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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: IL1R1

Summary for IL1R1

Gene information	Gene symbol	IL1R1
	Ensembl ID	ENSG00000115594
	Entrez ID	3554
	Gene name	interleukin 1 receptor type 1
	Synonyms	CD121A\|D2S1473\|IL1R\|IL1RA
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: IL1R1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.438727	7.08e-28
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.305	3.08e-16
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.306234	4.28e-29

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Expression of IL1R1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IL1R1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IL1R1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IL1R1	hsa-miR-548aw	98.5201	NM_000877
IL1R1	hsa-miR-4718	93.065	NM_000877
IL1R1	hsa-miR-498-5p	92.2028	NM_001320984
IL1R1	hsa-miR-518a-5p	91.9831	NM_000877
IL1R1	hsa-miR-527	91.9831	NM_000877
IL1R1	hsa-miR-3978	90.6845	NM_000877
IL1R1	hsa-miR-4999-5p	88.9828	NM_000877
IL1R1	hsa-miR-5695	88.3147	NM_000877
IL1R1	hsa-miR-4282	88.2618	NM_000877
IL1R1	hsa-miR-3688-3p	87.5781	NM_001320984
IL1R1	hsa-miR-1468-3p	87.4945	NM_001320984
IL1R1	hsa-miR-3163	87.3319	NM_001320984
IL1R1	hsa-miR-6744-5p	86.3001	NM_001320984
IL1R1	hsa-miR-3064-5p	85.6511	NM_001320984
IL1R1	hsa-miR-6504-5p	85.6511	NM_001320984
IL1R1	hsa-miR-3085-3p	85.6511	NM_001320984
IL1R1	hsa-miR-5590-5p	85.4771	NM_001320984
IL1R1	hsa-miR-1323	85.3747	NM_001320984
IL1R1	hsa-miR-4469	85.2434	NM_001320984
IL1R1	hsa-miR-1537-5p	85.102	NM_000877
IL1R1	hsa-miR-3148	84.6684	NM_001320984
IL1R1	hsa-miR-2276-3p	84.1287	NM_001320984
IL1R1	hsa-miR-4659b-3p	83.869	NM_001320984
IL1R1	hsa-miR-4659a-3p	83.869	NM_001320984
IL1R1	hsa-miR-4441	82.9686	NM_001320984
IL1R1	hsa-miR-4761-3p	82.766	NM_001320984
IL1R1	hsa-miR-101-3p	82.3115	NM_001320984
IL1R1	hsa-miR-548o-3p	81.9868	NM_001320984
IL1R1	hsa-miR-3190-5p	81.0901	NM_001320984
IL1R1	hsa-miR-6124	80.9269	NM_001320984

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Motifs and transcription factors (TFs) regulating IL1R1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IL1R1	metacluster_22.19	NFE2 (directAnnotation).
IL1R1	metacluster_22.18	BACH2 (inferredBy_Orthology).
IL1R1	metacluster_22.37	BACH1 (directAnnotation).
IL1R1	metacluster_22.36	BACH2 (directAnnotation).
IL1R1	metacluster_22.34	BACH2 (directAnnotation).
IL1R1	metacluster_22.20	MAFG (directAnnotation).
IL1R1	metacluster_22.35	MAFK (directAnnotation).
IL1R1	metacluster_22.16	BACH2 (directAnnotation).
IL1R1	kznf__ZNF384_Schmitges2016_RCADE	ZNF384 (directAnnotation).
IL1R1	metacluster_22.11	NFE2 (directAnnotation).
IL1R1	cisbp__M01815	CEBPE (inferredBy_Orthology).
IL1R1	metacluster_22.13	MAFK (inferredBy_Orthology).
IL1R1	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
IL1R1	metacluster_157.2	ATF3; ATF3; ATF3; BACH1; BACH1; BACH1; BACH2; BACH2; BACH2; BACH2; BATF; BATF; BCL11A; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JDP2; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; JUND; MAF; MAFB; MAFF; MAFG; MAFK; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2; NFE2L3; ZNF3; ZSCAN5C (directAnnotation). FOSL1; JUN; JUN; JUN; JUNB; JUNB; JUND (inferredBy_Orthology).
IL1R1	metacluster_22.33	MAFK (inferredBy_Orthology).
IL1R1	metacluster_22.32	NFE2L2 (directAnnotation).
IL1R1	metacluster_22.39	NFE2L2 (directAnnotation).
IL1R1	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
IL1R1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
IL1R1	tfdimers__MD00069	IKZF1; PDX1 (directAnnotation).
IL1R1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
IL1R1	metacluster_22.21	NFE2L2 (inferredBy_Orthology).
IL1R1	transfac_pro__M04916	TAF1 (directAnnotation).
IL1R1	metacluster_22.17	NFE2 (directAnnotation).
IL1R1	metacluster_30.4	BACH1; BACH1; MAFG; MAFG; NFE2; NFE2; NFE2L1; NFE2L1; NFE2L2 (directAnnotation).
IL1R1	metacluster_111.5	E4F1; E4F1 (directAnnotation).
IL1R1	metacluster_135.11	NR2C2 (directAnnotation).
IL1R1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
IL1R1	metacluster_7.13	ZFX (directAnnotation).
IL1R1	cisbp__M00968	MTF2 (directAnnotation).
IL1R1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
IL1R1	cisbp__M00341	PAX6 (directAnnotation).
IL1R1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
IL1R1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
IL1R1	metacluster_175.1	ZNF283 (directAnnotation).
IL1R1	hdpi__ZNF304	ZNF304 (directAnnotation).
IL1R1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
IL1R1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
IL1R1	transfac_pro__M01199	TRIM28 (directAnnotation).
IL1R1	metacluster_151.2	ZNF23 (directAnnotation).
IL1R1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
IL1R1	transfac_pro__M03806	ZBTB7C (directAnnotation).
IL1R1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
IL1R1	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
IL1R1	swissregulon__hs__MTA3	MTA3 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
IL1R1	"Anakinra"	DB00026	biotech
IL1R1	"Foreskin fibroblast (neonatal)"	DB10770	biotech
IL1R1	"OMS-103HP"	DB05303	small molecule
IL1R1	"SD118"	DB05207	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."