Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IL17RA

Summary for IL17RA

Gene information	Gene symbol	IL17RA
	Ensembl ID	ENSG00000177663
	Entrez ID	23765
	Gene name	interleukin 17 receptor A
	Synonyms	CD217\|CDw217\|hIL-17R\|IL-17RA\|IL17R
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: IL17RA

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	0.357928	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.289535	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	Mono/Macro	0.359382	0.00e+00
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	cDCs	0.251574	4.18e-03
GSE197268_Tisa-cel	patients	Peripheral blood mononuclear cells	Acute lymphoblastic leukemia	Large B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	tisa-cel (CAR-T)	pre	Mono/Macro	0.329345	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	-0.326427	3.72e-05

Top

Expression of IL17RA in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to IL17RA

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating IL17RA

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IL17RA	hsa-miR-8485	99.0191	NM_001289905
IL17RA	hsa-miR-661	93.0272	NM_001289905
IL17RA	hsa-miR-4755-3p	88.7677	NM_001289905
IL17RA	hsa-miR-3617-5p	86.5523	NM_001289905
IL17RA	hsa-miR-641	86.5523	NM_001289905
IL17RA	hsa-miR-6778-3p	84.6606	NM_001289905
IL17RA	hsa-miR-6134	84.4706	NM_001289905
IL17RA	hsa-miR-4707-3p	84.0407	NM_001289905
IL17RA	hsa-miR-3941	83.3936	NM_001289905
IL17RA	hsa-miR-4482-3p	82.7058	NM_001289905
IL17RA	hsa-miR-4266	80.444	NM_001289905
IL17RA	hsa-miR-6873-3p	80.3961	NM_001289905

Page: 1

Top

Motifs and transcription factors (TFs) regulating IL17RA

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IL17RA	transfac_pro__M06092	ZNF28 (directAnnotation).
IL17RA	taipale_tf_pairs__ERF_HOXA3_RSCGGAWNNNNNNNYMATTA_CAP_repr	ERF; HOXA3 (directAnnotation).
IL17RA	taipale_tf_pairs__ETV2_SPDEF_NSCGGACGGAWATCCGSNT_CAP	ETV2; SPDEF (directAnnotation).
IL17RA	tfdimers__MD00039	GATA1; GATA2; GATA3; GATA4; GATA5; GATA6 (directAnnotation).
IL17RA	transfac_pro__M04706	RELA (directAnnotation).
IL17RA	hdpi__FOSL1	FOSL1 (directAnnotation).
IL17RA	metacluster_156.4	NFIL3 (directAnnotation). NFIL3 (inferredBy_Orthology).
IL17RA	metacluster_156.3	DBP; DBP; DBP; DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; NFIL3; TEF; TEF; TEF; TEF; TEF (directAnnotation). DBP; DBP; DBP; DBP; DBP; HLF; HLF; HLF; HLF; HLF; NFIL3; NFIL3; NFILZ; NFILZ; TEF; TEF; TEF; TEF (inferredBy_Orthology).
IL17RA	tfdimers__MD00404	FOXA1; FOXA2; FOXA3; FOXP3 (directAnnotation).
IL17RA	tfdimers__MD00313	ING4; NFATC4 (directAnnotation).
IL17RA	transfac_pro__M07310	SP5 (directAnnotation).
IL17RA	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
IL17RA	transfac_pro__M02089	E2F3 (directAnnotation).
IL17RA	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
IL17RA	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
IL17RA	metacluster_7.13	ZFX (directAnnotation).
IL17RA	kznf__ZNF267_Imbeault2017_OM_RCADE	ZNF267 (directAnnotation).
IL17RA	cisbp__M00341	PAX6 (directAnnotation).
IL17RA	kznf__ZNF311_Imbeault2017_RP_ChIP-seq	ZNF311 (directAnnotation).
IL17RA	hdpi__GTF3C2	GTF3C2 (directAnnotation).
IL17RA	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
IL17RA	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
IL17RA	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
IL17RA	metacluster_160.20	JUND; PRDM15 (directAnnotation).
IL17RA	jaspar__MA0131.2	HINFP (directAnnotation).
IL17RA	transfac_pro__M06126	ZNF43 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."