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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target

Gene: ITGB1

Summary for ITGB1

Gene informationGene symbol

ITGB1

Ensembl ID

ENSG00000150093

Entrez ID

3688

Gene nameintegrin subunit beta 1
SynonymsCD29|FNRB|GPIIA|MDF2|MSK12
Gene typeprotein_coding
UniProtAcc

NA


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Dataset with differentially expressed gene: ITGB1

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE140440

DU145 and PC cell linesCell lineProstate cancerProstate cancerChemotherapydocetaxelNAMalignant cells-0.9107599.25e-06

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-0.5406220.00e+00

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells0.2672471.51e-23

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells0.3786998.16e-43

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreB cells0.3560392.55e-13

GSE169246_PacTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpreCD4+ T cells0.424050.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreB cells0.3854055.97e-37

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreCD4+ T cells0.3458430.00e+00

GSE169246_PacAteTissue

patientsTumor tissueBreast cancerAdvanced triple-negative breast cancer (TNBC)Immunotherapyatezolizumab + paclitaxelpreNK cells0.2588999.94e-26

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preCD8+ T cells0.3406420.00e+00

GSE197268_Axi-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapyaxi-cel (CAR-T)preNK cells0.3783390.00e+00

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNACD4+ T cells-0.3228121.03e-04

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAErythrocytes-0.3918174.74e-20

GSE164551

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)ImmunotherapyCAR-TNAMono/Macro-0.7691720.00e+00

PMID34715028

patientsTumor tissueKidney cancerClear cell renal cell carcinoma (ccRCC)ImmunotherapynivolumabpostCD4+ T cells-0.4935557.66e-37

GSE207422_Sin

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapysintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postCD8+ T cells0.4250457.62e-21

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD4+ T cells0.3099377.88e-28

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preNK cells0.4498781.10e-31

GSE197268_Tisa-cel

patientsPeripheral blood mononuclear cellsAcute lymphoblastic leukemiaLarge B-cell acute lymphoblastic leukemia (B-ALL)Immunotherapytisa-cel (CAR-T)preCD8+ T cells0.3617090.00e+00

GSE207422_Tor

patientsTumor tissueLung cancerEGFR/ALK mutation negative non-small cell lung cancer (NSCLC)Immunotherapytoripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)postMalignant cells0.5721611.34e-24

GSE189460

patientsBone marrow aspirateMultiple myelomaMultiple myeloma (MM)Targeted therapybortezomib + melphalan + prednisolonepreMalignant cells0.3040.00e+00

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreCD8+ T cells-0.3545151.82e-44

GSE168668

LNCaP cell lineCell lineProstate cancerProstate cancerTargeted therapyenzalutamideNAMalignant cells-0.2653670.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells-0.470230.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostNK cells0.6243530.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostCD4+ T cells0.8147860.00e+00

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpostCD8+ T cells0.4872886.93e-10

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreCD8+ T cells0.568023.17e-28

GSE111014

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaChronic lymphocytic leukemia (CLL)Targeted therapyibrutinibpreMalignant cells0.581990.00e+00

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells0.4271774.81e-29

GSE131984_Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapypalbociclibNAMalignant cells0.3190864.06e-10

GSE108397

451Lu cell lineCell lineMelanomaMelanomaTargeted therapyPLX-4720NAMalignant cells-0.4985380.00e+00

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostCD8+ T cells-0.3140124.83e-36

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostNK cells-0.3003462.40e-03

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostCD4+ T cells-0.5442853.57e-06

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells-0.3249710.00e+00

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Expression of ITGB1 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ITGB1

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.
Gene symbolMechanism

ITGB1

Unusual Activation of Pro-survival Pathway
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MicroRNAs (miRNA) regulating ITGB1

