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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IPMK

Summary for IPMK

Gene information	Gene symbol	IPMK
	Ensembl ID	ENSG00000151151
	Entrez ID	253430
	Gene name	inositol polyphosphate multikinase
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q8NFU5

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Dataset with differentially expressed gene: IPMK

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.342071	0.00e+00

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Expression of IPMK in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IPMK

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IPMK

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IPMK	hsa-miR-3163	99.9918	NM_152230
IPMK	hsa-miR-340-5p	99.9199	NM_152230
IPMK	hsa-miR-4520-3p	98.7512	NM_152230
IPMK	hsa-miR-3973	97.5137	NM_152230
IPMK	hsa-miR-524-5p	96.6393	NM_152230
IPMK	hsa-miR-520d-5p	96.6393	NM_152230
IPMK	hsa-miR-7161-5p	96.1921	NM_152230
IPMK	hsa-miR-3613-3p	95.9169	NM_152230
IPMK	hsa-miR-582-5p	95.8744	NM_152230
IPMK	hsa-miR-9985	95.7145	NM_152230
IPMK	hsa-miR-27b-3p	95.7145	NM_152230
IPMK	hsa-miR-27a-3p	95.7145	NM_152230
IPMK	hsa-miR-1185-2-3p	95.7085	NM_152230
IPMK	hsa-let-7f-2-3p	95.7085	NM_152230
IPMK	hsa-miR-1185-1-3p	95.7085	NM_152230
IPMK	hsa-miR-548ar-3p	95.2384	NM_152230
IPMK	hsa-miR-548e-3p	94.9782	NM_152230
IPMK	hsa-miR-548a-3p	94.7391	NM_152230
IPMK	hsa-miR-3662	94.5951	NM_152230
IPMK	hsa-miR-548f-5p	94.317	NM_152230
IPMK	hsa-miR-548x-5p	94.317	NM_152230
IPMK	hsa-miR-548g-5p	94.317	NM_152230
IPMK	hsa-miR-548aj-5p	94.317	NM_152230
IPMK	hsa-miR-548f-3p	94.3137	NM_152230
IPMK	hsa-miR-548az-3p	94.3137	NM_152230
IPMK	hsa-miR-548bc	94.3137	NM_152230
IPMK	hsa-miR-548n	94.1728	NM_152230
IPMK	hsa-miR-1200	93.9404	NM_152230
IPMK	hsa-miR-548u	93.7602	NM_152230
IPMK	hsa-miR-23c	93.6725	NM_152230
IPMK	hsa-miR-576-5p	93.2911	NM_152230
IPMK	hsa-miR-145-5p	93.1199	NM_152230
IPMK	hsa-miR-1468-3p	93.1079	NM_152230
IPMK	hsa-miR-23a-3p	92.9689	NM_152230
IPMK	hsa-miR-23b-3p	92.9689	NM_152230
IPMK	hsa-miR-548l	92.3824	NM_152230
IPMK	hsa-miR-380-3p	92.1474	NM_152230
IPMK	hsa-miR-33a-3p	92.1464	NM_152230
IPMK	hsa-miR-3925-3p	91.9169	NM_152230
IPMK	hsa-miR-5195-3p	91.4497	NM_152230
IPMK	hsa-miR-4262	91.2131	NM_152230
IPMK	hsa-miR-583	90.5771	NM_152230
IPMK	hsa-miR-181d-5p	90.2451	NM_152230
IPMK	hsa-miR-181b-5p	90.2451	NM_152230
IPMK	hsa-miR-181c-5p	90.2451	NM_152230
IPMK	hsa-miR-181a-5p	90.2451	NM_152230
IPMK	hsa-miR-378a-5p	89.4466	NM_152230
IPMK	hsa-miR-7154-5p	89.3919	NM_152230
IPMK	hsa-miR-4317	88.9158	NM_152230
IPMK	hsa-miR-4324	88.9005	NM_152230

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Motifs and transcription factors (TFs) regulating IPMK

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IPMK	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
IPMK	metacluster_160.20	JUND; PRDM15 (directAnnotation).
IPMK	metacluster_154.2	PAX1; PAX2; PAX2; PAX2; PAX2; PAX4; PAX4; PAX4; PAX4; PAX4; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX5; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX6; PAX8; PAX8; PAX9 (directAnnotation). PAX1; PAX1; PAX1; PAX5; PAX6; PAX6 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."