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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: IRAK3

Summary for IRAK3

Gene information	Gene symbol	IRAK3
	Ensembl ID	ENSG00000090376
	Entrez ID	11213
	Gene name	interleukin 1 receptor associated kinase 3
	Synonyms	IRAK-M
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: IRAK3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.566642	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	cDCs	0.278861	1.45e-06
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.471213	1.65e-16

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Expression of IRAK3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IRAK3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IRAK3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IRAK3	hsa-miR-3163	96.9401	NM_001142523
IRAK3	hsa-miR-450a-1-3p	96.6581	NM_001142523
IRAK3	hsa-miR-6853-3p	93.5301	NM_001142523
IRAK3	hsa-miR-4528	92.2971	NM_001142523
IRAK3	hsa-miR-4272	91.2015	NM_001142523
IRAK3	hsa-miR-520d-5p	90.8979	NM_001142523
IRAK3	hsa-miR-524-5p	90.8979	NM_001142523
IRAK3	hsa-miR-329-5p	90.8663	NM_001142523
IRAK3	hsa-miR-627-3p	90.4201	NM_001142523
IRAK3	hsa-miR-3194-5p	89.5585	NM_001142523
IRAK3	hsa-miR-5589-5p	89.5414	NM_001142523
IRAK3	hsa-miR-3646	89.492	NM_001142523
IRAK3	hsa-miR-3613-3p	87.7844	NM_001142523
IRAK3	hsa-miR-576-5p	87.7479	NM_001142523
IRAK3	hsa-miR-95-5p	86.5187	NM_001142523
IRAK3	hsa-miR-4775	85.9182	NM_001142523
IRAK3	hsa-miR-7106-5p	84.1063	NM_001142523
IRAK3	hsa-miR-3664-3p	83.9468	NM_001142523
IRAK3	hsa-miR-607	83.8266	NM_001142523
IRAK3	hsa-miR-153-5p	83.3698	NM_001142523
IRAK3	hsa-miR-12123	83.0162	NM_001142523
IRAK3	hsa-miR-4256	80.0922	NM_001142523
IRAK3	hsa-miR-11181-5p	80.0922	NM_001142523

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Motifs and transcription factors (TFs) regulating IRAK3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IRAK3	hdpi__GTF3C2	GTF3C2 (directAnnotation).
IRAK3	transfac_pro__M03806	ZBTB7C (directAnnotation).
IRAK3	metacluster_198.3	ZFP64 (directAnnotation).
IRAK3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
IRAK3	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
IRAK3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
IRAK3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
IRAK3	metacluster_155.11	SPZ1 (directAnnotation).
IRAK3	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
IRAK3	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
IRAK3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
IRAK3	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
IRAK3	hdpi__HTATIP2	HTATIP2 (directAnnotation).
IRAK3	cisbp__M01733	CCDC169-SOHLH2; SOHLH2 (inferredBy_Orthology).
IRAK3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
IRAK3	tfdimers__MD00343	HIC1; TP53 (directAnnotation).
IRAK3	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
IRAK3	transfac_public__M00005	TFAP4 (directAnnotation).
IRAK3	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
IRAK3	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
IRAK3	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).
IRAK3	metacluster_72.9	SALL2 (directAnnotation). SALL2 (inferredBy_Orthology).
IRAK3	jaspar__MA0131.2	HINFP (directAnnotation).
IRAK3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
IRAK3	transfac_pro__M01240	GTF2IRD1 (directAnnotation).
IRAK3	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
IRAK3	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
IRAK3	jaspar__MA1684.1	FOXN1 (inferredBy_Orthology).
IRAK3	taipale_tf_pairs__ETV2_HOXA2_NCCGGAAGTMATTA_CAP_repr	ETV2; HOXA2 (directAnnotation).
IRAK3	transfac_pro__M06741	ZNF70 (directAnnotation).
IRAK3	metacluster_57.3	ARNT; ATF3; ATF3; ATF3; ATF3; BHLHE40; BHLHE40; BHLHE40; BHLHE41; BHLHE41; BHLHE41; MITF; MITF; MITF; MLX; MLXIPL; SREBF1; SREBF1; SREBF1; SREBF1; SREBF2; SREBF2; SREBF2; TFE3; TFEC; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF1; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; USF2; ZNF507 (directAnnotation). ARNTL; BHLHE40; BHLHE40; BHLHE41; HELT; HES1; HES2; HES3; HES5; HES6; HES7; HEY1; HEY2; HEYL; MLX; MLX; SREBF1; SREBF2; TFE3; USF1; USF1; USF2; USF2 (inferredBy_Orthology).
IRAK3	kznf__ZNF584_Imbeault2017_OM_RCADE	ZNF584 (directAnnotation).
IRAK3	transfac_pro__M05991	ZFP64 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
IRAK3	"Fostamatinib"	DB12010	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."