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ITGB1hsa-miR-9-3p99.793NM_033668
ITGB1hsa-miR-124-3p99.7814NM_033668
ITGB1hsa-miR-506-3p99.7814NM_033668
ITGB1hsa-miR-5692a99.7301NM_033668
ITGB1hsa-miR-548an99.5738NM_033668
ITGB1hsa-miR-320c97.443NM_033668
ITGB1hsa-miR-320b97.443NM_033668
ITGB1hsa-miR-442997.443NM_033668
ITGB1hsa-miR-320d97.443NM_033668
ITGB1hsa-miR-320a-3p97.443NM_033668
ITGB1hsa-miR-1213697.3638NM_033668
ITGB1hsa-miR-548c-3p97.358NM_133376
ITGB1hsa-miR-183-5p96.8435NM_033668
ITGB1hsa-miR-374b-3p94.1084NM_033668
ITGB1hsa-miR-60794.0047NM_033668
ITGB1hsa-miR-493-5p93.9728NM_033668
ITGB1hsa-miR-7-1-3p90.6177NM_033668
ITGB1hsa-miR-7-2-3p90.6177NM_033668
ITGB1hsa-miR-127988.9232NM_033668
ITGB1hsa-miR-3157-3p88.4527NM_033668
ITGB1hsa-miR-130588.1045NM_133376
ITGB1hsa-miR-655-3p87.7729NM_033668
ITGB1hsa-miR-316487.3446NM_033668
ITGB1hsa-miR-311886.7465NM_033668
ITGB1hsa-miR-5582-5p86.65NM_033668
ITGB1hsa-miR-6853-3p86.4801NM_133376
ITGB1hsa-miR-430886.2079NM_033668
ITGB1hsa-miR-5197-5p86.1425NM_033668
ITGB1hsa-miR-888-3p86.1125NM_033668
ITGB1hsa-miR-548t-5p85.9882NM_033668
ITGB1hsa-miR-548az-5p85.9882NM_033668
ITGB1hsa-miR-374c-5p85.1477NM_033668
ITGB1hsa-miR-6830-3p84.7738NM_133376
ITGB1hsa-miR-18b-3p84.31NM_033668
ITGB1hsa-miR-134-5p84.2983NM_033668
ITGB1hsa-miR-6820-3p84.2983NM_033668
ITGB1hsa-miR-429284.2804NM_033668
ITGB1hsa-miR-6791-5p84.2804NM_033668
ITGB1hsa-let-7c-3p83.8645NM_033668
ITGB1hsa-let-7g-3p83.8645NM_033668
ITGB1hsa-let-7a-2-3p83.8645NM_033668
ITGB1hsa-miR-548ah-5p83.3447NM_133376
ITGB1hsa-miR-360983.3447NM_133376
ITGB1hsa-miR-6735-3p83.0606NM_133376
ITGB1hsa-miR-4755-5p81.998NM_033668
ITGB1hsa-miR-5006-3p81.998NM_033668
ITGB1hsa-miR-449580.3074NM_133376
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Motifs and transcription factors (TFs) regulating ITGB1

