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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: INPP5F

Summary for INPP5F

Gene information	Gene symbol	INPP5F
	Ensembl ID	ENSG00000198825
	Entrez ID	22876
	Gene name	inositol polyphosphate-5-phosphatase F
	Synonyms	hSac2\|KIAA0966\|SAC2
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: INPP5F

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	-0.282599	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.475213	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.408806	0.00e+00

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Expression of INPP5F in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to INPP5F

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating INPP5F

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
INPP5F	hsa-miR-5692a	97.5865	NM_001243194
INPP5F	hsa-miR-5089-5p	94.0338	NM_014937
INPP5F	hsa-miR-513b-5p	92.9733	NM_014937
INPP5F	hsa-miR-548e-5p	92.7371	NM_001243194
INPP5F	hsa-miR-1324	92.0947	NM_014937
INPP5F	hsa-miR-548am-3p	91.6931	NM_001243194
INPP5F	hsa-miR-548j-3p	91.6931	NM_001243194
INPP5F	hsa-miR-548ae-3p	91.6931	NM_001243194
INPP5F	hsa-miR-548ah-3p	91.6931	NM_001243194
INPP5F	hsa-miR-548aq-3p	91.6931	NM_001243194
INPP5F	hsa-miR-548aj-3p	91.6084	NM_001243194
INPP5F	hsa-miR-548x-3p	91.6084	NM_001243194
INPP5F	hsa-miR-20b-3p	91.1342	NM_014937
INPP5F	hsa-miR-3685	90.4147	NM_001243195
INPP5F	hsa-miR-142-3p	88.3394	NM_014937
INPP5F	hsa-miR-96-3p	87.2743	NM_001243195
INPP5F	hsa-miR-155-3p	83.3231	NM_001243195
INPP5F	hsa-miR-4328	82.938	NM_001243195
INPP5F	hsa-miR-1323	82.9003	NM_014937
INPP5F	hsa-miR-7853-5p	81.5443	NM_014937
INPP5F	hsa-miR-105-5p	81.5443	NM_014937
INPP5F	hsa-miR-4292	80.594	NM_001243194
INPP5F	hsa-miR-6791-5p	80.594	NM_001243194
INPP5F	hsa-miR-548o-3p	80.2904	NM_014937

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Motifs and transcription factors (TFs) regulating INPP5F

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
INPP5F	taipale_tf_pairs__MGA_DLX2_SYAATTANWGGTGYGA_CAP	DLX2; MGA (directAnnotation).
INPP5F	transfac_public__M00024	E2F1 (directAnnotation).
INPP5F	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
INPP5F	transfac_pro__M05966	ZFP14 (directAnnotation).
INPP5F	metacluster_26.2	ZNF264 (directAnnotation). NKX2-8 (inferredBy_Orthology).
INPP5F	transfac_public__M00040	ATF2 (directAnnotation).
INPP5F	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
INPP5F	transfac_pro__M05298	OVOL3 (directAnnotation).
INPP5F	transfac_pro__M06451	ZNF614 (directAnnotation).
INPP5F	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
INPP5F	dbtfbs__ZNF2_HEK293_ENCSR011CKE_merged_N1	ZNF2 (directAnnotation).
INPP5F	transfac_pro__M05740	ZNF667 (directAnnotation).
INPP5F	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
INPP5F	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
INPP5F	taipale_tf_pairs__ETV5_FOXI1_RSCGGATGTTGN_CAP	ETV5; FOXI1 (directAnnotation).
INPP5F	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
INPP5F	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
INPP5F	hdpi__FLI1	FLI1 (directAnnotation).
INPP5F	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
INPP5F	jaspar__MA1933.1	SREBF2 (directAnnotation).
INPP5F	swissregulon__hs__ETV6	ETV6 (directAnnotation).
INPP5F	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
INPP5F	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
INPP5F	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
INPP5F	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
INPP5F	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
INPP5F	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
INPP5F	cisbp__M08198	ELF1 (directAnnotation).
INPP5F	hdpi__ETV4	ETV4 (directAnnotation).
INPP5F	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
INPP5F	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
INPP5F	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
INPP5F	transfac_pro__M04748	GABPA (directAnnotation).
INPP5F	taipale_tf_pairs__ETV2_TEF_RSCGGAWNTTRCGYAAN_CAP	ETV2; TEF (directAnnotation).
INPP5F	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
INPP5F	cisbp__M02645	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."