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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: INPP4A

Summary for INPP4A

Gene information	Gene symbol	INPP4A
	Ensembl ID	ENSG00000040933
	Entrez ID	3631
	Gene name	inositol polyphosphate-4-phosphatase type I A
	Synonyms	INPP4
	Gene type	protein_coding
	UniProtAcc	Q96PE3

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Dataset with differentially expressed gene: INPP4A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	NK cells	0.264499	0.00e+00

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Expression of INPP4A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to INPP4A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating INPP4A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
INPP4A	hsa-miR-548bb-3p	99.0419	NM_001134225
INPP4A	hsa-miR-548d-3p	98.9106	NM_001134225
INPP4A	hsa-miR-548ac	98.9106	NM_001134225
INPP4A	hsa-miR-548z	98.9106	NM_001134225
INPP4A	hsa-miR-548h-3p	98.9106	NM_001134225
INPP4A	hsa-miR-190a-3p	98.7122	NM_001134224
INPP4A	hsa-miR-5011-5p	98.6783	NM_001134224
INPP4A	hsa-miR-4280	94.6227	NM_001134225
INPP4A	hsa-miR-204-5p	93.8663	NM_001134224
INPP4A	hsa-miR-211-5p	93.8663	NM_001134224
INPP4A	hsa-miR-548an	93.814	NM_001134224
INPP4A	hsa-miR-4690-5p	92.2138	NM_001134225
INPP4A	hsa-miR-548m	91.9743	NM_001134225
INPP4A	hsa-miR-205-5p	91.9309	NM_001134224
INPP4A	hsa-miR-4760-3p	91.7039	NM_001134225
INPP4A	hsa-miR-223-3p	91.1355	NM_001134224
INPP4A	hsa-miR-4635	90.4225	NM_001134224
INPP4A	hsa-miR-3606-5p	89.5721	NM_001134224
INPP4A	hsa-miR-3163	89.5541	NM_001134224
INPP4A	hsa-miR-4475	88.9082	NM_001134225
INPP4A	hsa-miR-548aa	88.6143	NM_001134225
INPP4A	hsa-miR-548ap-3p	88.6143	NM_001134225
INPP4A	hsa-miR-548t-3p	88.6143	NM_001134225
INPP4A	hsa-miR-3117-5p	88.547	NM_001134225
INPP4A	hsa-miR-10522-5p	88.4412	NM_001134224
INPP4A	hsa-miR-7845-5p	87.8913	NM_001134224
INPP4A	hsa-miR-942-3p	87.6519	NM_001134224
INPP4A	hsa-miR-548aj-3p	87.4933	NM_001134225
INPP4A	hsa-miR-548x-3p	87.4933	NM_001134225
INPP4A	hsa-miR-4719	87.3609	NM_001134224
INPP4A	hsa-miR-30e-5p	86.3548	NM_001134224
INPP4A	hsa-miR-30c-5p	86.3548	NM_001134224
INPP4A	hsa-miR-30b-5p	86.3548	NM_001134224
INPP4A	hsa-miR-30d-5p	86.3548	NM_001134224
INPP4A	hsa-miR-30a-5p	86.3548	NM_001134224
INPP4A	hsa-miR-548am-3p	86.197	NM_001134225
INPP4A	hsa-miR-548ah-3p	86.197	NM_001134225
INPP4A	hsa-miR-4666a-3p	86.0346	NM_001134224
INPP4A	hsa-miR-4729	83.7368	NM_001134225
INPP4A	hsa-miR-455-5p	83.4994	NM_001134225
INPP4A	hsa-miR-6740-3p	83.3587	NM_001134224
INPP4A	hsa-miR-548ae-3p	83.1747	NM_001134225
INPP4A	hsa-miR-548j-3p	83.1747	NM_001134225
INPP4A	hsa-miR-548aq-3p	83.1747	NM_001134225
INPP4A	hsa-miR-497-3p	82.8961	NM_001134225
INPP4A	hsa-miR-6832-3p	82.5804	NM_001134224
INPP4A	hsa-miR-4697-3p	81.4846	NM_001134224
INPP4A	hsa-miR-580-3p	81.2806	NM_001134225

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Motifs and transcription factors (TFs) regulating INPP4A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
INPP4A	metacluster_198.3	ZFP64 (directAnnotation).
INPP4A	cisbp__M00341	PAX6 (directAnnotation).
INPP4A	cisbp__M00968	MTF2 (directAnnotation).
INPP4A	transfac_pro__M00716	ZBTB14 (directAnnotation).
INPP4A	transfac_pro__M04893	TAF1 (directAnnotation).
INPP4A	transfac_pro__M04916	TAF1 (directAnnotation).
INPP4A	transfac_pro__M02089	E2F3 (directAnnotation).
INPP4A	transfac_pro__M04817	ZBTB33 (directAnnotation).
INPP4A	transfac_pro__M07310	SP5 (directAnnotation).
INPP4A	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
INPP4A	hdpi__NRL	NRL (directAnnotation).
INPP4A	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
INPP4A	hdpi__HIP2	UBE2K (directAnnotation).
INPP4A	transfac_pro__M07387	ZBTB7A (directAnnotation).
INPP4A	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
INPP4A	transfac_pro__M01783	SP2 (directAnnotation).
INPP4A	cisbp__M07938	E2F1 (directAnnotation).
INPP4A	metacluster_7.13	ZFX (directAnnotation).
INPP4A	tfdimers__MD00483	ZBTB14 (directAnnotation).
INPP4A	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
INPP4A	hdpi__GTF3C2	GTF3C2 (directAnnotation).
INPP4A	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
INPP4A	metacluster_115.1	NEUROD1; PHF1; ZBTB20; ZNF17; ZNF296; ZNF350; ZNF486; ZNF574; ZNF589; ZNF891 (directAnnotation). IRF4; IRF6; PRDM5 (inferredBy_Orthology).
INPP4A	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
INPP4A	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
INPP4A	transfac_pro__M03806	ZBTB7C (directAnnotation).
INPP4A	hdpi__ZNF304	ZNF304 (directAnnotation).
INPP4A	cisbp__M00788	ZFY (inferredBy_Orthology).
INPP4A	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
INPP4A	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
INPP4A	transfac_pro__M00800	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
INPP4A	cisbp__M00343	PAX6 (directAnnotation).
INPP4A	transfac_pro__M12697	ZNF142 (directAnnotation).
INPP4A	metacluster_197.3	E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F1; E2F2; E2F2; E2F2; E2F2; E2F2; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F3; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F4; E2F5; E2F5; E2F5; E2F5; E2F6; E2F7; E2F7; E2F7; RB1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP1; TFDP2; TFDP2 (directAnnotation).
INPP4A	transfac_pro__M00938	E2F1 (directAnnotation).
INPP4A	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
INPP4A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
INPP4A	transfac_pro__M12694	ZFP14 (directAnnotation).
INPP4A	transfac_pro__M01253	CNOT3 (directAnnotation).
INPP4A	transfac_pro__M04617	ZBTB7A (directAnnotation).
INPP4A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
INPP4A	metacluster_24.1	HIC1; HIC1; ZNF816; ZNF816; ZNF816; ZXDC (directAnnotation).
INPP4A	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."