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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: JAG1

Summary for JAG1

Gene information	Gene symbol	JAG1
	Ensembl ID	ENSG00000101384
	Entrez ID	182
	Gene name	jagged canonical Notch ligand 1
	Synonyms	AGS\|AHD\|AWS\|CD339\|HJ1\|JAGL1
	Gene type	protein_coding
	UniProtAcc	P78504

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Dataset with differentially expressed gene: JAG1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.341254	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.59088	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.48994	2.03e-18

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Expression of JAG1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to JAG1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
JAG1	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating JAG1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
JAG1	hsa-miR-3613-3p	99.7337	NM_000214
JAG1	hsa-miR-5692a	99.5517	NM_000214
JAG1	hsa-miR-377-3p	97.7422	NM_000214
JAG1	hsa-miR-5003-3p	97.1614	NM_000214
JAG1	hsa-miR-203a-5p	96.3258	NM_000214
JAG1	hsa-miR-551b-5p	96.0627	NM_000214
JAG1	hsa-miR-16-1-3p	95.7692	NM_000214
JAG1	hsa-miR-1297	95.6875	NM_000214
JAG1	hsa-miR-4272	94.9139	NM_000214
JAG1	hsa-miR-4762-5p	94.682	NM_000214
JAG1	hsa-miR-26a-5p	94.5937	NM_000214
JAG1	hsa-miR-26b-5p	94.5937	NM_000214
JAG1	hsa-miR-141-3p	94.3767	NM_000214
JAG1	hsa-miR-200a-3p	94.3767	NM_000214
JAG1	hsa-miR-520d-5p	94.0739	NM_000214
JAG1	hsa-miR-524-5p	94.0739	NM_000214
JAG1	hsa-miR-376a-2-5p	93.9183	NM_000214
JAG1	hsa-miR-4465	93.5031	NM_000214
JAG1	hsa-miR-539-3p	92.5606	NM_000214
JAG1	hsa-miR-4477a	92.426	NM_000214
JAG1	hsa-miR-3654	92.1915	NM_000214
JAG1	hsa-miR-6854-5p	92.0047	NM_000214
JAG1	hsa-miR-936	91.9249	NM_000214
JAG1	hsa-miR-548t-3p	91.7783	NM_000214
JAG1	hsa-miR-548aa	91.7783	NM_000214
JAG1	hsa-miR-548ap-3p	91.7783	NM_000214
JAG1	hsa-miR-485-3p	90.8063	NM_000214
JAG1	hsa-miR-196a-3p	90.6008	NM_000214
JAG1	hsa-miR-21-5p	90.5403	NM_000214
JAG1	hsa-miR-489-3p	90.2811	NM_000214
JAG1	hsa-miR-6868-5p	90.0239	NM_000214
JAG1	hsa-miR-153-3p	89.7242	NM_000214
JAG1	hsa-miR-98-3p	89.5016	NM_000214
JAG1	hsa-let-7a-3p	89.5016	NM_000214
JAG1	hsa-let-7b-3p	89.5016	NM_000214
JAG1	hsa-miR-5579-3p	89.2644	NM_000214
JAG1	hsa-miR-3145-3p	89.0896	NM_000214
JAG1	hsa-miR-3680-3p	89.0333	NM_000214
JAG1	hsa-miR-95-5p	88.8913	NM_000214
JAG1	hsa-miR-124-3p	88.8279	NM_000214
JAG1	hsa-miR-506-3p	88.8279	NM_000214
JAG1	hsa-miR-140-5p	88.6414	NM_000214
JAG1	hsa-miR-607	88.5998	NM_000214
JAG1	hsa-miR-4666a-3p	87.9833	NM_000214
JAG1	hsa-miR-590-5p	87.9253	NM_000214
JAG1	hsa-let-7f-1-3p	87.6957	NM_000214
JAG1	hsa-miR-7109-3p	87.4857	NM_000214
JAG1	hsa-miR-34a-5p	87.2877	NM_000214
JAG1	hsa-miR-34c-5p	87.2877	NM_000214
JAG1	hsa-miR-449a	87.2877	NM_000214

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Motifs and transcription factors (TFs) regulating JAG1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
JAG1	transfac_pro__M06213	ZNF267 (directAnnotation).
JAG1	transfac_pro__M06035	ZNF749 (directAnnotation).
JAG1	kznf__ZNF282_Imbeault2017_OM_RCADE	ZNF282 (directAnnotation).
JAG1	transfac_pro__M05788	ZNF569 (inferredBy_Orthology).
JAG1	metacluster_52.11	ZNF184 (directAnnotation).
JAG1	transfac_pro__M07436	WT1 (directAnnotation).
JAG1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
JAG1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
JAG1	hdpi__TFAM	TFAM (directAnnotation).
JAG1	transfac_pro__M02089	E2F3 (directAnnotation).
JAG1	transfac_pro__M07329	SP7 (directAnnotation).
JAG1	transfac_pro__M01122	ZNF219 (directAnnotation).
JAG1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
JAG1	metacluster_44.7	NKX3-2 (directAnnotation).
JAG1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
JAG1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
JAG1	transfac_pro__M08819	KLF2 (directAnnotation).
JAG1	transfac_public__M00415	ZEB1 (directAnnotation).
JAG1	transfac_pro__M01175	ZBTB7B (directAnnotation).
JAG1	cisbp__M00249	WT1 (directAnnotation).
JAG1	transfac_pro__M01118	WT1 (directAnnotation).
JAG1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
JAG1	transfac_pro__M01303	SP1 (directAnnotation).
JAG1	transfac_pro__M04595	SALL2 (directAnnotation).
JAG1	transfac_pro__M01837	KLF11 (directAnnotation).
JAG1	transfac_pro__M00716	ZBTB14 (directAnnotation).
JAG1	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
JAG1	transfac_pro__M07397	ZNF148 (directAnnotation).
JAG1	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
JAG1	transfac_pro__M01104	OVOL2 (directAnnotation).
JAG1	transfac_pro__M00986	CHURC1 (directAnnotation).
JAG1	metacluster_135.11	NR2C2 (directAnnotation).
JAG1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
JAG1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
JAG1	metacluster_7.13	ZFX (directAnnotation).
JAG1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
JAG1	cisbp__M00968	MTF2 (directAnnotation).
JAG1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
JAG1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
JAG1	cisbp__M00341	PAX6 (directAnnotation).
JAG1	metacluster_198.3	ZFP64 (directAnnotation).
JAG1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
JAG1	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
JAG1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
JAG1	cisbp__M00788	ZFY (inferredBy_Orthology).
JAG1	metacluster_175.1	ZNF283 (directAnnotation).
JAG1	hdpi__ZNF304	ZNF304 (directAnnotation).
JAG1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
JAG1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
JAG1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."