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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: ISCU

Summary for ISCU

Gene informationGene symbol

ISCU

Ensembl ID

ENSG00000136003

Entrez ID

23479

Gene nameiron-sulfur cluster assembly enzyme
SynonymshnifU|ISU2|NIFUN
Gene typeprotein_coding
UniProtAcc

Q9H1K1


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Dataset with differentially expressed gene: ISCU

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-0.3698621.25e-22

GSE163836

FCIBC02 cell lineCell lineBreast cancerInflammatory breast cancerChemotherapypaclitaxelNAMalignant cells-0.6044410.00e+00

GSE169246_PacBlood

patientsPeripheral blood mononuclear cellsBreast cancerAdvanced triple-negative breast cancer (TNBC)ChemotherapypaclitaxelpostPlasma cells0.3313349.16e-07

GSE150930

patientsPeripheral blood mononuclear cellsChronic lymphocytic leukemiaMucosa-assisted lymphoid tissue (MALT) lymphomaImmunotherapyrituximab + cyclophosphamide + fludarabineNAMalignant cells0.2684862.03e-10

GSE161801_PI

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapycarfilzomib + dexamethasonepreMalignant cells0.4578397.89e-24

GSE161195

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapyDARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)postMalignant cells-0.3197514.87e-41

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostErythrocytes0.3647750.00e+00

GSE131984_JQ1Pal

SUM159 cell lineCell lineBreast cancerTriple-negative breast cancer (TNBC)Targeted therapyJQ1 + palbociclibNAMalignant cells-0.270498.11e-15

GSE161801_IMiD

patientsBone marrow aspirateMultiple myelomaRefractory multiple myeloma (MM)Targeted therapypomalidomide + dexamethasone OR lenalidomide + dexamethasonepostMalignant cells-0.5199130.00e+00

GSE175716

PDXTumor tissueLiver cancerAdvanced hepatocellular carcinomaTargeted therapysorafenibNAMalignant cells0.3628975.63e-23

GSE115251

Kelly cell lineCell lineNeuroblastomaNeuroblastomaTargeted therapyTAE684NAMalignant cells0.3621350.00e+00

GSE164897_VemCob

A375 cell lineCell lineMelanomaBRAFV600E-mutant melanomaTargeted therapyvemurafenib + combimetinibNAMalignant cells-0.5377720.00e+00

GSE164897_VemTra

A375 cell lineCell lineMelanomaB+E2:E57RAFV600E-mutant melanomaTargeted therapyvemurafenib + trametinibNAMalignant cells-0.2918510.00e+00

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Expression of ISCU in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to ISCU

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ISCU

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
ISCUhsa-miR-5011-5p97.3678NM_014301
ISCUhsa-miR-6730-3p93.9216NM_001320042
ISCUhsa-miR-314893.2063NM_001320042
ISCUhsa-miR-210-3p91.4776NM_014301
ISCUhsa-miR-378g91.4657NM_001320042
ISCUhsa-miR-431990.935NM_001320042
ISCUhsa-miR-848589.3596NM_014301
ISCUhsa-miR-125a-5p88.1467NM_001320042
ISCUhsa-miR-125b-5p88.1467NM_001320042
ISCUhsa-miR-4652-5p87.1436NM_001320042
ISCUhsa-let-7c-3p85.846NM_001320042
ISCUhsa-miR-589-3p85.6535NM_014301
ISCUhsa-miR-120084.9306NM_001320042
ISCUhsa-miR-6882-5p84.2798NM_001320042
ISCUhsa-miR-4795-3p82.6797NM_001320042
ISCUhsa-miR-6885-3p82.5672NM_014301
ISCUhsa-miR-568082.3583NM_001320042
ISCUhsa-miR-3529-3p82.1891NM_014301
ISCUhsa-miR-6770-5p81.5123NM_001320042
ISCUhsa-miR-190a-3p81.4311NM_014301
ISCUhsa-miR-311580.2966NM_001320042
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Motifs and transcription factors (TFs) regulating ISCU

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
ISCUswissregulon__hs__ZBTB14ZBTB14 (directAnnotation).
ISCUhdpi__FLI1FLI1 (directAnnotation).
ISCUtransfac_pro__M05605GATA6 (inferredBy_Orthology).
ISCUkznf__ZNF384_Schmitges2016_RCADEZNF384 (directAnnotation).
ISCUtransfac_pro__M05550SNAPC4 (inferredBy_Orthology).
ISCUjaspar__MA1967.1TFAP4 (directAnnotation).
ISCUmetacluster_166.4BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
ISCUmetacluster_166.2ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
ISCUswissregulon__hs__ELF2ELF2 (directAnnotation).
ISCUtaipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAPETV5; FOXI1 (directAnnotation).
ISCUswissregulon__hs__ETV6ETV6 (directAnnotation).
ISCUtaipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_reprELK1; EOMES (directAnnotation).
ISCUmetacluster_55.3E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
ISCUtransfac_pro__M00652NRF1 (directAnnotation).
ISCUmetacluster_141.2E2F2; E2F3 (directAnnotation).
ISCUtransfac_pro__M06592ZNF486 (directAnnotation).
ISCUtaipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAPELK1; TBX21 (directAnnotation).
ISCUtransfac_pro__M06071ZNF814 (directAnnotation).
ISCUtransfac_pro__M06362ZNF730 (directAnnotation).
ISCUhomer__ATTGCGCAAC_CEBPCEBPB (inferredBy_Orthology).
ISCUtaipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_reprETV2; HES7 (directAnnotation).
ISCUtaipale_tf_pairs__ERF_FOXI1_TGTTKMCGGAWRN_CAP_reprERF; FOXI1 (directAnnotation).
ISCUmetacluster_81.7CREB1 (directAnnotation).
ISCUtaipale_tf_pairs__ERF_MAX_RSCGGAANCACGTGN_CAP_reprERF; MAX (directAnnotation).
ISCUtaipale_tf_pairs__FLI1_FOXI1_GAAAACCGAAAN_CAP_reprFLI1; FOXI1 (directAnnotation).
ISCUtaipale_tf_pairs__FLI1_MAX_RSCGGAANCACGTGN_CAPFLI1; MAX (directAnnotation).
ISCUjaspar__MA0775.1MEIS3 (directAnnotation).
ISCUtransfac_pro__M06468ZNF808 (directAnnotation).
ISCUtaipale_tf_pairs__HOXB2_TBX3_AGGTGTTAATKN_CAPHOXB2; TBX3 (directAnnotation).
ISCUtfdimers__MD00463CHURC1; DBP (directAnnotation).
ISCUtransfac_pro__M04748GABPA (directAnnotation).
ISCUtransfac_public__M00041ATF2; JUN (directAnnotation).
ISCUtransfac_pro__M05543ZSCAN12 (inferredBy_Orthology).
ISCUswissregulon__hs__OVOL1OVOL1 (directAnnotation).
ISCUmetacluster_95.2ZNF778 (directAnnotation).
ISCUjaspar__MA1934.1FIGLA (directAnnotation).
ISCUtaipale_tf_pairs__MGA_DLX3_AGGTGNTAATKR_CAPDLX3; MGA (directAnnotation).
ISCUtransfac_pro__M05566ZSCAN25 (directAnnotation).
ISCUtaipale_tf_pairs__MGA_DLX2_AGGTGNTAATTR_CAPDLX2; MGA (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."