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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IGF2

Summary for IGF2

Gene information	Gene symbol	IGF2
	Ensembl ID	ENSG00000167244
	Entrez ID	3481
	Gene name	insulin like growth factor 2
	Synonyms	C11orf43\|FLJ44734\|IGF-II
	Gene type	protein_coding
	UniProtAcc	P01344

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Dataset with differentially expressed gene: IGF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	4.61567	8.60e-21
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	1.12456	0.00e+00

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Expression of IGF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IGF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IGF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IGF2	hsa-miR-6867-5p	100	NM_001291861
IGF2	hsa-miR-4447	98.9829	NM_000612
IGF2	hsa-miR-6751-5p	98.8646	NM_000612
IGF2	hsa-miR-6803-5p	98.284	NM_000612
IGF2	hsa-miR-7109-5p	97.7854	NM_000612
IGF2	hsa-miR-6846-5p	97.2161	NM_000612
IGF2	hsa-miR-4534	97.0488	NM_000612
IGF2	hsa-miR-5572	96.7102	NM_000612
IGF2	hsa-miR-4472	96.4773	NM_000612
IGF2	hsa-miR-7110-5p	96.2879	NM_000612
IGF2	hsa-miR-6842-5p	96.2879	NM_000612
IGF2	hsa-miR-6756-5p	96.2324	NM_001291861
IGF2	hsa-miR-6766-5p	96.2324	NM_001291861
IGF2	hsa-miR-450a-2-3p	95.8583	NM_000612
IGF2	hsa-miR-10395-5p	95.3058	NM_000612
IGF2	hsa-miR-6848-5p	95.0119	NM_000612
IGF2	hsa-miR-6752-5p	94.2337	NM_000612
IGF2	hsa-miR-8082	93.991	NM_000612
IGF2	hsa-miR-491-5p	93.2285	NM_001291861
IGF2	hsa-miR-210-3p	92.5396	NM_001291861
IGF2	hsa-miR-1275	92.5029	NM_000612
IGF2	hsa-miR-6887-3p	92.1685	NM_000612
IGF2	hsa-miR-4260	90.7282	NM_000612
IGF2	hsa-miR-1972	90.6703	NM_001291861
IGF2	hsa-miR-4662a-5p	90.1668	NM_000612
IGF2	hsa-miR-6825-5p	90.006	NM_001291861
IGF2	hsa-miR-4303	89.9031	NM_001291861
IGF2	hsa-miR-4664-5p	89.7859	NM_000612
IGF2	hsa-miR-5010-3p	89.2259	NM_001291861
IGF2	hsa-miR-10226	88.5076	NM_001291861
IGF2	hsa-miR-3134	87.6558	NM_000612
IGF2	hsa-miR-6857-5p	87.2676	NM_001291861
IGF2	hsa-miR-342-5p	87.0442	NM_000612
IGF2	hsa-miR-6721-5p	86.8077	NM_000612
IGF2	hsa-miR-4665-5p	86.6147	NM_000612
IGF2	hsa-miR-6796-5p	85.4379	NM_001291861
IGF2	hsa-miR-23b-5p	85.1808	NM_000612
IGF2	hsa-miR-660-3p	85.0338	NM_000612
IGF2	hsa-miR-6742-5p	84.9861	NM_000612
IGF2	hsa-miR-4666b	84.475	NM_001291861
IGF2	hsa-miR-6762-3p	83.8896	NM_000612
IGF2	hsa-miR-192-3p	83.8762	NM_000612
IGF2	hsa-miR-328-5p	82.6569	NM_000612
IGF2	hsa-miR-23a-5p	82.386	NM_000612
IGF2	hsa-miR-4697-5p	81.3687	NM_000612
IGF2	hsa-miR-4488	81.3687	NM_000612
IGF2	hsa-miR-1237-5p	81.3687	NM_000612
IGF2	hsa-miR-6835-5p	81.2137	NM_000612
IGF2	hsa-miR-6885-5p	80.6706	NM_000612
IGF2	hsa-miR-147a	80.3084	NM_001291861

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Motifs and transcription factors (TFs) regulating IGF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IGF2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
IGF2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
IGF2	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
IGF2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
IGF2	transfac_pro__M02281	SP1 (directAnnotation).
IGF2	metacluster_135.8	ZNF516; ZNF536 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."