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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IRS2

Summary for IRS2

Gene information	Gene symbol	IRS2
	Ensembl ID	ENSG00000185950
	Entrez ID	8660
	Gene name	insulin receptor substrate 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9Y4H2

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Dataset with differentially expressed gene: IRS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.70459	2.24e-03
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	-0.61738	3.43e-32
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.338221	3.95e-17
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.487455	1.37e-11
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.684236	4.88e-30
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.787299	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.401257	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.285563	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.629625	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.484708	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	1.46589	0.00e+00

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Expression of IRS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IRS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IRS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IRS2	hsa-miR-190a-3p	98.4268	NM_003749
IRS2	hsa-miR-448	98.2169	NM_003749
IRS2	hsa-miR-548p	97.9663	NM_003749
IRS2	hsa-miR-935	96.4127	NM_003749
IRS2	hsa-miR-7-5p	94.7518	NM_003749
IRS2	hsa-miR-944	94.0771	NM_003749
IRS2	hsa-miR-561-3p	93.5054	NM_003749
IRS2	hsa-miR-302c-5p	92.4536	NM_003749
IRS2	hsa-miR-570-3p	91.9876	NM_003749
IRS2	hsa-miR-4291	90.0904	NM_003749
IRS2	hsa-miR-4500	88.5596	NM_003749
IRS2	hsa-miR-3611	87.7544	NM_003749
IRS2	hsa-miR-532-5p	87.5463	NM_003749
IRS2	hsa-miR-4317	87.3226	NM_003749
IRS2	hsa-miR-451b	87.1887	NM_003749
IRS2	hsa-miR-218-1-3p	86.5719	NM_003749
IRS2	hsa-miR-659-3p	86.0746	NM_003749
IRS2	hsa-let-7i-5p	85.4492	NM_003749
IRS2	hsa-miR-98-5p	85.4492	NM_003749
IRS2	hsa-let-7g-5p	85.4492	NM_003749
IRS2	hsa-let-7a-5p	85.4492	NM_003749
IRS2	hsa-let-7f-5p	85.4492	NM_003749
IRS2	hsa-let-7c-5p	85.4492	NM_003749
IRS2	hsa-let-7b-5p	85.4492	NM_003749
IRS2	hsa-let-7e-5p	85.4492	NM_003749
IRS2	hsa-miR-4742-5p	85.3965	NM_003749
IRS2	hsa-miR-1208	85.2368	NM_003749
IRS2	hsa-miR-5011-5p	85.0697	NM_003749
IRS2	hsa-miR-4458	85.0616	NM_003749
IRS2	hsa-miR-6501-3p	84.7233	NM_003749
IRS2	hsa-miR-5692a	84.5561	NM_003749
IRS2	hsa-miR-6846-3p	84.3174	NM_003749
IRS2	hsa-miR-181d-5p	84.0445	NM_003749
IRS2	hsa-miR-4262	84.0445	NM_003749
IRS2	hsa-miR-3686	83.7786	NM_003749
IRS2	hsa-miR-92b-3p	83.7465	NM_003749
IRS2	hsa-miR-92a-3p	83.7465	NM_003749
IRS2	hsa-miR-32-5p	83.7465	NM_003749
IRS2	hsa-miR-200a-3p	83.4848	NM_003749
IRS2	hsa-miR-141-3p	83.4848	NM_003749
IRS2	hsa-miR-3121-3p	82.7386	NM_003749
IRS2	hsa-miR-181c-5p	81.3259	NM_003749
IRS2	hsa-miR-181a-5p	81.3259	NM_003749
IRS2	hsa-miR-181b-5p	81.3259	NM_003749
IRS2	hsa-miR-7856-5p	81.262	NM_003749
IRS2	hsa-let-7d-5p	80.7938	NM_003749
IRS2	hsa-miR-7160-5p	80.6032	NM_003749
IRS2	hsa-miR-3617-5p	80.2025	NM_003749
IRS2	hsa-miR-641	80.2025	NM_003749

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Motifs and transcription factors (TFs) regulating IRS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IRS2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
IRS2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
IRS2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
IRS2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
IRS2	hdpi__ETV4	ETV4 (directAnnotation).
IRS2	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
IRS2	transfac_pro__M06156	ZNF75D (directAnnotation).
IRS2	jaspar__MA1483.2	ELF2 (directAnnotation).
IRS2	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
IRS2	cisbp__M00808	MYPOP (inferredBy_Orthology).
IRS2	taipale_tf_pairs__HOXB2_ELF1_SMGGAAGTMRTTA_CAP	ELF1; HOXB2 (directAnnotation).
IRS2	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
IRS2	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
IRS2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
IRS2	jaspar__MA1957.1	ELK1 (directAnnotation).
IRS2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
IRS2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
IRS2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
IRS2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
IRS2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
IRS2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
IRS2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
IRS2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
IRS2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
IRS2	transfac_pro__M00652	NRF1 (directAnnotation).
IRS2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
IRS2	transfac_pro__M04866	HDAC2 (directAnnotation).
IRS2	jaspar__MA1122.1	TFDP1 (directAnnotation).
IRS2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
IRS2	taipale_tf_pairs__ETV2_HES7_RSCGGAANNNNNNCACGTGNN_CAP_repr	ETV2; HES7 (directAnnotation).
IRS2	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
IRS2	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
IRS2	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
IRS2	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
IRS2	transfac_pro__M04617	ZBTB7A (directAnnotation).
IRS2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
IRS2	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
IRS2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
IRS2	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
IRS2	transfac_pro__M07387	ZBTB7A (directAnnotation).
IRS2	transfac_pro__M07436	WT1 (directAnnotation).
IRS2	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
IRS2	transfac_pro__M00716	ZBTB14 (directAnnotation).
IRS2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
IRS2	hdpi__HIP2	UBE2K (directAnnotation).
IRS2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
IRS2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
IRS2	transfac_pro__M04893	TAF1 (directAnnotation).
IRS2	transfac_pro__M03876	ZBTB33 (directAnnotation).
IRS2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."