Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IGFBP5

Summary for IGFBP5

Gene information	Gene symbol	IGFBP5
	Ensembl ID	ENSG00000115461
	Entrez ID	3488
	Gene name	insulin like growth factor binding protein 5
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P24593

Top

Dataset with differentially expressed gene: IGFBP5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-2.47179	2.15e-03
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	1.89599	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	3.02894	0.00e+00
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.637386	0.00e+00

Top

Expression of IGFBP5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to IGFBP5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating IGFBP5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IGFBP5	hsa-miR-608	98.5587	NM_000599
IGFBP5	hsa-miR-4651	98.5587	NM_000599
IGFBP5	hsa-miR-5006-3p	98.3441	NM_000599
IGFBP5	hsa-miR-3059-5p	98.2527	NM_000599
IGFBP5	hsa-miR-4755-5p	98.1083	NM_000599
IGFBP5	hsa-miR-5580-5p	97.8551	NM_000599
IGFBP5	hsa-miR-1252-3p	97.7525	NM_000599
IGFBP5	hsa-miR-670-3p	97.1484	NM_000599
IGFBP5	hsa-miR-143-3p	96.982	NM_000599
IGFBP5	hsa-miR-4770	96.982	NM_000599
IGFBP5	hsa-miR-6088	96.1763	NM_000599
IGFBP5	hsa-miR-7111-3p	96.1637	NM_000599
IGFBP5	hsa-miR-4492	94.1411	NM_000599
IGFBP5	hsa-miR-3652	93.9881	NM_000599
IGFBP5	hsa-miR-4430	93.9881	NM_000599
IGFBP5	hsa-miR-4723-3p	93.1489	NM_000599
IGFBP5	hsa-miR-570-3p	92.884	NM_000599
IGFBP5	hsa-miR-6769b-3p	92.413	NM_000599
IGFBP5	hsa-miR-3183	92.413	NM_000599
IGFBP5	hsa-miR-4708-5p	92.33	NM_000599
IGFBP5	hsa-miR-3613-3p	92.004	NM_000599
IGFBP5	hsa-miR-4803	91.6448	NM_000599
IGFBP5	hsa-miR-3064-5p	91.1719	NM_000599
IGFBP5	hsa-miR-6504-5p	91.1719	NM_000599
IGFBP5	hsa-miR-3085-3p	91.1719	NM_000599
IGFBP5	hsa-miR-5088-3p	90.7976	NM_000599
IGFBP5	hsa-miR-762	90.6685	NM_000599
IGFBP5	hsa-miR-5001-5p	90.6661	NM_000599
IGFBP5	hsa-miR-4498	90.5411	NM_000599
IGFBP5	hsa-miR-1238-3p	90.4586	NM_000599
IGFBP5	hsa-miR-5787	90.4473	NM_000599
IGFBP5	hsa-miR-6847-5p	90.118	NM_000599
IGFBP5	hsa-miR-4505	89.8475	NM_000599
IGFBP5	hsa-miR-6852-5p	89.6955	NM_000599
IGFBP5	hsa-miR-211-5p	88.7348	NM_000599
IGFBP5	hsa-miR-204-5p	88.7348	NM_000599
IGFBP5	hsa-miR-744-3p	88.6843	NM_000599
IGFBP5	hsa-miR-193a-3p	88.0478	NM_000599
IGFBP5	hsa-miR-193b-3p	88.0478	NM_000599
IGFBP5	hsa-miR-5700	87.8583	NM_000599
IGFBP5	hsa-miR-3150a-3p	86.9305	NM_000599
IGFBP5	hsa-miR-6763-5p	86.9305	NM_000599
IGFBP5	hsa-miR-4318	86.8239	NM_000599
IGFBP5	hsa-miR-6747-5p	85.8792	NM_000599
IGFBP5	hsa-miR-4460	84.7694	NM_000599
IGFBP5	hsa-miR-7106-5p	84.4374	NM_000599
IGFBP5	hsa-miR-140-5p	84.4357	NM_000599
IGFBP5	hsa-miR-3121-3p	84.2869	NM_000599
IGFBP5	hsa-miR-4797-5p	84.1144	NM_000599
IGFBP5	hsa-miR-586	83.6222	NM_000599

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating IGFBP5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IGFBP5	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
IGFBP5	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
IGFBP5	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
IGFBP5	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
IGFBP5	taipale_cyt_meth__ZBTB2_NTTTMCGGTWAN_eDBD	ZBTB2 (directAnnotation).
IGFBP5	metacluster_198.7	AHR; ZBTB14; ZBTB14; ZBTB14 (directAnnotation).
IGFBP5	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
IGFBP5	transfac_pro__M04950	EGR1 (directAnnotation).
IGFBP5	transfac_pro__M06032	ZNF727 (directAnnotation).
IGFBP5	transfac_pro__M06141	ZNF708 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."