Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IVNS1ABP

Summary for IVNS1ABP

Gene information	Gene symbol	IVNS1ABP
	Ensembl ID	ENSG00000116679
	Entrez ID	10625
	Gene name	influenza virus NS1A binding protein
	Synonyms	ARA3\|HSPC068\|KIAA0850\|KLHL39\|ND1\|NS-1\|NS1-BP
	Gene type	protein_coding
	UniProtAcc	Q9Y6Y0

Top

Dataset with differentially expressed gene: IVNS1ABP

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.474742	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.272335	2.40e-05
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD8+ T cells	-0.573888	0.00e+00
PMID34715028	patients	Tumor tissue	Kidney cancer	Clear cell renal cell carcinoma (ccRCC)	Immunotherapy	nivolumab	post	CD4+ T cells	-0.606745	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Mono/Macro	-0.433907	0.00e+00
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.281416	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.357591	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.496158	0.00e+00

Top

Expression of IVNS1ABP in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to IVNS1ABP

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating IVNS1ABP

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IVNS1ABP	hsa-miR-12136	99.3855	NM_006469
IVNS1ABP	hsa-miR-145-5p	97.1682	NM_006469
IVNS1ABP	hsa-miR-5195-3p	97.1682	NM_006469
IVNS1ABP	hsa-miR-874-5p	94.3406	NM_006469
IVNS1ABP	hsa-miR-3942-3p	91.5361	NM_006469
IVNS1ABP	hsa-miR-19b-3p	91.1342	NM_006469
IVNS1ABP	hsa-miR-19a-3p	91.1342	NM_006469
IVNS1ABP	hsa-miR-548an	90.2812	NM_006469
IVNS1ABP	hsa-miR-548n	90.1427	NM_006469
IVNS1ABP	hsa-miR-513b-5p	90.0156	NM_006469
IVNS1ABP	hsa-miR-548x-5p	89.9095	NM_006469
IVNS1ABP	hsa-miR-548g-5p	89.9095	NM_006469
IVNS1ABP	hsa-miR-548aj-5p	89.9095	NM_006469
IVNS1ABP	hsa-miR-548f-5p	89.9095	NM_006469
IVNS1ABP	hsa-miR-205-3p	89.734	NM_006469
IVNS1ABP	hsa-miR-372-5p	89.3959	NM_006469
IVNS1ABP	hsa-miR-194-5p	89.0327	NM_006469
IVNS1ABP	hsa-miR-328-3p	88.3103	NM_006469
IVNS1ABP	hsa-miR-16-5p	87.8958	NM_006469
IVNS1ABP	hsa-miR-195-5p	87.8958	NM_006469
IVNS1ABP	hsa-miR-15b-5p	87.3301	NM_006469
IVNS1ABP	hsa-miR-6838-5p	87.3301	NM_006469
IVNS1ABP	hsa-miR-15a-5p	87.3301	NM_006469
IVNS1ABP	hsa-miR-548k	87.1658	NM_006469
IVNS1ABP	hsa-miR-548av-5p	87.1658	NM_006469
IVNS1ABP	hsa-miR-8054	87.1658	NM_006469
IVNS1ABP	hsa-miR-499a-3p	87.1005	NM_006469
IVNS1ABP	hsa-miR-499b-3p	87.1005	NM_006469
IVNS1ABP	hsa-miR-424-5p	87.0889	NM_006469
IVNS1ABP	hsa-miR-497-5p	87.0889	NM_006469
IVNS1ABP	hsa-miR-7703	86.7448	NM_006469
IVNS1ABP	hsa-miR-3671	86.6955	NM_006469
IVNS1ABP	hsa-miR-548at-5p	85.5793	NM_006469
IVNS1ABP	hsa-miR-559	84.5026	NM_006469
IVNS1ABP	hsa-miR-633	83.4575	NM_006469
IVNS1ABP	hsa-miR-148b-5p	82.8884	NM_006469
IVNS1ABP	hsa-miR-6874-3p	82.8884	NM_006469
IVNS1ABP	hsa-miR-4677-3p	82.1466	NM_006469
IVNS1ABP	hsa-miR-548o-3p	81.9449	NM_006469
IVNS1ABP	hsa-miR-1323	81.5632	NM_006469
IVNS1ABP	hsa-miR-3169	81.1105	NM_006469
IVNS1ABP	hsa-miR-6834-5p	80.3729	NM_006469

Page: 1

Top

Motifs and transcription factors (TFs) regulating IVNS1ABP

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IVNS1ABP	metacluster_7.13	ZFX (directAnnotation).
IVNS1ABP	cisbp__M01863	ZNF711 (inferredBy_Orthology).
IVNS1ABP	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
IVNS1ABP	metacluster_151.2	ZNF23 (directAnnotation).
IVNS1ABP	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
IVNS1ABP	transfac_pro__M05479	ZNF580 (directAnnotation).
IVNS1ABP	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
IVNS1ABP	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
IVNS1ABP	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
IVNS1ABP	metacluster_182.10	ZFX (directAnnotation).
IVNS1ABP	hdpi__ETV4	ETV4 (directAnnotation).
IVNS1ABP	jaspar__MA0748.2	YY2 (directAnnotation).
IVNS1ABP	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
IVNS1ABP	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
IVNS1ABP	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
IVNS1ABP	jaspar__MA0079.5	SP1 (directAnnotation).
IVNS1ABP	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
IVNS1ABP	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
IVNS1ABP	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
IVNS1ABP	transfac_pro__M07397	ZNF148 (directAnnotation).
IVNS1ABP	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
IVNS1ABP	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
IVNS1ABP	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
IVNS1ABP	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
IVNS1ABP	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
IVNS1ABP	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
IVNS1ABP	transfac_pro__M01175	ZBTB7B (directAnnotation).
IVNS1ABP	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
IVNS1ABP	tfdimers__MD00151	CHURC1 (directAnnotation).
IVNS1ABP	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
IVNS1ABP	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
IVNS1ABP	transfac_pro__M01303	SP1 (directAnnotation).
IVNS1ABP	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
IVNS1ABP	swissregulon__hs__CHD1	CHD1 (directAnnotation).
IVNS1ABP	transfac_pro__M02090	E2F4 (directAnnotation).
IVNS1ABP	transfac_pro__M01714	KLF15 (directAnnotation).
IVNS1ABP	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
IVNS1ABP	jaspar__MA1122.1	TFDP1 (directAnnotation).
IVNS1ABP	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
IVNS1ABP	transfac_pro__M02089	E2F3 (directAnnotation).
IVNS1ABP	transfac_pro__M12604	ZNF444 (directAnnotation).
IVNS1ABP	metacluster_3.14	WT1; WT1 (directAnnotation).
IVNS1ABP	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
IVNS1ABP	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
IVNS1ABP	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
IVNS1ABP	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
IVNS1ABP	cisbp__M07938	E2F1 (directAnnotation).
IVNS1ABP	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
IVNS1ABP	transfac_pro__M07436	WT1 (directAnnotation).
IVNS1ABP	transfac_pro__M02281	SP1 (directAnnotation).

Page: 1 2 3 4

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."