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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IL24

Summary for IL24

Gene information	Gene symbol	IL24
	Ensembl ID	ENSG00000162892
	Entrez ID	11009
	Gene name	interleukin 24
	Synonyms	C49A\|FISP\|IL-24\|IL10B\|mda-7\|Mob-5\|ST16
	Gene type	protein_coding
	UniProtAcc	Q13007

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Dataset with differentially expressed gene: IL24

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	0.755423	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-1.00494	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.576536	0.00e+00

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Expression of IL24 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IL24

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
IL24	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating IL24

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IL24	hsa-miR-3121-3p	94.4198	NM_001185158
IL24	hsa-miR-5194	93.9857	NM_001185158
IL24	hsa-miR-6738-5p	92.9021	NM_001185156
IL24	hsa-miR-1914-3p	92.9021	NM_001185156
IL24	hsa-miR-939-3p	91.2577	NM_001185158
IL24	hsa-miR-203a-3p	89.9209	NM_001185158
IL24	hsa-miR-6756-5p	89.2427	NM_001185156
IL24	hsa-miR-6766-5p	89.2427	NM_001185156
IL24	hsa-miR-888-3p	89.018	NM_001185156
IL24	hsa-miR-4719	89	NM_001185156
IL24	hsa-miR-6809-5p	87	NM_001185156
IL24	hsa-miR-511-5p	85.6616	NM_001185158
IL24	hsa-miR-3135a	81.3763	NM_001185156
IL24	hsa-miR-3190-3p	80.4819	NM_001185156

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Motifs and transcription factors (TFs) regulating IL24

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IL24	transfac_pro__M06181	ZNF165 (directAnnotation).
IL24	metacluster_171.4	TEAD1; TEAD1; TEAD1; TEAD1; TEAD3; TEAD3; TEAD4; TEAD4; TEAD4; TEAD4 (directAnnotation). TEAD1; TEAD2; TEAD4; TEAD4 (inferredBy_Orthology).
IL24	metacluster_50.1	BATF; BATF; BATF; BATF; BNC2; FOS; FOSB; FOSL1; FOSL1; IRF4; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMAD2; SMAD3 (directAnnotation). BATF; BATF; BATF; FOS; FOSL1; FOSL2; JDP2; JUN; JUN; JUND (inferredBy_Orthology).
IL24	transfac_pro__M06854	ZNF600 (directAnnotation).
IL24	swissregulon__hs__ETV6	ETV6 (directAnnotation).
IL24	swissregulon__hs__ELF2	ELF2 (directAnnotation).
IL24	transfac_pro__M04748	GABPA (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."