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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: JMJD8

Summary for JMJD8

Gene information	Gene symbol	JMJD8
	Ensembl ID	ENSG00000161999
	Entrez ID	339123
	Gene name	jumonji domain containing 8
	Synonyms	C16orf20
	Gene type	protein_coding
	UniProtAcc	Q96S16

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Dataset with differentially expressed gene: JMJD8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.257861	1.64e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.7052	0.00e+00

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Expression of JMJD8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to JMJD8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating JMJD8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JMJD8	hsa-miR-4492	98.2463	NM_001005920
JMJD8	hsa-miR-4498	97.901	NM_001005920
JMJD8	hsa-miR-3921	97.1236	NM_001005920
JMJD8	hsa-miR-4653-5p	97.1236	NM_001005920
JMJD8	hsa-miR-5001-5p	95.9205	NM_001005920
JMJD8	hsa-miR-762	95.9205	NM_001005920
JMJD8	hsa-miR-6804-5p	95.8475	NM_001323922
JMJD8	hsa-miR-513a-5p	93.215	NM_001323922
JMJD8	hsa-miR-6867-5p	92.8381	NM_001005920
JMJD8	hsa-miR-6880-5p	92.4134	NM_001323922
JMJD8	hsa-miR-4476	91.1546	NM_001323922
JMJD8	hsa-miR-6876-5p	91.1546	NM_001323922
JMJD8	hsa-miR-1255b-5p	88.8257	NM_001005920
JMJD8	hsa-miR-1255a	88.8257	NM_001005920
JMJD8	hsa-miR-765	85.6286	NM_001005920
JMJD8	hsa-miR-6793-3p	85.0325	NM_001005920
JMJD8	hsa-miR-6759-5p	82.9904	NM_001323922
JMJD8	hsa-miR-125a-3p	82.9134	NM_001323922

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Motifs and transcription factors (TFs) regulating JMJD8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JMJD8	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
JMJD8	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
JMJD8	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
JMJD8	cisbp__M08198	ELF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."