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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KCMF1

Summary for KCMF1

Gene information	Gene symbol	KCMF1
	Ensembl ID	ENSG00000176407
	Entrez ID	56888
	Gene name	potassium channel modulatory factor 1
	Synonyms	DEBT91\|DKFZP434L1021\|PCMF\|ZZZ1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KCMF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.526073	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.259971	1.33e-06
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.355933	0.00e+00

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Expression of KCMF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KCMF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KCMF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KCMF1	hsa-miR-12123	99.5238	NM_020122
KCMF1	hsa-miR-6505-3p	96.7363	NM_020122
KCMF1	hsa-miR-4288	95.6967	NM_020122
KCMF1	hsa-miR-6740-3p	95.5621	NM_020122
KCMF1	hsa-miR-3646	95.4038	NM_020122
KCMF1	hsa-miR-5688	95.1861	NM_020122
KCMF1	hsa-miR-495-3p	94.3628	NM_020122
KCMF1	hsa-miR-632	93.3588	NM_020122
KCMF1	hsa-miR-4700-3p	93.356	NM_020122
KCMF1	hsa-miR-6733-5p	93.2583	NM_020122
KCMF1	hsa-miR-6739-5p	93.2583	NM_020122
KCMF1	hsa-miR-548ao-5p	92.764	NM_020122
KCMF1	hsa-miR-548ax	92.764	NM_020122
KCMF1	hsa-miR-5692a	92.7421	NM_020122
KCMF1	hsa-miR-4775	92.6516	NM_020122
KCMF1	hsa-miR-346	92.209	NM_020122
KCMF1	hsa-miR-877-3p	92.0915	NM_020122
KCMF1	hsa-miR-5011-5p	91.3717	NM_020122
KCMF1	hsa-miR-664a-3p	91.3064	NM_020122
KCMF1	hsa-miR-3153	91.2778	NM_020122
KCMF1	hsa-miR-548x-3p	91.1589	NM_020122
KCMF1	hsa-miR-548aj-3p	91.1589	NM_020122
KCMF1	hsa-miR-3622b-3p	91.1465	NM_020122
KCMF1	hsa-miR-3622a-3p	91.1465	NM_020122
KCMF1	hsa-miR-4735-3p	91.0654	NM_020122
KCMF1	hsa-miR-548j-3p	90.8727	NM_020122
KCMF1	hsa-miR-548aq-3p	90.8727	NM_020122
KCMF1	hsa-miR-548ae-3p	90.8727	NM_020122
KCMF1	hsa-miR-548ah-3p	90.8727	NM_020122
KCMF1	hsa-miR-548am-3p	90.8727	NM_020122
KCMF1	hsa-miR-4666b	90.3935	NM_020122
KCMF1	hsa-miR-132-3p	89.8799	NM_020122
KCMF1	hsa-miR-212-3p	89.8799	NM_020122
KCMF1	hsa-miR-5093	89.4584	NM_020122
KCMF1	hsa-miR-18a-5p	89.3287	NM_020122
KCMF1	hsa-miR-18b-5p	89.3287	NM_020122
KCMF1	hsa-miR-3140-5p	88.6748	NM_020122
KCMF1	hsa-miR-12117	88.6628	NM_020122
KCMF1	hsa-miR-1468-3p	87.5852	NM_020122
KCMF1	hsa-miR-4711-3p	87.1274	NM_020122
KCMF1	hsa-miR-379-3p	87.0681	NM_020122
KCMF1	hsa-miR-411-3p	87.0681	NM_020122
KCMF1	hsa-miR-95-5p	86.5424	NM_020122
KCMF1	hsa-miR-4328	85.7153	NM_020122
KCMF1	hsa-miR-3159	85.224	NM_020122
KCMF1	hsa-miR-496	85.064	NM_020122
KCMF1	hsa-miR-302c-5p	84.9736	NM_020122
KCMF1	hsa-miR-7847-3p	84.1484	NM_020122
KCMF1	hsa-miR-576-5p	83.0541	NM_020122
KCMF1	hsa-miR-6833-3p	82.5315	NM_020122

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Motifs and transcription factors (TFs) regulating KCMF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KCMF1	metacluster_7.13	ZFX (directAnnotation).
KCMF1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
KCMF1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
KCMF1	jaspar__MA1483.2	ELF2 (directAnnotation).
KCMF1	metacluster_151.2	ZNF23 (directAnnotation).
KCMF1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
KCMF1	transfac_pro__M05479	ZNF580 (directAnnotation).
KCMF1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KCMF1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
KCMF1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KCMF1	metacluster_182.10	ZFX (directAnnotation).
KCMF1	hdpi__ETV4	ETV4 (directAnnotation).
KCMF1	jaspar__MA0748.2	YY2 (directAnnotation).
KCMF1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
KCMF1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KCMF1	jaspar__MA0079.5	SP1 (directAnnotation).
KCMF1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
KCMF1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
KCMF1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
KCMF1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KCMF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KCMF1	cisbp__M00249	WT1 (directAnnotation).
KCMF1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
KCMF1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
KCMF1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KCMF1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
KCMF1	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
KCMF1	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
KCMF1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
KCMF1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
KCMF1	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
KCMF1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
KCMF1	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
KCMF1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
KCMF1	jaspar__MA1708.1	ETV7 (directAnnotation).
KCMF1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
KCMF1	hdpi__ELF2	ELF2 (directAnnotation).
KCMF1	swissregulon__hs__ELK1	ELK1 (directAnnotation).
KCMF1	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
KCMF1	metacluster_183.4	ETS1 (inferredBy_Orthology).
KCMF1	metacluster_81.7	CREB1 (directAnnotation).
KCMF1	taipale_tf_pairs__ETV5_HOXB13_NNCGGANGNNNTWAA_CAP	ETV5; HOXB13 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."