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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ITGBL1

Summary for ITGBL1

Gene information	Gene symbol	ITGBL1
	Ensembl ID	ENSG00000198542
	Entrez ID	9358
	Gene name	integrin subunit beta like 1
	Synonyms	OSCP\|TIED
	Gene type	protein_coding
	UniProtAcc	O95965

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Dataset with differentially expressed gene: ITGBL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.404389	0.00e+00

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Expression of ITGBL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ITGBL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ITGBL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ITGBL1	hsa-miR-8485	99.9843	NM_001271754
ITGBL1	hsa-miR-664b-3p	97.1681	NM_001271754
ITGBL1	hsa-miR-579-3p	97.1681	NM_001271754
ITGBL1	hsa-miR-4659a-3p	96.591	NM_001271754
ITGBL1	hsa-miR-4659b-3p	96.591	NM_001271754
ITGBL1	hsa-miR-576-5p	96.3435	NM_004791
ITGBL1	hsa-miR-3123	95.5943	NM_001271754
ITGBL1	hsa-miR-4495	93.9904	NM_001271754
ITGBL1	hsa-miR-558	93.9666	NM_001271754
ITGBL1	hsa-miR-411-3p	93.0804	NM_001271754
ITGBL1	hsa-miR-379-3p	93.0804	NM_001271754
ITGBL1	hsa-miR-2053	92.2503	NM_001271754
ITGBL1	hsa-miR-3148	92.2308	NM_004791
ITGBL1	hsa-miR-29b-2-5p	91.7652	NM_001271754
ITGBL1	hsa-miR-889-3p	91.3143	NM_001271754
ITGBL1	hsa-miR-3976	90.8818	NM_001271754
ITGBL1	hsa-miR-4288	90.636	NM_004791
ITGBL1	hsa-miR-3680-3p	89.6614	NM_001271754
ITGBL1	hsa-miR-5689	89.1845	NM_001271754
ITGBL1	hsa-miR-335-3p	89.0625	NM_004791
ITGBL1	hsa-miR-493-5p	88.4559	NM_004791
ITGBL1	hsa-miR-5010-3p	88.0575	NM_001271754
ITGBL1	hsa-miR-7855-5p	87.9454	NM_004791
ITGBL1	hsa-miR-6869-5p	87.4312	NM_001271754
ITGBL1	hsa-miR-6857-3p	87.4308	NM_001271754
ITGBL1	hsa-miR-5688	86.1544	NM_001271754
ITGBL1	hsa-miR-153-5p	86.1422	NM_001271754
ITGBL1	hsa-miR-495-3p	85.6943	NM_001271754
ITGBL1	hsa-miR-511-5p	85.422	NM_001271754
ITGBL1	hsa-miR-3925-5p	85.3817	NM_001271754
ITGBL1	hsa-miR-3163	84.4456	NM_001271754
ITGBL1	hsa-miR-6745	84.1043	NM_004791
ITGBL1	hsa-miR-4263	83.8597	NM_004791
ITGBL1	hsa-miR-4703-3p	83.4329	NM_001271754
ITGBL1	hsa-miR-632	82.8694	NM_004791
ITGBL1	hsa-miR-3924	82.6273	NM_001271754
ITGBL1	hsa-miR-876-5p	82.2811	NM_004791
ITGBL1	hsa-miR-363-5p	82.1964	NM_004791
ITGBL1	hsa-miR-9-5p	82.1323	NM_004791
ITGBL1	hsa-miR-581	81.9471	NM_004791
ITGBL1	hsa-miR-1276	81.7994	NM_001271754
ITGBL1	hsa-miR-5696	81.4869	NM_001271754
ITGBL1	hsa-miR-3167	81.2773	NM_004791
ITGBL1	hsa-miR-8066	81.0242	NM_004791
ITGBL1	hsa-miR-145-3p	81.0016	NM_001271754
ITGBL1	hsa-miR-1231	80.2237	NM_004791

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Motifs and transcription factors (TFs) regulating ITGBL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ITGBL1	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
ITGBL1	jaspar__MA1483.2	ELF2 (directAnnotation).
ITGBL1	transfac_pro__M04826	EP300 (directAnnotation).
ITGBL1	hdpi__ETV4	ETV4 (directAnnotation).
ITGBL1	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ITGBL1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."