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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor
	Acts as a drug target< (This gene does not contain this module)

Gene: IRX3

Summary for IRX3

Gene information	Gene symbol	IRX3
	Ensembl ID	ENSG00000177508
	Entrez ID	79191
	Gene name	iroquois homeobox 3
	Synonyms	IRX-1
	Gene type	protein_coding
	UniProtAcc	P78415

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Dataset with differentially expressed gene: IRX3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.489801	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.267437	4.56e-04

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Expression of IRX3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IRX3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IRX3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IRX3	hsa-miR-98-3p	95.9053	NM_024336
IRX3	hsa-let-7a-3p	95.9053	NM_024336
IRX3	hsa-let-7f-1-3p	95.9053	NM_024336
IRX3	hsa-let-7b-3p	95.9053	NM_024336
IRX3	hsa-miR-4789-5p	95.2941	NM_024336
IRX3	hsa-miR-1185-2-3p	94.7024	NM_024336
IRX3	hsa-miR-1185-1-3p	94.7024	NM_024336
IRX3	hsa-let-7f-2-3p	93.9992	NM_024336
IRX3	hsa-miR-4662a-5p	93.8876	NM_024336
IRX3	hsa-miR-4666a-3p	91.7304	NM_024336
IRX3	hsa-miR-6885-3p	89.7726	NM_024336
IRX3	hsa-miR-659-3p	88.8695	NM_024336
IRX3	hsa-miR-6844	87.6147	NM_024336
IRX3	hsa-miR-6509-5p	86.6047	NM_024336
IRX3	hsa-miR-4729	84.9563	NM_024336
IRX3	hsa-miR-377-3p	82.8895	NM_024336
IRX3	hsa-miR-1304-3p	82.7952	NM_024336
IRX3	hsa-miR-7849-3p	81.5519	NM_024336
IRX3	hsa-miR-493-5p	81.184	NM_024336

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Motifs and transcription factors (TFs) regulating IRX3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IRX3	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
IRX3	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
IRX3	cisbp__M00341	PAX6 (directAnnotation).
IRX3	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

TF	motif	Expression	Cell type	Dataset	Timepoint
IRX3	metacluster_175.5	up	Malignant cells	GSE207422_Tor	post

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."