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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: KANK2

Summary for KANK2

Gene information	Gene symbol	KANK2
	Ensembl ID	ENSG00000197256
	Entrez ID	25959
	Gene name	KN motif and ankyrin repeat domains 2
	Synonyms	ANKRD25\|KIAA1518\|MXRA3
	Gene type	protein_coding
	UniProtAcc	Q63ZY3

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Dataset with differentially expressed gene: KANK2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.462012	0.00e+00
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	0.381816	2.42e-16
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.670119	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.266228	2.28e-30
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	0.293403	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.363988	0.00e+00

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Expression of KANK2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to KANK2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating KANK2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
KANK2	hsa-miR-4306	97.1507	NM_001136191
KANK2	hsa-miR-7156-5p	92.8835	NM_001136191
KANK2	hsa-miR-4644	90.9679	NM_001136191
KANK2	hsa-miR-185-5p	90.9679	NM_001136191
KANK2	hsa-miR-4273	90.8864	NM_001136191
KANK2	hsa-miR-4447	90.4821	NM_001136191
KANK2	hsa-miR-4677-5p	89.7802	NM_001136191
KANK2	hsa-miR-22-5p	88.619	NM_001136191
KANK2	hsa-miR-7151-5p	87.3739	NM_001136191
KANK2	hsa-miR-3662	86.7587	NM_001136191
KANK2	hsa-miR-5696	85.4566	NM_001136191
KANK2	hsa-miR-892b	85.2938	NM_001136191
KANK2	hsa-miR-3159	85.1229	NM_001136191
KANK2	hsa-miR-7106-5p	85.0025	NM_001136191
KANK2	hsa-miR-4784	84.041	NM_001136191
KANK2	hsa-miR-6789-3p	83.9126	NM_001136191
KANK2	hsa-miR-548as-3p	82.9281	NM_001136191
KANK2	hsa-miR-4689	82.7306	NM_001136191
KANK2	hsa-miR-200c-3p	82.1534	NM_001136191
KANK2	hsa-miR-429	82.1534	NM_001136191
KANK2	hsa-miR-200b-3p	82.1534	NM_001136191
KANK2	hsa-miR-383-5p	81.9492	NM_001136191
KANK2	hsa-miR-4724-3p	81.3782	NM_001136191
KANK2	hsa-miR-4477a	81.2181	NM_001136191
KANK2	hsa-miR-3150b-3p	81.0863	NM_001136191
KANK2	hsa-miR-3074-3p	80.6181	NM_001136191
KANK2	hsa-miR-5190	80.2079	NM_001136191

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Motifs and transcription factors (TFs) regulating KANK2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
KANK2	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
KANK2	jaspar__MA0079.5	SP1 (directAnnotation).
KANK2	swissregulon__mm__Atf2	ATF2 (inferredBy_Orthology).
KANK2	hocomoco__FOXP1_HUMAN.H11MO.0.A	FOXP1 (directAnnotation).
KANK2	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
KANK2	transfac_pro__M06117	ZNF23 (directAnnotation).
KANK2	swissregulon__hs__EZH2	EZH2 (directAnnotation).
KANK2	transfac_pro__M03580	SMAD2 (directAnnotation).
KANK2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
KANK2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
KANK2	hdpi__FLI1	FLI1 (directAnnotation).
KANK2	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
KANK2	jaspar__MA1708.1	ETV7 (directAnnotation).
KANK2	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
KANK2	transfac_pro__M06249	ZNF616 (directAnnotation).
KANK2	taipale_tf_pairs__HOXB2_ELK1_TAATKRCCGGAAGNN_CAP_repr	ELK1; HOXB2 (directAnnotation).
KANK2	metacluster_27.29	ZNF583 (directAnnotation). ZNF583 (inferredBy_Orthology).
KANK2	taipale_tf_pairs__ELK1_HOXA3_RSCGGTAATKR_CAP_repr	ELK1; HOXA3 (directAnnotation).
KANK2	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
KANK2	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
KANK2	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."