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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KANSL1

Summary for KANSL1

Gene information	Gene symbol	KANSL1
	Ensembl ID	ENSG00000275867
	Entrez ID	284058
	Gene name	KAT8 regulatory NSL complex subunit 1
	Synonyms	CENP-36\|DKFZP727C091\|KIAA1267\|MSL1v1\|NSL1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: KANSL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.34512	1.11e-40
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.282472	1.97e-15

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Expression of KANSL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KANSL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KANSL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KANSL1	hsa-miR-942-3p	96.7333	NM_015443
KANSL1	hsa-miR-1180-3p	95.9823	NM_015443
KANSL1	hsa-miR-365b-3p	95.9482	NM_001193465
KANSL1	hsa-miR-365a-3p	95.9482	NM_001193465
KANSL1	hsa-miR-155-5p	94.7282	NM_001193465
KANSL1	hsa-miR-1305	93.0139	NM_001193465
KANSL1	hsa-miR-4261	92.8311	NM_001193465
KANSL1	hsa-miR-4269	92.69	NM_001193465
KANSL1	hsa-miR-6715b-5p	92.69	NM_001193465
KANSL1	hsa-miR-4503	92.2507	NM_015443
KANSL1	hsa-miR-548s	91.419	NM_015443
KANSL1	hsa-miR-6792-5p	91.2943	NM_001193465
KANSL1	hsa-miR-409-3p	90.8084	NM_015443
KANSL1	hsa-miR-147b-5p	90.4541	NM_001193465
KANSL1	hsa-miR-6165	89.7766	NM_015443
KANSL1	hsa-miR-4802-3p	89.3905	NM_001193465
KANSL1	hsa-miR-892c-5p	89.2367	NM_015443
KANSL1	hsa-miR-491-3p	89.1801	NM_015443
KANSL1	hsa-miR-3121-3p	88.9311	NM_015443
KANSL1	hsa-miR-934	88.7976	NM_015443
KANSL1	hsa-miR-192-3p	87.8218	NM_001193465
KANSL1	hsa-miR-3174	87.4918	NM_015443
KANSL1	hsa-miR-4672	86.9215	NM_001193465
KANSL1	hsa-miR-3926	86.8397	NM_015443
KANSL1	hsa-miR-653-5p	84.7724	NM_001193465
KANSL1	hsa-miR-548g-3p	84.7678	NM_001193465
KANSL1	hsa-miR-6737-3p	83.0552	NM_015443
KANSL1	hsa-miR-7157-3p	83.0552	NM_015443
KANSL1	hsa-miR-548bc	82.9295	NM_001193465
KANSL1	hsa-miR-548az-3p	82.9295	NM_001193465
KANSL1	hsa-miR-548a-3p	82.9295	NM_001193465
KANSL1	hsa-miR-548ar-3p	82.9295	NM_001193465
KANSL1	hsa-miR-548f-3p	82.9295	NM_001193465
KANSL1	hsa-miR-548e-3p	82.9295	NM_001193465
KANSL1	hsa-miR-4668-5p	82.4947	NM_015443
KANSL1	hsa-miR-548x-3p	81.304	NM_001193465
KANSL1	hsa-miR-548aj-3p	81.304	NM_001193465
KANSL1	hsa-miR-2467-3p	81.2158	NM_015443
KANSL1	hsa-miR-12127	81.0057	NM_015443

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Motifs and transcription factors (TFs) regulating KANSL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KANSL1	metacluster_135.11	NR2C2 (directAnnotation).
KANSL1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
KANSL1	tfdimers__MD00038	TFAP2C (directAnnotation).
KANSL1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
KANSL1	metacluster_7.13	ZFX (directAnnotation).
KANSL1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
KANSL1	cisbp__M00968	MTF2 (directAnnotation).
KANSL1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
KANSL1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
KANSL1	cisbp__M00341	PAX6 (directAnnotation).
KANSL1	metacluster_198.3	ZFP64 (directAnnotation).
KANSL1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
KANSL1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
KANSL1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
KANSL1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
KANSL1	cisbp__M00788	ZFY (inferredBy_Orthology).
KANSL1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
KANSL1	metacluster_175.1	ZNF283 (directAnnotation).
KANSL1	hdpi__ZNF304	ZNF304 (directAnnotation).
KANSL1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
KANSL1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
KANSL1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
KANSL1	transfac_pro__M01199	TRIM28 (directAnnotation).
KANSL1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
KANSL1	metacluster_151.2	ZNF23 (directAnnotation).
KANSL1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KANSL1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
KANSL1	transfac_pro__M03806	ZBTB7C (directAnnotation).
KANSL1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
KANSL1	jaspar__MA0748.2	YY2 (directAnnotation).
KANSL1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
KANSL1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
KANSL1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
KANSL1	hdpi__HIP2	UBE2K (directAnnotation).
KANSL1	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
KANSL1	transfac_pro__M02913	SP140 (inferredBy_Orthology).
KANSL1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
KANSL1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
KANSL1	transfac_pro__M02898	SMAD3 (directAnnotation).
KANSL1	metacluster_191.5	SPDEF (inferredBy_Orthology).
KANSL1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
KANSL1	hdpi__TIMELESS	TIMELESS (directAnnotation).
KANSL1	transfac_pro__M04893	TAF1 (directAnnotation).
KANSL1	cisbp__M00249	WT1 (directAnnotation).
KANSL1	metacluster_182.10	ZFX (directAnnotation).
KANSL1	transfac_pro__M00430	E2F1 (directAnnotation).
KANSL1	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
KANSL1	metacluster_66.4	ARNT2; NR0B1; NR0B1; ZSCAN5A; ZSCAN5A (directAnnotation). ARNT2 (inferredBy_Orthology).
KANSL1	transfac_pro__M00938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."