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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IQGAP3

Summary for IQGAP3

Gene information	Gene symbol	IQGAP3
	Ensembl ID	ENSG00000183856
	Entrez ID	128239
	Gene name	IQ motif containing GTPase activating protein 3
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q86VI3

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Dataset with differentially expressed gene: IQGAP3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Physiology B cells	-0.620152	2.02e-03

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Expression of IQGAP3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IQGAP3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IQGAP3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IQGAP3	hsa-miR-1180-5p	97.7008	NM_178229
IQGAP3	hsa-miR-7114-3p	97.1322	NM_178229
IQGAP3	hsa-miR-4662a-5p	92.5075	NM_178229
IQGAP3	hsa-miR-5584-5p	89.126	NM_178229
IQGAP3	hsa-miR-1229-5p	88.9421	NM_178229
IQGAP3	hsa-miR-6878-5p	88.4317	NM_178229
IQGAP3	hsa-miR-127-5p	88.0599	NM_178229
IQGAP3	hsa-miR-302a-5p	88.0548	NM_178229
IQGAP3	hsa-miR-3670	87.766	NM_178229
IQGAP3	hsa-miR-6812-5p	87.5018	NM_178229
IQGAP3	hsa-miR-6737-5p	86.3558	NM_178229
IQGAP3	hsa-miR-6819-5p	86.3558	NM_178229
IQGAP3	hsa-miR-503-3p	85.0014	NM_178229
IQGAP3	hsa-miR-6796-5p	84.2698	NM_178229
IQGAP3	hsa-miR-4447	84.1334	NM_178229
IQGAP3	hsa-miR-3116	82.6429	NM_178229

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Motifs and transcription factors (TFs) regulating IQGAP3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IQGAP3	swissregulon__hs__ZNF691	ZNF691 (directAnnotation).
IQGAP3	metacluster_8.1	ZNF382 (directAnnotation).
IQGAP3	transfac_pro__M06968	ZNF467 (inferredBy_Orthology).
IQGAP3	transfac_pro__M12556	ETV4 (directAnnotation).
IQGAP3	metacluster_84.15	RARB (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."