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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ITCH

Summary for ITCH

Gene information	Gene symbol	ITCH
	Ensembl ID	ENSG00000078747
	Entrez ID	83737
	Gene name	itchy E3 ubiquitin protein ligase
	Synonyms	AIP4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: ITCH

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.339224	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.372092	0.00e+00

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Expression of ITCH in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ITCH

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ITCH

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ITCH	hsa-miR-548e-5p	99.6595	NM_001257137
ITCH	hsa-miR-3121-3p	97.839	NM_001257138
ITCH	hsa-miR-5000-5p	97.3955	NM_001257138
ITCH	hsa-miR-1252-5p	97.1696	NM_001257138
ITCH	hsa-miR-548c-3p	96.9523	NM_001257137
ITCH	hsa-miR-1252-3p	96.6211	NM_001257138
ITCH	hsa-miR-875-3p	96.0445	NM_001257138
ITCH	hsa-miR-1264	95.5279	NM_001257137
ITCH	hsa-miR-3148	95.0651	NM_001257138
ITCH	hsa-let-7f-1-3p	94.719	NM_001257137
ITCH	hsa-let-7b-3p	94.719	NM_001257137
ITCH	hsa-let-7a-3p	94.719	NM_001257137
ITCH	hsa-miR-98-3p	94.719	NM_001257137
ITCH	hsa-miR-499b-5p	94.1592	NM_001257138
ITCH	hsa-miR-670-5p	93.1755	NM_001257138
ITCH	hsa-miR-3646	93.0646	NM_001257138
ITCH	hsa-miR-300	92.9985	NM_001257137
ITCH	hsa-miR-381-3p	92.9985	NM_001257137
ITCH	hsa-miR-514a-3p	92.385	NM_001257137
ITCH	hsa-miR-514b-3p	92.385	NM_001257137
ITCH	hsa-miR-617	91.7966	NM_001257137
ITCH	hsa-miR-6728-3p	91.1953	NM_001257137
ITCH	hsa-miR-4282	90.6563	NM_001257137
ITCH	hsa-miR-4492	90.2764	NM_001257137
ITCH	hsa-miR-6516-5p	90.0315	NM_001257138
ITCH	hsa-miR-628-3p	89.8987	NM_001257137
ITCH	hsa-miR-3145-3p	89.6124	NM_001257138
ITCH	hsa-miR-651-3p	89.4427	NM_001257138
ITCH	hsa-miR-496	89.3614	NM_001257138
ITCH	hsa-miR-345-3p	89.3502	NM_001257137
ITCH	hsa-miR-4776-5p	89.232	NM_001257138
ITCH	hsa-miR-4498	89.1747	NM_001257137
ITCH	hsa-miR-3188	88.6452	NM_001257137
ITCH	hsa-miR-3184-3p	88.5745	NM_001257137
ITCH	hsa-miR-3674	88.39	NM_001257138
ITCH	hsa-miR-5001-5p	88.242	NM_001257137
ITCH	hsa-miR-3125	86.8103	NM_001257138
ITCH	hsa-miR-1825	86.6497	NM_001257137
ITCH	hsa-miR-190a-3p	86.4641	NM_001257137
ITCH	hsa-miR-520g-3p	86.0527	NM_001257137
ITCH	hsa-miR-520h	86.0527	NM_001257137
ITCH	hsa-miR-513a-3p	85.96	NM_001257137
ITCH	hsa-miR-513c-3p	85.96	NM_001257137
ITCH	hsa-miR-3606-3p	85.96	NM_001257137
ITCH	hsa-miR-3140-5p	85.8908	NM_001257137
ITCH	hsa-miR-21-5p	85.7833	NM_001257138
ITCH	hsa-miR-138-2-3p	85.454	NM_001257137
ITCH	hsa-miR-7845-5p	85.3561	NM_001257138
ITCH	hsa-miR-762	85.2394	NM_001257137
ITCH	hsa-miR-1299	84.5079	NM_001257138

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Motifs and transcription factors (TFs) regulating ITCH

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ITCH	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
ITCH	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
ITCH	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
ITCH	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
ITCH	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
ITCH	jaspar__MA1721.1	ZNF93 (directAnnotation).
ITCH	metacluster_151.2	ZNF23 (directAnnotation).
ITCH	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
ITCH	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
ITCH	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
ITCH	transfac_pro__M01199	TRIM28 (directAnnotation).
ITCH	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
ITCH	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
ITCH	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
ITCH	transfac_pro__M01253	CNOT3 (directAnnotation).
ITCH	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
ITCH	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
ITCH	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
ITCH	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
ITCH	cisbp__M00968	MTF2 (directAnnotation).
ITCH	jaspar__MA0748.2	YY2 (directAnnotation).
ITCH	metacluster_160.20	JUND; PRDM15 (directAnnotation).
ITCH	metacluster_7.13	ZFX (directAnnotation).
ITCH	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
ITCH	swissregulon__hs__CHD1	CHD1 (directAnnotation).
ITCH	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
ITCH	kznf__ZNF383_Imbeault2017_OM_RCADE	ZNF383 (directAnnotation).
ITCH	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
ITCH	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
ITCH	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
ITCH	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
ITCH	cisbp__M01863	ZNF711 (inferredBy_Orthology).
ITCH	transfac_pro__M07310	SP5 (directAnnotation).
ITCH	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
ITCH	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
ITCH	transfac_pro__M00938	E2F1 (directAnnotation).
ITCH	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
ITCH	transfac_pro__M04893	TAF1 (directAnnotation).
ITCH	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
ITCH	transfac_pro__M04817	ZBTB33 (directAnnotation).
ITCH	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
ITCH	transfac_pro__M12697	ZNF142 (directAnnotation).
ITCH	metacluster_175.1	ZNF283 (directAnnotation).
ITCH	cisbp__M00788	ZFY (inferredBy_Orthology).
ITCH	tfdimers__MD00364	WT1 (directAnnotation).
ITCH	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
ITCH	hdpi__ZNF304	ZNF304 (directAnnotation).
ITCH	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
ITCH	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
ITCH	transfac_pro__M04916	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."