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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: JMY

Summary for JMY

Gene information	Gene symbol	JMY
	Ensembl ID	ENSG00000152409
	Entrez ID	133746
	Gene name	junction mediating and regulatory protein, p53 cofactor
	Synonyms	FLJ37870\|WHAMM2
	Gene type	protein_coding
	UniProtAcc	Q8N9B5

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Dataset with differentially expressed gene: JMY

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-0.424171	2.94e-04
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.485427	4.62e-02
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.335485	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.494825	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.433994	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.332242	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.284966	1.93e-38
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.46875	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.464891	0.00e+00

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Expression of JMY in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to JMY

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating JMY

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JMY	hsa-miR-218-5p	99.5602	NM_152405
JMY	hsa-miR-548aa	98.2699	NM_152405
JMY	hsa-miR-548t-3p	98.2699	NM_152405
JMY	hsa-miR-548ap-3p	98.2699	NM_152405
JMY	hsa-miR-636	98.1553	NM_152405
JMY	hsa-miR-330-3p	97.6406	NM_152405
JMY	hsa-miR-3611	97.2326	NM_152405
JMY	hsa-miR-4282	96.9587	NM_152405
JMY	hsa-miR-524-5p	96.9295	NM_152405
JMY	hsa-miR-335-3p	96.8952	NM_152405
JMY	hsa-miR-548c-3p	96.7798	NM_152405
JMY	hsa-miR-5581-5p	96.7645	NM_152405
JMY	hsa-miR-148b-3p	96.6339	NM_152405
JMY	hsa-miR-148a-3p	96.6339	NM_152405
JMY	hsa-miR-152-3p	96.6339	NM_152405
JMY	hsa-miR-4297	96.5792	NM_152405
JMY	hsa-miR-520d-5p	96.3924	NM_152405
JMY	hsa-miR-501-5p	96.3242	NM_152405
JMY	hsa-miR-32-5p	96.0057	NM_152405
JMY	hsa-miR-92a-3p	96.0057	NM_152405
JMY	hsa-miR-92b-3p	96.0057	NM_152405
JMY	hsa-miR-4276	95.6397	NM_152405
JMY	hsa-miR-367-3p	94.4154	NM_152405
JMY	hsa-miR-363-3p	94.4154	NM_152405
JMY	hsa-miR-548e-5p	93.854	NM_152405
JMY	hsa-miR-1265	93.8283	NM_152405
JMY	hsa-miR-3942-3p	93.5556	NM_152405
JMY	hsa-miR-25-3p	93.2943	NM_152405
JMY	hsa-miR-3978	92.8372	NM_152405
JMY	hsa-miR-5589-3p	92.8197	NM_152405
JMY	hsa-miR-6715b-3p	92.7582	NM_152405
JMY	hsa-miR-5696	91.9587	NM_152405
JMY	hsa-miR-1276	91.4378	NM_152405
JMY	hsa-miR-550a-3p	91.2676	NM_152405
JMY	hsa-miR-10399-5p	90.7579	NM_152405
JMY	hsa-miR-543	90.1218	NM_152405
JMY	hsa-miR-4671-3p	89.8565	NM_152405
JMY	hsa-miR-5582-3p	89.6189	NM_152405
JMY	hsa-miR-3973	89.3869	NM_152405
JMY	hsa-miR-374c-5p	89.2234	NM_152405
JMY	hsa-miR-655-3p	89.2234	NM_152405
JMY	hsa-miR-6504-3p	88.9433	NM_152405
JMY	hsa-miR-4729	88.6853	NM_152405
JMY	hsa-miR-1323	87.5915	NM_152405
JMY	hsa-miR-628-3p	86.9788	NM_152405
JMY	hsa-miR-153-5p	86.9297	NM_152405
JMY	hsa-miR-320a-3p	86.3923	NM_152405
JMY	hsa-miR-320b	86.3923	NM_152405
JMY	hsa-miR-320d	86.3923	NM_152405
JMY	hsa-miR-4429	86.3923	NM_152405

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Motifs and transcription factors (TFs) regulating JMY

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JMY	jaspar__MA1933.1	SREBF2 (directAnnotation).
JMY	transfac_pro__M06035	ZNF749 (directAnnotation).
JMY	transfac_pro__M06692	PRDM10 (directAnnotation).
JMY	tfdimers__MD00110	FOXG1; FOXO1; PITX3 (directAnnotation).
JMY	transfac_public__M00416	ALX1 (directAnnotation).
JMY	transfac_pro__M06959	ZNF425 (directAnnotation).
JMY	swissregulon__hs__ZNF691	ZNF691 (directAnnotation).
JMY	tfdimers__MD00226	ETS2; MYB (directAnnotation).
JMY	kznf__ZNF33A_Najafabadi2015_ChIP-seq	ZNF33A (directAnnotation).
JMY	transfac_pro__M06968	ZNF467 (inferredBy_Orthology).
JMY	tfdimers__MD00175	EP300; GTF2IRD1 (directAnnotation).
JMY	swissregulon__hs__DBP	DBP (directAnnotation).
JMY	taipale_cyt_meth__OLIG2_AACAGCTGTY_eDBD	OLIG2 (directAnnotation).
JMY	taipale_tf_pairs__ELK1_HOXB13_RNCGGAANYNRTWAAN_CAP	ELK1; HOXB13 (directAnnotation).
JMY	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
JMY	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
JMY	transfac_pro__M00430	E2F1 (directAnnotation).
JMY	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
JMY	transfac_pro__M04893	TAF1 (directAnnotation).
JMY	transfac_pro__M01199	TRIM28 (directAnnotation).
JMY	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
JMY	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
JMY	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
JMY	metacluster_191.5	SPDEF (inferredBy_Orthology).
JMY	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
JMY	transfac_pro__M00938	E2F1 (directAnnotation).
JMY	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
JMY	hdpi__RARA	RARA (directAnnotation).
JMY	cisbp__M00968	MTF2 (directAnnotation).
JMY	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
JMY	hdpi__HTATIP2	HTATIP2 (directAnnotation).
JMY	transfac_pro__M04916	TAF1 (directAnnotation).
JMY	jaspar__MA1122.1	TFDP1 (directAnnotation).
JMY	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
JMY	transfac_pro__M07310	SP5 (directAnnotation).
JMY	hdpi__ZNF304	ZNF304 (directAnnotation).
JMY	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
JMY	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
JMY	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
JMY	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
JMY	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
JMY	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
JMY	transfac_pro__M02089	E2F3 (directAnnotation).
JMY	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
JMY	transfac_pro__M04817	ZBTB33 (directAnnotation).
JMY	tfdimers__MD00483	ZBTB14 (directAnnotation).
JMY	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
JMY	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
JMY	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
JMY	taipale_tf_pairs__ETV2_DLX3_RSCGGAANNNNNYAATTA_CAP	DLX3; ETV2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."