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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IRF6

Summary for IRF6

Gene information	Gene symbol	IRF6
	Ensembl ID	ENSG00000117595
	Entrez ID	3664
	Gene name	interferon regulatory factor 6
	Synonyms	LPS\|OFC6\|VWS\|VWS1
	Gene type	protein_coding
	UniProtAcc	O14896

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Dataset with differentially expressed gene: IRF6

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.373797	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.464134	2.80e-41

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Expression of IRF6 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IRF6

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IRF6

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IRF6	hsa-let-7c-3p	94.3353	NM_001206696
IRF6	hsa-miR-16-2-3p	93.9806	NM_001206696
IRF6	hsa-miR-195-3p	93.9806	NM_001206696
IRF6	hsa-miR-8081	92.6564	NM_001206696
IRF6	hsa-miR-370-5p	92.633	NM_001206696
IRF6	hsa-miR-6804-5p	91.2811	NM_001206696
IRF6	hsa-miR-876-3p	90.8093	NM_001206696
IRF6	hsa-miR-4786-3p	90.3567	NM_001206696
IRF6	hsa-miR-6859-3p	89.6527	NM_001206696
IRF6	hsa-miR-1208	89.431	NM_001206696
IRF6	hsa-miR-338-5p	89.2663	NM_001206696
IRF6	hsa-miR-4264	89.0965	NM_001206696
IRF6	hsa-miR-6888-5p	88.8374	NM_001206696
IRF6	hsa-miR-4481	87.9861	NM_001206696
IRF6	hsa-miR-548ap-3p	87.346	NM_001206696
IRF6	hsa-miR-548t-3p	87.346	NM_001206696
IRF6	hsa-miR-548aa	87.346	NM_001206696
IRF6	hsa-miR-656-3p	86.4632	NM_001206696
IRF6	hsa-miR-12129	85.945	NM_001206696
IRF6	hsa-miR-4745-5p	85.6014	NM_001206696
IRF6	hsa-miR-6770-5p	85.4445	NM_001206696
IRF6	hsa-miR-5088-3p	83.7354	NM_001206696
IRF6	hsa-miR-6837-3p	83.7133	NM_001206696
IRF6	hsa-miR-4729	83.5161	NM_001206696
IRF6	hsa-miR-4668-3p	83.3229	NM_001206696
IRF6	hsa-miR-6854-5p	83.1929	NM_001206696
IRF6	hsa-miR-10527-5p	82.7873	NM_001206696
IRF6	hsa-miR-587	81.7272	NM_001206696
IRF6	hsa-miR-4429	81.6499	NM_001206696
IRF6	hsa-miR-4663	81.5673	NM_001206696
IRF6	hsa-miR-5197-3p	81.3576	NM_001206696
IRF6	hsa-miR-1238-5p	80.8877	NM_001206696
IRF6	hsa-miR-4758-5p	80.8877	NM_001206696
IRF6	hsa-miR-3915	80.5403	NM_001206696
IRF6	hsa-miR-548c-3p	80.4511	NM_001206696
IRF6	hsa-miR-320a-3p	80.3084	NM_001206696
IRF6	hsa-miR-320d	80.3084	NM_001206696
IRF6	hsa-miR-320c	80.3084	NM_001206696
IRF6	hsa-miR-320b	80.3084	NM_001206696
IRF6	hsa-miR-520b-5p	80.1458	NM_001206696
IRF6	hsa-miR-519a-2-5p	80.1458	NM_001206696

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Motifs and transcription factors (TFs) regulating IRF6

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IRF6	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
IRF6	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
IRF6	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
IRF6	transfac_pro__M06032	ZNF727 (directAnnotation).
IRF6	transfac_pro__M05597	ZNF174 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."