Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ISL1

Summary for ISL1

Gene information	Gene symbol	ISL1
	Ensembl ID	ENSG00000016082
	Entrez ID	3670
	Gene name	ISL LIM homeobox 1
	Synonyms	Isl-1\|ISLET1
	Gene type	protein_coding
	UniProtAcc	P61371

Top

Dataset with differentially expressed gene: ISL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	-0.306502	0.00e+00

Top

Expression of ISL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to ISL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating ISL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ISL1	hsa-miR-143-5p	95.2473	NM_002202
ISL1	hsa-miR-2392	95.0555	NM_002202
ISL1	hsa-miR-371b-5p	94.9742	NM_002202
ISL1	hsa-miR-373-5p	94.9742	NM_002202
ISL1	hsa-miR-616-5p	94.9742	NM_002202
ISL1	hsa-miR-3613-3p	94.3423	NM_002202
ISL1	hsa-miR-499b-5p	93.7168	NM_002202
ISL1	hsa-miR-519e-5p	93.0767	NM_002202
ISL1	hsa-miR-515-5p	93.0767	NM_002202
ISL1	hsa-miR-4789-3p	92.6485	NM_002202
ISL1	hsa-miR-3065-3p	92.6069	NM_002202
ISL1	hsa-miR-33a-3p	91.7669	NM_002202
ISL1	hsa-miR-3606-5p	91.7443	NM_002202
ISL1	hsa-miR-216a-3p	91.6246	NM_002202
ISL1	hsa-miR-128-3p	91.6246	NM_002202
ISL1	hsa-miR-6809-5p	91.2225	NM_002202
ISL1	hsa-miR-6503-3p	90.881	NM_002202
ISL1	hsa-miR-3658	89.8473	NM_002202
ISL1	hsa-miR-1275	88.9267	NM_002202
ISL1	hsa-miR-3681-3p	88.6212	NM_002202
ISL1	hsa-miR-3156-3p	88.0123	NM_002202
ISL1	hsa-miR-106a-3p	87.7247	NM_002202
ISL1	hsa-miR-371a-5p	87.5014	NM_002202
ISL1	hsa-miR-4695-3p	87.1557	NM_002202
ISL1	hsa-miR-545-3p	86.924	NM_002202
ISL1	hsa-miR-3688-5p	86.8793	NM_002202
ISL1	hsa-miR-652-3p	86.6847	NM_002202
ISL1	hsa-miR-4668-5p	86.3339	NM_002202
ISL1	hsa-miR-6838-3p	86.1462	NM_002202
ISL1	hsa-miR-5695	85.1792	NM_002202
ISL1	hsa-miR-519d-5p	85.1792	NM_002202
ISL1	hsa-miR-4665-5p	84.7589	NM_002202
ISL1	hsa-miR-6766-3p	82.2368	NM_002202
ISL1	hsa-miR-4782-3p	82.2368	NM_002202
ISL1	hsa-miR-219a-5p	82.2368	NM_002202
ISL1	hsa-miR-4668-3p	81.9726	NM_002202
ISL1	hsa-miR-576-3p	81.2776	NM_002202
ISL1	hsa-miR-8068	80.843	NM_002202
ISL1	hsa-miR-6505-3p	80.2165	NM_002202

Page: 1

Top

Motifs and transcription factors (TFs) regulating ISL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
ISL1	jaspar__MA1483.2	ELF2 (directAnnotation).
ISL1	transfac_pro__M05481	ZNF202 (directAnnotation).
ISL1	transfac_pro__M05298	OVOL3 (directAnnotation).
ISL1	metacluster_33.5	MTF1 (inferredBy_Orthology).
ISL1	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
ISL1	tfdimers__MD00275	POU2F1; TFAP2A (directAnnotation).
ISL1	transfac_pro__M04848	TAF1 (directAnnotation).
ISL1	transfac_pro__M05488	ZSCAN5B (directAnnotation).
ISL1	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."