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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ITPKB

Summary for ITPKB

Gene information	Gene symbol	ITPKB
	Ensembl ID	ENSG00000143772
	Entrez ID	3707
	Gene name	inositol-trisphosphate 3-kinase B
	Synonyms	IP3-3KB\|IP3KB
	Gene type	protein_coding
	UniProtAcc	P27987

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Dataset with differentially expressed gene: ITPKB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.271423	0.00e+00

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Expression of ITPKB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ITPKB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ITPKB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ITPKB	hsa-miR-506-5p	93.0733	NM_002221
ITPKB	hsa-miR-1283	89.9991	NM_002221
ITPKB	hsa-miR-194-5p	89.6341	NM_002221
ITPKB	hsa-miR-3117-5p	86.982	NM_002221
ITPKB	hsa-miR-4651	86.1709	NM_002221
ITPKB	hsa-miR-608	86.1484	NM_002221
ITPKB	hsa-miR-410-3p	84.9928	NM_002221
ITPKB	hsa-miR-6809-3p	84.7978	NM_002221
ITPKB	hsa-miR-142-3p	84.4789	NM_002221
ITPKB	hsa-miR-6722-3p	84.2865	NM_002221
ITPKB	hsa-miR-6739-3p	83.7082	NM_002221
ITPKB	hsa-miR-4664-5p	82.9736	NM_002221
ITPKB	hsa-miR-519e-5p	82.6218	NM_002221
ITPKB	hsa-miR-515-5p	82.6218	NM_002221
ITPKB	hsa-miR-1258	82.5171	NM_002221
ITPKB	hsa-miR-1909-3p	81.4892	NM_002221
ITPKB	hsa-miR-6073	81.4255	NM_002221
ITPKB	hsa-miR-6779-3p	81.1581	NM_002221
ITPKB	hsa-miR-342-5p	80.8762	NM_002221
ITPKB	hsa-miR-519a-2-5p	80.4382	NM_002221
ITPKB	hsa-miR-520b-5p	80.4382	NM_002221
ITPKB	hsa-miR-5008-5p	80.4024	NM_002221

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Motifs and transcription factors (TFs) regulating ITPKB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ITPKB	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ITPKB	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ITPKB	transfac_pro__M04893	TAF1 (directAnnotation).
ITPKB	transfac_pro__M01199	TRIM28 (directAnnotation).
ITPKB	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ITPKB	hdpi__HIP2	UBE2K (directAnnotation).
ITPKB	transfac_pro__M00938	E2F1 (directAnnotation).
ITPKB	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
ITPKB	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ITPKB	transfac_pro__M04916	TAF1 (directAnnotation).
ITPKB	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
ITPKB	transfac_pro__M07310	SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."