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ITGB1metacluster_7.13ZFX (directAnnotation).
ITGB1cisbp__M01863ZNF711 (inferredBy_Orthology).
ITGB1taipale_tf_pairs__ETS2_RCCGGAAGTG_HTETS2 (directAnnotation).
ITGB1transfac_pro__M05578ZFP92 (inferredBy_Orthology).
ITGB1taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methZNF385D (directAnnotation).
ITGB1jaspar__MA1483.2ELF2 (directAnnotation).
ITGB1metacluster_151.2ZNF23 (directAnnotation).
ITGB1metacluster_170.2KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
ITGB1transfac_pro__M05479ZNF580 (directAnnotation).
ITGB1metacluster_155.23BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ITGB1kznf__ZNF783_Imbeault2017_OM_MEMEZNF783 (directAnnotation).
ITGB1metacluster_144.3ZNF704; ZNF704 (directAnnotation).
ITGB1metacluster_182.10ZFX (directAnnotation).
ITGB1hdpi__ETV4ETV4 (directAnnotation).
ITGB1jaspar__MA0748.2YY2 (directAnnotation).
ITGB1homer__TWVGGTCCGC_HINFPHINFP (directAnnotation).
ITGB1metacluster_135.10MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ITGB1jaspar__MA0079.5SP1 (directAnnotation).
ITGB1taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAPETV1; GCM1 (directAnnotation).
ITGB1jaspar__MA1106.1HIF1A (directAnnotation).
ITGB1transfac_pro__M05768ZNF544 (directAnnotation).
ITGB1metacluster_22.12NFE2; NFE2L1 (directAnnotation).
ITGB1transfac_pro__M06363ZNF730 (directAnnotation).
ITGB1metacluster_20.3BARHL2; BARHL2 (directAnnotation).
ITGB1metacluster_9.47PAX7 (inferredBy_Orthology).
ITGB1transfac_pro__M01783SP2 (directAnnotation).
ITGB1metacluster_22.28BACH1 (directAnnotation).
ITGB1transfac_pro__M12441ZNF281 (inferredBy_Orthology).
ITGB1kznf__ZNF490_Schmitges2016_ChIP-seqZNF490 (directAnnotation).
ITGB1taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_reprCREB1 (directAnnotation).
ITGB1transfac_pro__M06097ZNF14 (directAnnotation).
ITGB1metacluster_111.4ATF1; ATF1; ATF1; ATF1; ATF1; ATF1; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF3; ATF3; ATF3; ATF4; ATF4; ATF5; ATF6; ATF6B; ATF7; ATF7; ATF7; BATF3; BATF3; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB1; CREB3; CREB3L4; CREB3L4; CREB5; CREB5; CREB5; CREM; CREM; CREM; CREM; CREM; FOSB; FOSL1; FOSL1; FOSL2; JDP2; JDP2; JDP2; JUN; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; XBP1; XBP1; XBP1; ZNF629 (directAnnotation). ATF1; ATF1; ATF1; ATF2; ATF2; ATF3; ATF6; ATF6B; ATF7; ATF7; ATF7; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; ATF7-NPFF; BATF; BATF2; BATF3; CREB1; CREB1; CREB3; CREB3L1; CREB3L2; CREB3L3; CREB3L4; CREM; FOS; FOSB; FOSL1; FOSL2; JDP2; JDP2 (inferredBy_Orthology).
ITGB1metacluster_141.2E2F2; E2F3 (directAnnotation).
ITGB1transfac_pro__M01251E2F1 (directAnnotation).
ITGB1taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_reprZNF385D (directAnnotation).
ITGB1metacluster_130.1ZNF713; ZNF713 (directAnnotation). HSF1; HSF2; HSF4; HSF5; HSFX1; HSFX2; HSFX3; HSFX4; HSFY1; HSFY2 (inferredBy_Orthology).
ITGB1transfac_pro__M01000AIRE (directAnnotation).
ITGB1metacluster_141.6MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
ITGB1tfdimers__MD00186NFATC3; SPI1 (directAnnotation).
ITGB1metacluster_180.3ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).
ITGB1tfdimers__MD00376HOXA13; KLF4 (directAnnotation).
ITGB1transfac_pro__M05547PLAGL1 (inferredBy_Orthology).
ITGB1transfac_pro__M05794ZNF621 (directAnnotation).
ITGB1transfac_pro__M06104ZNF16 (directAnnotation).
ITGB1metacluster_132.4MEF2B; MEF2B; MEF2B; MEF2B; MEF2C; MEF2C; MEF2D; MEF2D; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF; SRF (directAnnotation). SRF; SRF; SRF; SRF (inferredBy_Orthology).
ITGB1transfac_pro__M06209ZNF616 (directAnnotation).
ITGB1taipale_tf_pairs__FOXJ2_PITX1_NTAATCCNNWMAACA_CAP_reprFOXJ2; PITX1 (directAnnotation).
ITGB1transfac_pro__M01660GABPA (directAnnotation).
ITGB1hdpi__FOXM1FOXM1 (directAnnotation).
ITGB1transfac_pro__M06857ZNF611 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.
Target nameDrug nameDrug IDDrug type
ITGB1"Antithymocyte immunoglobulin (rabbit)"

DB00098

biotech
ITGB1"PLN-74809"

DB16515

small molecule
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1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."