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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KAT7

Summary for KAT7

Gene information	Gene symbol	KAT7
	Ensembl ID	ENSG00000136504
	Entrez ID	11143
	Gene name	lysine acetyltransferase 7
	Synonyms	HBO1\|HBOA\|MYST2\|ZC2HC7
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KAT7

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.291839	9.58e-21
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.258125	0.00e+00

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Expression of KAT7 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KAT7

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KAT7

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KAT7	hsa-miR-17-3p	98.9631	NM_001199155
KAT7	hsa-miR-765	97.3207	NM_007067
KAT7	hsa-miR-3919	97.2967	NM_007067
KAT7	hsa-miR-1288-5p	97.0935	NM_007067
KAT7	hsa-miR-148a-3p	96.7611	NM_001199155
KAT7	hsa-miR-152-3p	96.7611	NM_001199155
KAT7	hsa-miR-148b-3p	96.7611	NM_001199155
KAT7	hsa-miR-5190	95.2408	NM_001199155
KAT7	hsa-miR-11181-3p	94.6329	NM_007067
KAT7	hsa-miR-506-3p	94.3014	NM_001199155
KAT7	hsa-miR-124-3p	94.3014	NM_001199155
KAT7	hsa-miR-5683	93.7721	NM_007067
KAT7	hsa-miR-6734-3p	93.3851	NM_001199155
KAT7	hsa-miR-6796-5p	89.7183	NM_007067
KAT7	hsa-miR-491-5p	89.3389	NM_007067
KAT7	hsa-miR-5582-5p	89.0459	NM_001199155
KAT7	hsa-miR-5681a	88.3916	NM_007067
KAT7	hsa-miR-3689d	87.8662	NM_007067
KAT7	hsa-miR-6851-5p	87.8662	NM_007067
KAT7	hsa-miR-3189-3p	87.7948	NM_001199155
KAT7	hsa-miR-4689	87.6397	NM_007067
KAT7	hsa-miR-10394-5p	87.1641	NM_001199155
KAT7	hsa-miR-1205	87.1641	NM_001199155
KAT7	hsa-miR-4784	85.8323	NM_007067
KAT7	hsa-miR-3150b-3p	85.8323	NM_007067
KAT7	hsa-miR-335-5p	85.6412	NM_007067
KAT7	hsa-miR-1184	85.6186	NM_001199155
KAT7	hsa-miR-3158-5p	85.6186	NM_001199155
KAT7	hsa-miR-539-5p	85.0101	NM_007067
KAT7	hsa-miR-6858-5p	84.1796	NM_007067
KAT7	hsa-miR-3681-3p	84.0467	NM_001199155
KAT7	hsa-miR-216a-3p	84.0467	NM_001199155
KAT7	hsa-miR-128-3p	84.0467	NM_001199155
KAT7	hsa-miR-4699-3p	83.308	NM_007067
KAT7	hsa-miR-4738-3p	82.8338	NM_007067
KAT7	hsa-miR-5100	82.6568	NM_007067
KAT7	hsa-miR-5196-5p	81.9776	NM_007067
KAT7	hsa-miR-4747-5p	81.9776	NM_007067
KAT7	hsa-miR-657	81.8676	NM_007067
KAT7	hsa-miR-6866-3p	80.3892	NM_007067
KAT7	hsa-miR-188-5p	80.3892	NM_007067
KAT7	hsa-miR-8485	80.3833	NM_007067
KAT7	hsa-miR-4468	80.2047	NM_007067
KAT7	hsa-miR-3202	80.125	NM_007067

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Motifs and transcription factors (TFs) regulating KAT7

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KAT7	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
KAT7	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
KAT7	metacluster_174.6	NFYA; NFYB; NFYB; NFYC (directAnnotation).
KAT7	jaspar__MA0502.2	NFYB (directAnnotation).
KAT7	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
KAT7	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
KAT7	metacluster_141.2	E2F2; E2F3 (directAnnotation).
KAT7	metacluster_45.6	E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F4; E2F4 (directAnnotation). E2F2; E2F3 (inferredBy_Orthology).
KAT7	taipale__YY2_DBD_NNCCGCCATNW_repr	YY2 (directAnnotation).
KAT7	kznf__ZNF343_Imbeault2017_OM_RCADE	ZNF343 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."