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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IGF2BP2

Summary for IGF2BP2

Gene information	Gene symbol	IGF2BP2
	Ensembl ID	ENSG00000073792
	Entrez ID	10644
	Gene name	insulin like growth factor 2 mRNA binding protein 2
	Synonyms	IMP-2\|p62
	Gene type	protein_coding
	UniProtAcc	Q9Y6M1

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Dataset with differentially expressed gene: IGF2BP2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.311388	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.526003	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.437793	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	-0.273216	0.00e+00

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Expression of IGF2BP2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IGF2BP2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IGF2BP2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IGF2BP2	hsa-miR-3059-5p	97.8683	NM_001291874
IGF2BP2	hsa-miR-6516-5p	97.6974	NM_001291875
IGF2BP2	hsa-miR-153-5p	97.3247	NM_001291874
IGF2BP2	hsa-miR-877-3p	96.5894	NM_001291874
IGF2BP2	hsa-miR-576-5p	96.0613	NM_001291875
IGF2BP2	hsa-miR-6844	95.8228	NM_001291874
IGF2BP2	hsa-miR-4263	95.2155	NM_001291875
IGF2BP2	hsa-miR-6881-3p	95.0478	NM_001291874
IGF2BP2	hsa-miR-548aw	94.711	NM_001291875
IGF2BP2	hsa-miR-548d-3p	94.645	NM_001291875
IGF2BP2	hsa-miR-548z	94.645	NM_001291875
IGF2BP2	hsa-miR-548h-3p	94.645	NM_001291875
IGF2BP2	hsa-miR-548bb-3p	94.645	NM_001291875
IGF2BP2	hsa-miR-548ac	94.645	NM_001291875
IGF2BP2	hsa-miR-7162-3p	94.0725	NM_001291875
IGF2BP2	hsa-miR-4262	93.2413	NM_001291875
IGF2BP2	hsa-miR-5087	92.5251	NM_001291875
IGF2BP2	hsa-miR-1287-5p	92.1134	NM_001291875
IGF2BP2	hsa-miR-181d-5p	91.87	NM_001291875
IGF2BP2	hsa-miR-4493	90.8769	NM_001291875
IGF2BP2	hsa-miR-4500	90.7889	NM_001291875
IGF2BP2	hsa-miR-181b-5p	90.4457	NM_001291875
IGF2BP2	hsa-miR-181a-5p	90.4457	NM_001291875
IGF2BP2	hsa-miR-181c-5p	90.4457	NM_001291875
IGF2BP2	hsa-miR-7160-5p	90.1836	NM_001291875
IGF2BP2	hsa-miR-4753-3p	89.161	NM_001291874
IGF2BP2	hsa-miR-4311	89.1348	NM_001291875
IGF2BP2	hsa-miR-656-3p	89.0441	NM_001291875
IGF2BP2	hsa-miR-4653-3p	88.4647	NM_001291875
IGF2BP2	hsa-miR-3160-5p	88.0414	NM_001291874
IGF2BP2	hsa-miR-9-5p	87.108	NM_001291875
IGF2BP2	hsa-let-7b-5p	86.2631	NM_001291875
IGF2BP2	hsa-let-7g-5p	86.2631	NM_001291875
IGF2BP2	hsa-let-7a-5p	86.2631	NM_001291875
IGF2BP2	hsa-miR-98-5p	86.2631	NM_001291875
IGF2BP2	hsa-let-7e-5p	86.2631	NM_001291875
IGF2BP2	hsa-let-7i-5p	86.2631	NM_001291875
IGF2BP2	hsa-let-7c-5p	86.2631	NM_001291875
IGF2BP2	hsa-let-7f-5p	86.2631	NM_001291875
IGF2BP2	hsa-miR-10395-5p	86.1962	NM_001291875
IGF2BP2	hsa-miR-135b-5p	86.1772	NM_001291875
IGF2BP2	hsa-miR-135a-5p	86.1772	NM_001291875
IGF2BP2	hsa-miR-596	86.1188	NM_001291875
IGF2BP2	hsa-miR-670-3p	85.7512	NM_001291874
IGF2BP2	hsa-miR-125a-3p	85.621	NM_001291875
IGF2BP2	hsa-miR-5010-3p	85.1924	NM_001291874
IGF2BP2	hsa-miR-1193	85.0818	NM_001291875
IGF2BP2	hsa-miR-659-3p	85.0612	NM_001291875
IGF2BP2	hsa-miR-6848-3p	84.6667	NM_001291875
IGF2BP2	hsa-miR-6843-3p	84.6667	NM_001291875

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Motifs and transcription factors (TFs) regulating IGF2BP2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IGF2BP2	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
IGF2BP2	metacluster_151.2	ZNF23 (directAnnotation).
IGF2BP2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
IGF2BP2	transfac_pro__M04826	EP300 (directAnnotation).
IGF2BP2	transfac_pro__M01122	ZNF219 (directAnnotation).
IGF2BP2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
IGF2BP2	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
IGF2BP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
IGF2BP2	swissregulon__hs__GLIS2	GLIS2 (directAnnotation).
IGF2BP2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
IGF2BP2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
IGF2BP2	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
IGF2BP2	metacluster_84.2	RARA (directAnnotation).
IGF2BP2	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
IGF2BP2	transfac_pro__M01253	CNOT3 (directAnnotation).
IGF2BP2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
IGF2BP2	jaspar__MA1122.1	TFDP1 (directAnnotation).
IGF2BP2	cisbp__M00341	PAX6 (directAnnotation).
IGF2BP2	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
IGF2BP2	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
IGF2BP2	tfdimers__MD00391	KLF4 (directAnnotation).
IGF2BP2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
IGF2BP2	transfac_pro__M01973	PLAG1 (directAnnotation).
IGF2BP2	transfac_pro__M12697	ZNF142 (directAnnotation).
IGF2BP2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
IGF2BP2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
IGF2BP2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
IGF2BP2	taipale_tf_pairs__FOXO1_ELK1_RSCGGATGTTRTN_CAP	ELK1; FOXO1 (directAnnotation).
IGF2BP2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
IGF2BP2	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
IGF2BP2	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
IGF2BP2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
IGF2BP2	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
IGF2BP2	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
IGF2BP2	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
IGF2BP2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
IGF2BP2	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
IGF2BP2	transfac_pro__M04748	GABPA (directAnnotation).
IGF2BP2	kznf__ZNF441_Imbeault2017_OM_RCADE	ZNF441 (directAnnotation).
IGF2BP2	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
IGF2BP2	transfac_pro__M04862	NRF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."