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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: IFIT2

Summary for IFIT2

Gene information	Gene symbol	IFIT2
	Ensembl ID	ENSG00000119922
	Entrez ID	3433
	Gene name	interferon induced protein with tetratricopeptide repeats 2
	Synonyms	cig42\|G10P2\|GARG-39\|IFI-54\|IFI54\|ISG-54\|ISG-54K
	Gene type	protein_coding
	UniProtAcc	P09913

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Dataset with differentially expressed gene: IFIT2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	Mono/Macro	-0.255821	0.00e+00

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Expression of IFIT2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to IFIT2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating IFIT2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
IFIT2	hsa-miR-3976	92.1194	NM_001547
IFIT2	hsa-miR-647	90.1816	NM_001547
IFIT2	hsa-miR-409-3p	89.9354	NM_001547
IFIT2	hsa-miR-4766-5p	89.5715	NM_001547
IFIT2	hsa-miR-154-5p	89.1923	NM_001547
IFIT2	hsa-miR-6762-3p	89.0936	NM_001547
IFIT2	hsa-miR-125a-3p	88.9631	NM_001547
IFIT2	hsa-miR-6880-5p	86.8943	NM_001547
IFIT2	hsa-miR-195-3p	86.5675	NM_001547
IFIT2	hsa-miR-16-2-3p	86.5675	NM_001547
IFIT2	hsa-miR-6083	85.7562	NM_001547
IFIT2	hsa-miR-7703	85.442	NM_001547
IFIT2	hsa-miR-4307	83.8611	NM_001547
IFIT2	hsa-miR-6873-3p	82.525	NM_001547
IFIT2	hsa-miR-6801-5p	81.9147	NM_001547
IFIT2	hsa-miR-10393-3p	81.9147	NM_001547
IFIT2	hsa-miR-371a-5p	80.2095	NM_001547

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Motifs and transcription factors (TFs) regulating IFIT2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
IFIT2	tfdimers__MD00007	E2F1; IRF8 (directAnnotation).
IFIT2	metacluster_2.9	IRF2; IRF2; IRF2; PRDM1; PRDM1 (directAnnotation). PRDM1 (inferredBy_Orthology).
IFIT2	metacluster_167.7	IRF8 (inferredBy_Orthology).
IFIT2	swissregulon__hs__ETV6	ETV6 (directAnnotation).
IFIT2	metacluster_168.17	ZNF417; ZNF587 (directAnnotation).
IFIT2	jaspar__MA1532.2	NR1D2 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."