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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KATNBL1

Summary for KATNBL1

Gene information	Gene symbol	KATNBL1
	Ensembl ID	ENSG00000134152
	Entrez ID	79768
	Gene name	katanin regulatory subunit B1 like 1
	Synonyms	C15orf29\|FLJ22557
	Gene type	protein_coding
	UniProtAcc	Q9H079

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Dataset with differentially expressed gene: KATNBL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.339515	1.02e-02
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.293973	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.281321	0.00e+00

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Expression of KATNBL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KATNBL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KATNBL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KATNBL1	hsa-miR-199a-3p	98.8143	NM_024713
KATNBL1	hsa-miR-3129-5p	98.8143	NM_024713
KATNBL1	hsa-miR-199b-3p	98.8143	NM_024713
KATNBL1	hsa-miR-3163	98.4955	NM_024713
KATNBL1	hsa-miR-12136	98.2672	NM_024713
KATNBL1	hsa-miR-1305	97.9635	NM_024713
KATNBL1	hsa-miR-4262	96.9913	NM_024713
KATNBL1	hsa-miR-3613-3p	96.2616	NM_024713
KATNBL1	hsa-miR-5584-3p	95.9771	NM_024713
KATNBL1	hsa-miR-485-3p	95.2059	NM_024713
KATNBL1	hsa-miR-539-3p	95.2059	NM_024713
KATNBL1	hsa-miR-181c-5p	94.796	NM_024713
KATNBL1	hsa-miR-181b-5p	94.796	NM_024713
KATNBL1	hsa-miR-181d-5p	94.796	NM_024713
KATNBL1	hsa-miR-181a-5p	94.796	NM_024713
KATNBL1	hsa-miR-4460	94.6529	NM_024713
KATNBL1	hsa-miR-6771-3p	93.9013	NM_024713
KATNBL1	hsa-miR-514b-5p	93.89	NM_024713
KATNBL1	hsa-miR-513c-5p	93.89	NM_024713
KATNBL1	hsa-miR-4436b-5p	93.6409	NM_024713
KATNBL1	hsa-miR-4756-3p	93.1265	NM_024713
KATNBL1	hsa-miR-6073	92.8493	NM_024713
KATNBL1	hsa-miR-5680	92.626	NM_024713
KATNBL1	hsa-miR-140-5p	92.1433	NM_024713
KATNBL1	hsa-miR-3168	91.619	NM_024713
KATNBL1	hsa-miR-509-3p	90.8852	NM_024713
KATNBL1	hsa-miR-888-5p	90.8524	NM_024713
KATNBL1	hsa-miR-148b-5p	90.5886	NM_024713
KATNBL1	hsa-miR-6874-3p	90.5886	NM_024713
KATNBL1	hsa-miR-3910	90.4346	NM_024713
KATNBL1	hsa-miR-4448	90.2152	NM_024713
KATNBL1	hsa-miR-548e-5p	89.9912	NM_024713
KATNBL1	hsa-miR-2052	89.0398	NM_024713
KATNBL1	hsa-miR-3119	88.9382	NM_024713
KATNBL1	hsa-miR-5187-5p	88.0404	NM_024713
KATNBL1	hsa-miR-6875-3p	88.0299	NM_024713
KATNBL1	hsa-miR-10527-5p	87.9614	NM_024713
KATNBL1	hsa-miR-4699-3p	87.8381	NM_024713
KATNBL1	hsa-miR-3180-5p	86.6771	NM_024713
KATNBL1	hsa-miR-29b-2-5p	85.4114	NM_024713
KATNBL1	hsa-miR-3128	85.1832	NM_024713
KATNBL1	hsa-miR-548j-5p	84.9232	NM_024713
KATNBL1	hsa-miR-548ab	84.9232	NM_024713
KATNBL1	hsa-miR-548a-5p	84.9232	NM_024713
KATNBL1	hsa-miR-548ak	84.9232	NM_024713
KATNBL1	hsa-miR-548d-5p	84.9232	NM_024713
KATNBL1	hsa-miR-548b-5p	84.9232	NM_024713
KATNBL1	hsa-miR-548o-5p	84.9232	NM_024713
KATNBL1	hsa-miR-548ae-5p	84.9232	NM_024713
KATNBL1	hsa-miR-548w	84.9232	NM_024713

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Motifs and transcription factors (TFs) regulating KATNBL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KATNBL1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
KATNBL1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
KATNBL1	transfac_pro__M00652	NRF1 (directAnnotation).
KATNBL1	hdpi__ETV4	ETV4 (directAnnotation).
KATNBL1	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
KATNBL1	transfac_pro__M04866	HDAC2 (directAnnotation).
KATNBL1	jaspar__MA1122.1	TFDP1 (directAnnotation).
KATNBL1	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
KATNBL1	taipale_tf_pairs__TFAP2C_MAX_TNSCCNNNGGSNNNCACGTGN_CAP_repr	MAX; TFAP2C (directAnnotation).
KATNBL1	transfac_pro__M04826	EP300 (directAnnotation).
KATNBL1	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
KATNBL1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
KATNBL1	tfdimers__MD00148	CHURC1; ZBTB7A (directAnnotation).
KATNBL1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
KATNBL1	taipale_tf_pairs__ETV7_TBX21_NSCGGAARNNNNNTCACACNN_CAP_repr	ETV7; TBX21 (directAnnotation).
KATNBL1	metacluster_80.6	ZIC4 (directAnnotation).
KATNBL1	kznf__ZNF445_Imbeault2017_OM_MEME	ZNF445 (directAnnotation).
KATNBL1	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
KATNBL1	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
KATNBL1	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
KATNBL1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
KATNBL1	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
KATNBL1	hdpi__GTF3C2	GTF3C2 (directAnnotation).
KATNBL1	transfac_pro__M06126	ZNF43 (directAnnotation).
KATNBL1	tfdimers__MD00585	EBF1; STAT1 (directAnnotation).
KATNBL1	metacluster_100.2	ZNF440 (directAnnotation).
KATNBL1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."