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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: JAZF1

Summary for JAZF1

Gene information	Gene symbol	JAZF1
	Ensembl ID	ENSG00000153814
	Entrez ID	221895
	Gene name	JAZF zinc finger 1
	Synonyms	DKFZp761K2222\|TIP27\|ZNF802
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: JAZF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.361029	1.07e-09

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Expression of JAZF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to JAZF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating JAZF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JAZF1	hsa-miR-520g-3p	98.9081	NM_175061
JAZF1	hsa-miR-520h	98.9081	NM_175061
JAZF1	hsa-miR-6835-3p	98.4088	NM_175061
JAZF1	hsa-miR-4422	97.6326	NM_175061
JAZF1	hsa-miR-6773-3p	96.4904	NM_175061
JAZF1	hsa-miR-5580-3p	95.964	NM_175061
JAZF1	hsa-let-7c-3p	95.5111	NM_175061
JAZF1	hsa-miR-208b-5p	95.1533	NM_175061
JAZF1	hsa-miR-182-5p	94.8142	NM_175061
JAZF1	hsa-miR-3973	94.699	NM_175061
JAZF1	hsa-miR-9-3p	94.4262	NM_175061
JAZF1	hsa-miR-200a-3p	94.3473	NM_175061
JAZF1	hsa-miR-141-3p	94.3473	NM_175061
JAZF1	hsa-miR-208a-5p	93.9774	NM_175061
JAZF1	hsa-miR-8063	93.2304	NM_175061
JAZF1	hsa-miR-4710	93.1173	NM_175061
JAZF1	hsa-miR-516a-3p	92.9765	NM_175061
JAZF1	hsa-miR-7162-5p	92.9765	NM_175061
JAZF1	hsa-miR-516b-3p	92.9765	NM_175061
JAZF1	hsa-miR-4506	92.8792	NM_175061
JAZF1	hsa-miR-5682	92.6079	NM_175061
JAZF1	hsa-miR-1283	92.3518	NM_175061
JAZF1	hsa-miR-625-5p	92.0176	NM_175061
JAZF1	hsa-miR-3121-3p	91.7084	NM_175061
JAZF1	hsa-miR-885-5p	91.3784	NM_175061
JAZF1	hsa-miR-10399-5p	91.0367	NM_175061
JAZF1	hsa-miR-6504-3p	91.0367	NM_175061
JAZF1	hsa-miR-12128	90.7834	NM_175061
JAZF1	hsa-miR-618	90.7823	NM_175061
JAZF1	hsa-miR-200c-3p	90.7128	NM_175061
JAZF1	hsa-miR-429	90.7128	NM_175061
JAZF1	hsa-miR-200b-3p	90.7128	NM_175061
JAZF1	hsa-miR-1275	90.6479	NM_175061
JAZF1	hsa-miR-302e	90.4782	NM_175061
JAZF1	hsa-miR-2115-5p	90.4285	NM_175061
JAZF1	hsa-miR-6831-5p	90.1478	NM_175061
JAZF1	hsa-miR-646	90.1463	NM_175061
JAZF1	hsa-miR-4729	90.0321	NM_175061
JAZF1	hsa-miR-520b-5p	89.8942	NM_175061
JAZF1	hsa-miR-519a-2-5p	89.8942	NM_175061
JAZF1	hsa-miR-520f-3p	89.6469	NM_175061
JAZF1	hsa-miR-4705	89.5534	NM_175061
JAZF1	hsa-miR-541-5p	89.1317	NM_175061
JAZF1	hsa-miR-302c-3p	88.9748	NM_175061
JAZF1	hsa-miR-520b-3p	88.9748	NM_175061
JAZF1	hsa-miR-372-3p	88.9748	NM_175061
JAZF1	hsa-miR-302b-3p	88.9748	NM_175061
JAZF1	hsa-miR-520d-3p	88.9748	NM_175061
JAZF1	hsa-miR-373-3p	88.9748	NM_175061
JAZF1	hsa-miR-302d-3p	88.9748	NM_175061

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Motifs and transcription factors (TFs) regulating JAZF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JAZF1	kznf__ZNF282_Isakova2017_SMiLE-seq	ZNF282 (directAnnotation).
JAZF1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
JAZF1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
JAZF1	taipale_tf_pairs__GCM2_HES7_RTRNKGGTNNNGCACGYGNN_CAP_repr	GCM2; HES7 (directAnnotation).
JAZF1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
JAZF1	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
JAZF1	jaspar__MA1122.1	TFDP1 (directAnnotation).
JAZF1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
JAZF1	taipale_tf_pairs__E2F3_TBX21_NGGTGTGNNNGGCGCSN_CAP_repr	E2F3; TBX21 (directAnnotation).
JAZF1	taipale_tf_pairs__GCM1_FIGLA_CASSTGNNNNNNNNNNTGCGGG_CAP_repr	FIGLA; GCM1 (directAnnotation).
JAZF1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
JAZF1	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
JAZF1	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
JAZF1	transfac_pro__M01175	ZBTB7B (directAnnotation).
JAZF1	taipale_tf_pairs__ETV5_TCF3_RNCGGAAGNNNNNCASSTGN_CAP_repr	ETV5; TCF3 (directAnnotation).
JAZF1	metacluster_181.1	EGR2; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI1; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLIS1; ZBTB7A; ZBTB7A; ZBTB7B; ZBTB7B; ZBTB7B; ZBTB7C; ZFP2; ZIC1; ZIC1; ZIC1; ZIC2; ZIC2; ZIC3; ZNF449; ZNF71 (directAnnotation). GLI1; GLI1; GLI2; GLI2; GLI2; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; GLI3; VPS72; ZIC3; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
JAZF1	metacluster_3.14	WT1; WT1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."