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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ITGB8

Summary for ITGB8

Gene information	Gene symbol	ITGB8
	Ensembl ID	ENSG00000105855
	Entrez ID	3696
	Gene name	integrin subunit beta 8
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P26012

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Dataset with differentially expressed gene: ITGB8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.35257	9.34e-21

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Expression of ITGB8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ITGB8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
ITGB8	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating ITGB8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ITGB8	hsa-miR-548ah-5p	99.2655	NM_002214
ITGB8	hsa-miR-3671	99.2409	NM_002214
ITGB8	hsa-miR-106b-5p	99.2002	NM_002214
ITGB8	hsa-miR-20a-5p	99.2002	NM_002214
ITGB8	hsa-miR-4282	99.1927	NM_002214
ITGB8	hsa-miR-3609	99.0584	NM_002214
ITGB8	hsa-miR-20b-5p	98.7293	NM_002214
ITGB8	hsa-miR-17-5p	98.7293	NM_002214
ITGB8	hsa-miR-106a-5p	98.7293	NM_002214
ITGB8	hsa-miR-208b-5p	98.5464	NM_002214
ITGB8	hsa-miR-208a-5p	98.4852	NM_002214
ITGB8	hsa-miR-93-5p	98.1812	NM_002214
ITGB8	hsa-miR-519d-3p	98.1812	NM_002214
ITGB8	hsa-miR-526b-3p	98.1282	NM_002214
ITGB8	hsa-miR-590-3p	98.1255	NM_002214
ITGB8	hsa-miR-5195-3p	97.9513	NM_002214
ITGB8	hsa-miR-145-5p	97.9513	NM_002214
ITGB8	hsa-miR-205-3p	97.1569	NM_002214
ITGB8	hsa-miR-19b-3p	97.0654	NM_002214
ITGB8	hsa-miR-19a-3p	97.0654	NM_002214
ITGB8	hsa-miR-32-3p	96.3838	NM_002214
ITGB8	hsa-miR-142-3p	96.1057	NM_002214
ITGB8	hsa-miR-4796-3p	95.8219	NM_002214
ITGB8	hsa-miR-3682-3p	95.7014	NM_002214
ITGB8	hsa-miR-1297	95.5962	NM_002214
ITGB8	hsa-miR-548c-3p	95.5693	NM_002214
ITGB8	hsa-miR-199a-3p	95.4227	NM_002214
ITGB8	hsa-miR-199b-3p	95.4227	NM_002214
ITGB8	hsa-miR-570-3p	95.0283	NM_002214
ITGB8	hsa-miR-607	94.7667	NM_002214
ITGB8	hsa-miR-573	94.3891	NM_002214
ITGB8	hsa-miR-3616-5p	94.316	NM_002214
ITGB8	hsa-miR-3163	94.3064	NM_002214
ITGB8	hsa-miR-4495	94.1757	NM_002214
ITGB8	hsa-miR-335-3p	94.0627	NM_002214
ITGB8	hsa-miR-454-3p	93.6058	NM_002214
ITGB8	hsa-miR-1279	93.5684	NM_002214
ITGB8	hsa-miR-4272	93.2697	NM_002214
ITGB8	hsa-miR-5692a	93.2288	NM_002214
ITGB8	hsa-miR-3129-5p	93.1239	NM_002214
ITGB8	hsa-miR-4276	93.076	NM_002214
ITGB8	hsa-miR-5579-3p	92.9758	NM_002214
ITGB8	hsa-miR-3658	92.9329	NM_002214
ITGB8	hsa-miR-130a-3p	92.412	NM_002214
ITGB8	hsa-miR-4295	92.412	NM_002214
ITGB8	hsa-miR-301a-3p	92.412	NM_002214
ITGB8	hsa-miR-130b-3p	92.412	NM_002214
ITGB8	hsa-miR-301b-3p	92.412	NM_002214
ITGB8	hsa-miR-3666	92.412	NM_002214
ITGB8	hsa-miR-26a-5p	92.3877	NM_002214

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Motifs and transcription factors (TFs) regulating ITGB8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ITGB8	taipale_tf_pairs__GCM2_ELK1_NNRNGGGCGGAARTN_CAP	ELK1; GCM2 (directAnnotation).
ITGB8	hdpi__MYEF2	MYEF2 (directAnnotation).
ITGB8	metacluster_131.6	EGR2; EGR4 (directAnnotation). EGR2; EGR3 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."