnotation).
KCNA3	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
KCNA3	transfac_pro__M04817	ZBTB33 (directAnnotation).
KCNA3	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
KCNA3	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
KCNA3	tfdimers__MD00483	ZBTB14 (directAnnotation).
KCNA3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
KCNA3	transfac_pro__M02089	E2F3 (directAnnotation).
KCNA3	transfac_pro__M07317	CTBP1 (directAnnotation).
KCNA3	transfac_pro__M12697	ZNF142 (directAnnotation).
KCNA3	transfac_pro__M00716	ZBTB14 (directAnnotation).
KCNA3	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
KCNA3	transfac_pro__M03806	ZBTB7C (directAnnotation).
KCNA3	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
KCNA3	transfac_pro__M04893	TAF1 (directAnnotation).
KCNA3	transfac_pro__M01253	CNOT3 (directAnnotation).
KCNA3	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
KCNA3	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
KCNA3	transfac_pro__M04916	TAF1 (directAnnotation).
KCNA3	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
KCNA3	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
KCNA3	hdpi__RARA	RARA (directAnnotation).
KCNA3	hdpi__HTATIP2	HTATIP2 (directAnnotation).
KCNA3	jaspar__MA1650.1	ZBTB14 (directAnnotation).
KCNA3	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
KCNA3	hdpi__HIP2	UBE2K (directAnnotation).
KCNA3	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
KCNA3	hdpi__ZNF304	ZNF304 (directAnnotation).
KCNA3	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
KCNA3	cisbp__M08228	PAX5 (directAnnotation).
KCNA3	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
KCNA3	transfac_pro__M00938	E2F1 (directAnnotation).
KCNA3	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
KCNA3	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
KCNA3	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KCNA3	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
KCNA3	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
KCNA3	cisbp__M00788	ZFY (inferredBy_Orthology).
KCNA3	metacluster_24.3	DIDO1; HINFP; ILF3; ZBTB21; ZFX; ZFX; ZNF283; ZNF37A; ZNF501; ZNF614 (directAnnotation). ZFY; ZFY (inferredBy_Orthology).
KCNA3	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
KCNA3	metacluster_126.7	CTCF; ZFY; ZSCAN30 (directAnnotation).
KCNA3	transfac_pro__M02090	E2F4 (directAnnotation).
KCNA3	transfac_pro__M03846	SMAD5 (directAnnotation).
KCNA3	metacluster_45.4	E2F2 (directAnnotation).
KCNA3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
KCNA3	"Clofazimine"	DB00845	small molecule
KCNA3	"Dalfampridine"	DB06637	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."